Protein Information

Cytoscape View

UniProt AC / UniProt ID O15379 / HDAC3_HUMAN
Protein Name Histone deacetylase 3
Gene Name Name: HDAC3
Organism Homo sapiens (Human)

PRO ID PR:O15379
DAG View
PRO Name histone deacetylase 3 (human)
Definition A histone deacetylase 3 that is encoded in the genome of human.
Short Label hHDAC3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

O15379 (HDAC3) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
K3 Ubiquitination PhosphoSitePlus
K25 Ubiquitination PhosphoSitePlus
K44 Ubiquitination PhosphoSitePlus
Y66 Phosphorylation PhosphoSitePlus
S74 Phosphorylation PhosphoSitePlus
K121 Ubiquitination PhosphoSitePlus
Y325 Phosphorylation PhosphoSitePlus
Y328 Phosphorylation PhosphoSitePlus   RLIMS-P 31430896
Y331 Phosphorylation PhosphoSitePlus   RLIMS-P 31430896
S374 Phosphorylation PhosphoSitePlus
Y404 Phosphorylation PhosphoSitePlus
Y414 Phosphorylation PhosphoSitePlus
S424 Phosphorylation Q9BXM7 (PINK1) , Q5S007 (LRRK2) , P68400 (CSNK2A1) phospho.ELM   PhosphoSitePlus   RLIMS-P+   RLIMS-P   Signor   UniProt 23186163, 17081983, 15805470, ...19690332, 26663086, 25305081, 26356530, 29555935, 32398667, 31430896, 27874833, 27798112
Site PTM Type PTM Enzyme Score Source PMID
Y404 Phosphorylation HPRD 17081983
S405 Phosphorylation HPRD 17081983
S424 Phosphorylation P68400 (CSNK2A1) HPRD   PRO 15805470, 27798112, 18452278


PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000049891 (hHDAC3/iso:1/Phos:1) pS424 PRO 27798112

PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation O15379 (HDAC3) S424 P00558 (PGK1) increased_association eFIP 26356530

Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:O60566 (hBUB1B) Interaction PR:O15379 (hHDAC3) PRO
PR:P29590-5 (hPML/iso:5) Interaction PR:O15379 (hHDAC3) PRO 11259576

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K3 N3 Biomuta DOID:1324 / lung cancer [ tcga ]
K44 N44 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
S74 N74 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
S424 N424 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc, tcga ]