iPTMnet Report for O15350 (TP73)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O15350 / P73_HUMAN
Protein Name Tumor protein p73
Gene Name Name: TP73
Synonyms:P73;
Organism Homo sapiens (Human)

PRO ID PR:O15350
DAG View
PRO Name tumor protein p73 (human)
Definition A tumor protein p73 that is encoded in the genome of human.
Short Label hTP73
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O15350 (TP73) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T14 Phosphorylation RLIMS-P 19218448
T27 Phosphorylation P53350 (PLK1) neXtProt   PhosphoSitePlus   RLIMS-P   Signor   UniProt 18418051, 18174154
Y28 Phosphorylation P08631 (HCK) neXtProt   PhosphoSitePlus   RLIMS-P   UniProt 17535448
S47 Phosphorylation O14757 (CHEK1) phospho.ELM   PhosphoSitePlus   Signor 14585975
S48 Phosphorylation Q9NYY3 (PLK2) PhosphoSitePlus 26640387, 26625870
T86 Phosphorylation P06493 (CDK1) , P24941 (CDK2) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 22002055, 15985436, 12676926
Y99 Phosphorylation P00519 (ABL1) , A0A173G4P4 (Abl fusion) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 33375680, 10391251, 10391250, ...17535448, 28257089, 27228340
C159 Methylation IEDB 31844290
S166 Phosphorylation PhosphoSitePlus
T167 Phosphorylation PhosphoSitePlus
T173 Phosphorylation PhosphoSitePlus
S235 Phosphorylation O14965 (AURKA) PhosphoSitePlus   RLIMS-P 22340593
S289 Phosphorylation Q05655 (PRKCD) neXtProt   Signor 12097319
K321 Acetylation PhosphoSitePlus
K327 Acetylation PhosphoSitePlus
K331 Acetylation PhosphoSitePlus
S333 Phosphorylation PhosphoSitePlus
K345 Ubiquitination PhosphoSitePlus
S388 Phosphorylation P05771-2 (PRKCB) , P17252 (PRKCA) PhosphoSitePlus 19158275
S426 Phosphorylation Q13131 (PRKAA1) PhosphoSitePlus   RLIMS-P 24874608
S471 Phosphorylation PhosphoSitePlus
T568 Phosphorylation PhosphoSitePlus
K627 Sumoylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T86 Phosphorylation P06493 (CDK1) , P24941 (CDK2) HPRD 12676926
Y99 Phosphorylation P00519 (ABL1) HPRD 10391251
Site PTM Type PTM Enzyme Score Source PMID
Y99 Phosphorylation PhosphoSitePlus
S289 Phosphorylation Q05655 (PRKCD) PhosphoSitePlus 12097319
Site PTM Type PTM Enzyme Score Source PMID
T13 Phosphorylation PhosphoSitePlus


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q9NZC7 (WWOX) Y33 O15350 (TP73) increased_association eFIP 24137446


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:000037507 (hYAP1/iso:3/UnPhos:1) Interaction PR:O15350 (hTP73) PRO 21214929, 21562856
PR:000037508 (hYAP1/iso:3/Phos:1) increased Interaction PR:O15350 (hTP73) PRO 21214929, 21562856
PR:000037510 (hYAP1/Phos:1) decreased Interaction PR:O15350 (hTP73) PRO 21945154
PR:O43684 (hBUB3) Interaction PR:O15350-5 (hTP73/iso:5) PRO 20057499
PR:O43684 (hBUB3) Interaction PR:O15350-2 (hTP73/iso:2) PRO 20057499
PR:O43684 (hBUB3) Interaction PR:O15350-1 (hTP73/iso:1) PRO 20057499
PR:O43684 (hBUB3) Interaction PR:O15350-3 (hTP73/iso:3) PRO 20057499
PR:O60566 (hBUB1B) Interaction PR:O15350 (hTP73) PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T13 M13 Biomuta DOID:10283 / prostate cancer [ cosmic ]
S48 I48 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ] DOID:3571 / liver cancer [ cosmic ]
S166 F166 Biomuta DOID:4159 / skin cancer [ cosmic ]
S235 R235 Biomuta DOID:10534 / stomach cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ]
S289 F289 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S333 R333 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S471 R471 Biomuta DOID:10534 / stomach cancer [ cosmic ]