iPTMnet Report for O15350 (TP73)
Protein Information
| UniProt AC / UniProt ID | O15350 / P73_HUMAN |
| Protein Name | Tumor protein p73 |
| Gene Name | Name: TP73 Synonyms:P73; |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:O15350 |
| PRO Name | tumor protein p73 (human) |
| Definition | A tumor protein p73 that is encoded in the genome of human. |
| Short Label | hTP73 |
| Category | organism-gene |
DAG ViewO15350 (TP73) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| T14 | Phosphorylation | score0 | RLIMS-P | 19218448 | ||
| T27 | Phosphorylation | score4 | neXtProt PhosphoSitePlus RLIMS-P Signor UniProt | 18418051, 18174154 | ||
| T27 | Phosphorylation | P53350 (PLK1) | score4 | neXtProt PhosphoSitePlus Signor | 18418051, 18174154 | |
| Y28 | Phosphorylation | score3 | neXtProt PhosphoSitePlus RLIMS-P UniProt | 17535448 | ||
| Y28 | Phosphorylation | P08631 (HCK) | score2 | neXtProt | 17535448 | |
| S47 | Phosphorylation | score3 | phospho.ELM PhosphoSitePlus Signor | 14585975 | ||
| S47 | Phosphorylation | O14757 (CHEK1) | score3 | PhosphoSitePlus Signor | 14585975 | |
| S48 | Phosphorylation | score3 | PhosphoSitePlus | 26640387, 26625870 | ||
| S48 | Phosphorylation | Q9NYY3 (PLK2) | score3 | PhosphoSitePlus | 26640387, 26625870 | |
| T86 | Phosphorylation | score4 | neXtProt phospho.ELM PhosphoSitePlus RLIMS-P Signor | 22002055, 15985436, 12676926 | ||
| T86 | Phosphorylation | P06493 (CDK1) | score4 | PhosphoSitePlus Signor | 22002055, 12676926 | |
| T86 | Phosphorylation | P24941 (CDK2) | score4 | phospho.ELM PhosphoSitePlus Signor | 22002055, 12676926 | |
| Y99 | Phosphorylation | score4 | neXtProt phospho.ELM PhosphoSitePlus RLIMS-P Signor UniProt | 33375680, 10391251, 10391250, ... | ||
| Y99 | Phosphorylation | A0A173G4P4 (Abl fusion) | score2 | phospho.ELM | 10391251 | |
| Y99 | Phosphorylation | P00519 (ABL1) | score4 | neXtProt PhosphoSitePlus Signor | 10391251, 10391250 | |
| C159 | Methylation | score1 | IEDB | 31844290 | ||
| S166 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T167 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T173 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S235 | Phosphorylation | score3 | PhosphoSitePlus RLIMS-P | 22340593 | ||
| S235 | Phosphorylation | O14965 (AURKA) | score2 | PhosphoSitePlus | 22340593 | |
| S289 | Phosphorylation | score3 | neXtProt Signor | 12097319 | ||
| S289 | Phosphorylation | Q05655 (PRKCD) | score3 | neXtProt Signor | 12097319 | |
| K321 | Acetylation | score1 | PhosphoSitePlus | |||
| K327 | Acetylation | score1 | PhosphoSitePlus | |||
| K331 | Acetylation | score1 | PhosphoSitePlus | |||
| S333 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K345 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S388 | Phosphorylation | score2 | PhosphoSitePlus | 19158275 | ||
| S388 | Phosphorylation | P05771-2 (PRKCB) | score2 | PhosphoSitePlus | 19158275 | |
| S388 | Phosphorylation | P17252 (PRKCA) | score2 | PhosphoSitePlus | 19158275 | |
| S426 | Phosphorylation | score3 | PhosphoSitePlus RLIMS-P | 24874608 | ||
| S426 | Phosphorylation | Q13131 (PRKAA1) | score2 | PhosphoSitePlus | 24874608 | |
| S471 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T568 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K627 | Sumoylation | score1 | PhosphoSitePlus |
|
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| T86 | Phosphorylation | score1 | HPRD | 12676926 | ||
| T86 | Phosphorylation | P06493 (CDK1) | score1 | HPRD | 12676926 | |
| T86 | Phosphorylation | P24941 (CDK2) | score1 | HPRD | 12676926 | |
| Y99 | Phosphorylation | score1 | HPRD | 10391251 | ||
| Y99 | Phosphorylation | P00519 (ABL1) | score1 | HPRD | 10391251 |
|
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| Y99 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S289 | Phosphorylation | score2 | PhosphoSitePlus | 12097319 | ||
| S289 | Phosphorylation | Q05655 (PRKCD) | score2 | PhosphoSitePlus | 12097319 |
|
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| T13 | Phosphorylation | score1 | PhosphoSitePlus |
PTM-dependent PPI
|
PTM type | Substrate | Site | Interactant | Association type | Source | PMID |
|---|---|---|---|---|---|---|---|
| Phosphorylation | Q9NZC7 (WWOX) | Y33 | O15350 (TP73) | increased_association | eFIP | 24137446 |
Proteoform PPIs
|
Protein 1 | Relation | Protein 2 | Source | PMID |
|---|---|---|---|---|---|
| PR:000037507 (hYAP1/iso:3/UnPhos:1) | Interaction | PR:O15350 (hTP73) | PRO | 21214929, 21562856 | |
| PR:000037508 (hYAP1/iso:3/Phos:1) | increased Interaction | PR:O15350 (hTP73) | PRO | 21214929, 21562856 | |
| PR:000037510 (hYAP1/Phos:1) | decreased Interaction | PR:O15350 (hTP73) | PRO | 21945154 | |
| PR:O43684 (hBUB3) | Interaction | PR:O15350-5 (hTP73/iso:5) | PRO | 20057499 | |
| PR:O43684 (hBUB3) | Interaction | PR:O15350-2 (hTP73/iso:2) | PRO | 20057499 | |
| PR:O43684 (hBUB3) | Interaction | PR:O15350-1 (hTP73/iso:1) | PRO | 20057499 | |
| PR:O43684 (hBUB3) | Interaction | PR:O15350-3 (hTP73/iso:3) | PRO | 20057499 | |
| PR:O60566 (hBUB1B) | Interaction | PR:O15350 (hTP73) | PRO |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| T13 | M13 | Biomuta | DOID:10283 / prostate cancer [ cosmic ] | |
| S48 | I48 | Biomuta | DOID:4159 / skin cancer [ cosmic, icgc ] DOID:3571 / liver cancer [ cosmic ] | |
| S166 | F166 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
| S235 | R235 | Biomuta | DOID:10534 / stomach cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ] | |
| S289 | F289 | Biomuta | DOID:4159 / skin cancer [ cosmic, icgc ] | |
| S333 | R333 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
| S471 | R471 | Biomuta | DOID:10534 / stomach cancer [ cosmic ] |
