iPTMnet Report for O15379 (HDAC3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O15379 / HDAC3_HUMAN
Protein Name Histone deacetylase 3
Gene Name Name: HDAC3
Organism Homo sapiens (Human)

PRO ID PR:O15379
DAG View
PRO Name histone deacetylase 3 (human)
Definition A histone deacetylase 3 that is encoded in the genome of human.
Short Label hHDAC3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O15379 (HDAC3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K3 Ubiquitination PhosphoSitePlus
K25 Ubiquitination PhosphoSitePlus
K44 Ubiquitination PhosphoSitePlus
Y66 Phosphorylation PhosphoSitePlus
S74 Phosphorylation PhosphoSitePlus
K121 Ubiquitination PhosphoSitePlus
C123 Methylation IEDB 31844290
C145 Methylation IEDB 31844290
C251 Methylation IEDB 31844290
C306 Methylation IEDB 31844290
Y325 Phosphorylation PhosphoSitePlus
Y328 Phosphorylation PhosphoSitePlus   RLIMS-P 31430896
Y331 Phosphorylation PhosphoSitePlus   RLIMS-P 31430896
S374 Phosphorylation IEDB   PhosphoSitePlus 35494241
Y404 Phosphorylation PhosphoSitePlus
Y414 Phosphorylation PhosphoSitePlus
S424 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P+   RLIMS-P   Signor   UniProt 23186163, 17081983, 15805470, ...19690332, 26663086, 25305081, 26356530, 29555935, 32398667, 31430896, 27874833, 27798112
S424 Phosphorylation P68400 (CSNK2A1) PhosphoSitePlus   Signor 26663086, 15805470
S424 Phosphorylation Q5S007 (LRRK2) RLIMS-P+ 27798112
S424 Phosphorylation Q9BXM7 (PINK1) RLIMS-P+ 25305081
Site PTM Type PTM Enzyme Score Source PMID
Y404 Phosphorylation HPRD 17081983
S405 Phosphorylation HPRD 17081983
S424 Phosphorylation HPRD   PRO 15805470, 27798112, 18452278
S424 Phosphorylation P68400 (CSNK2A1) HPRD 15805470, 18452278


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000049891 (hHDAC3/iso:1/Phos:1) pS424 PRO 27798112


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation O15379 (HDAC3) S424 P00558 (PGK1) increased_association eFIP 26356530


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:O60566 (hBUB1B) Interaction PR:O15379 (hHDAC3) PRO
PR:P29590-5 (hPML/iso:5) Interaction PR:O15379 (hHDAC3) PRO 11259576


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K3 N3 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K44 N44 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S74 N74 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
C251 R251 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S424 N424 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]