iPTMnet Report for O15379 (HDAC3)
Protein Information
| UniProt AC / UniProt ID | O15379 / HDAC3_HUMAN |
| Protein Name | Histone deacetylase 3 |
| Gene Name | Name: HDAC3 |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:O15379 |
| PRO Name | histone deacetylase 3 (human) |
| Definition | A histone deacetylase 3 that is encoded in the genome of human. |
| Short Label | hHDAC3 |
| Category | organism-gene |
DAG ViewO15379 (HDAC3) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| K3 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K25 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K44 | Ubiquitination | score1 | PhosphoSitePlus | |||
| Y66 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S74 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K121 | Ubiquitination | score1 | PhosphoSitePlus | |||
| C123 | Methylation | score1 | IEDB | 31844290 | ||
| C145 | Methylation | score1 | IEDB | 31844290 | ||
| C251 | Methylation | score1 | IEDB | 31844290 | ||
| C306 | Methylation | score1 | IEDB | 31844290 | ||
| Y325 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y328 | Phosphorylation | score3 | PhosphoSitePlus RLIMS-P | 31430896 | ||
| Y331 | Phosphorylation | score3 | PhosphoSitePlus RLIMS-P | 31430896 | ||
| S374 | Phosphorylation | score2 | IEDB PhosphoSitePlus | 35494241 | ||
| Y404 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y414 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S424 | Phosphorylation | P68400 (CSNK2A1) , Q5S007 (LRRK2) , Q9BXM7 (PINK1) | score4 | phospho.ELM PhosphoSitePlus RLIMS-P+ RLIMS-P Signor UniProt | 23186163, 17081983, 15805470, ... |
Proteoforms
| PRO ID (Short Label) | Sites | PTM Enzyme | Source | PMID | |
|---|---|---|---|---|---|
| PR:000049891 (hHDAC3/iso:1/Phos:1) | pS424 | PRO | 27798112 |
PTM-dependent PPI
|
PTM type | Substrate | Site | Interactant | Association type | Source | PMID |
|---|---|---|---|---|---|---|---|
| Phosphorylation | O15379 (HDAC3) | S424 | P00558 (PGK1) | increased_association | eFIP | 26356530 |
Proteoform PPIs
|
Protein 1 | Relation | Protein 2 | Source | PMID |
|---|---|---|---|---|---|
| PR:O60566 (hBUB1B) | Interaction | PR:O15379 (hHDAC3) | PRO | ||
| PR:P29590-5 (hPML/iso:5) | Interaction | PR:O15379 (hHDAC3) | PRO | 11259576 |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| K3 | N3 | Biomuta | DOID:1324 / lung cancer [ cosmic, icgc ] | |
| K44 | N44 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] | |
| S74 | N74 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] | |
| C251 | R251 | Biomuta | DOID:9256 / colorectal cancer [ cosmic, icgc ] | |
| S424 | N424 | Biomuta | DOID:4362 / cervical cancer [ cosmic, icgc ] |
