iPTMnet Report for O15259 (NPHP1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O15259 / NPHP1_HUMAN
Protein Name Nephrocystin-1
Gene Name Name: NPHP1
Synonyms:NPH1;
Organism Homo sapiens (Human)

PRO ID PR:O15259
DAG View
PRO Name nephrocystin-1 (human)
Definition A nephrocystin-1 that is encoded in the genome of human.
Short Label hNPHP1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O15259 (NPHP1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y46 Phosphorylation Q14289 (PTK2B) neXtProt   PhosphoSitePlus   RLIMS-P   UniProt 21357692
K60 Ubiquitination PhosphoSitePlus
K68 Ubiquitination PhosphoSitePlus
T87 Phosphorylation P53350 (PLK1) neXtProt   RLIMS-P 22701722
T102 Phosphorylation PhosphoSitePlus
S104 Phosphorylation PhosphoSitePlus
S121 Phosphorylation P68400 (CSNK2A1) PhosphoSitePlus   Signor   UniProt 16308564
S123 Phosphorylation P68400 (CSNK2A1) PhosphoSitePlus   Signor   UniProt 16308564
S126 Phosphorylation P68400 (CSNK2A1) PhosphoSitePlus   Signor   UniProt 16308564
K193 Acetylation PhosphoSitePlus
K196 Acetylation PhosphoSitePlus
Y349 Phosphorylation Q14289 (PTK2B) neXtProt   PhosphoSitePlus   RLIMS-P   UniProt 21357692
S376 Phosphorylation PhosphoSitePlus
S379 Phosphorylation PhosphoSitePlus
S382 Phosphorylation IEDB 35494241
S460 Phosphorylation PhosphoSitePlus
S474 Phosphorylation PhosphoSitePlus
K520 Ubiquitination PhosphoSitePlus
T542 Phosphorylation PhosphoSitePlus
S601 Phosphorylation PhosphoSitePlus
K633 Ubiquitination PhosphoSitePlus
Y721 Phosphorylation P12931 (SRC) , Q14289 (PTK2B) neXtProt   PhosphoSitePlus   RLIMS-P   UniProt 21357692


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T87 A87 Biomuta DOID:363 / uterine cancer [ icgc ]
Y349 H349 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S379 I379 Biomuta DOID:10283 / prostate cancer [ icgc ]
S382 L382 Biomuta DOID:4159 / skin cancer [ cosmic ]
S460 F460 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S474 Y474 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S601 N601 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
K633 N633 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
Y721 D721 Biomuta DOID:1324 / lung cancer [ cosmic ]