iPTMnet Report for O15259 (NPHP1)
Protein Information
| UniProt AC / UniProt ID | O15259 / NPHP1_HUMAN |
| Protein Name | Nephrocystin-1 |
| Gene Name | Name: NPHP1 Synonyms:NPH1; |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:O15259 |
| PRO Name | nephrocystin-1 (human) |
| Definition | A nephrocystin-1 that is encoded in the genome of human. |
| Short Label | hNPHP1 |
| Category | organism-gene |
DAG ViewO15259 (NPHP1) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| Y46 | Phosphorylation | score3 | neXtProt PhosphoSitePlus RLIMS-P UniProt | 21357692 | ||
| Y46 | Phosphorylation | Q14289 (PTK2B) | score3 | neXtProt PhosphoSitePlus | 21357692 | |
| K60 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K68 | Ubiquitination | score1 | PhosphoSitePlus | |||
| T87 | Phosphorylation | score3 | neXtProt RLIMS-P | 22701722 | ||
| T87 | Phosphorylation | P53350 (PLK1) | score2 | neXtProt | 22701722 | |
| T102 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S104 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S121 | Phosphorylation | score3 | PhosphoSitePlus Signor UniProt | 16308564 | ||
| S121 | Phosphorylation | P68400 (CSNK2A1) | score3 | PhosphoSitePlus Signor | 16308564 | |
| S123 | Phosphorylation | score3 | PhosphoSitePlus Signor UniProt | 16308564 | ||
| S123 | Phosphorylation | P68400 (CSNK2A1) | score3 | PhosphoSitePlus Signor | 16308564 | |
| S126 | Phosphorylation | score3 | PhosphoSitePlus Signor UniProt | 16308564 | ||
| S126 | Phosphorylation | P68400 (CSNK2A1) | score3 | PhosphoSitePlus Signor | 16308564 | |
| K193 | Acetylation | score1 | PhosphoSitePlus | |||
| K196 | Acetylation | score1 | PhosphoSitePlus | |||
| Y349 | Phosphorylation | score3 | neXtProt PhosphoSitePlus RLIMS-P UniProt | 21357692 | ||
| Y349 | Phosphorylation | Q14289 (PTK2B) | score3 | neXtProt PhosphoSitePlus | 21357692 | |
| S376 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S379 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S382 | Phosphorylation | score1 | IEDB | 35494241 | ||
| S460 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S474 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K520 | Ubiquitination | score1 | PhosphoSitePlus | |||
| T542 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S601 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K633 | Ubiquitination | score1 | PhosphoSitePlus | |||
| Y721 | Phosphorylation | score3 | neXtProt PhosphoSitePlus RLIMS-P UniProt | 21357692 | ||
| Y721 | Phosphorylation | P12931 (SRC) | score2 | PhosphoSitePlus | 21357692 | |
| Y721 | Phosphorylation | Q14289 (PTK2B) | score2 | neXtProt | 21357692 |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| T87 | A87 | Biomuta | DOID:363 / uterine cancer [ icgc ] | |
| Y349 | H349 | Biomuta | DOID:9256 / colorectal cancer [ cosmic, icgc ] | |
| S379 | I379 | Biomuta | DOID:10283 / prostate cancer [ icgc ] | |
| S382 | L382 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
| S460 | F460 | Biomuta | DOID:1612 / breast cancer [ cosmic, icgc ] | |
| S474 | Y474 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
| S601 | N601 | Biomuta | DOID:4606 / bile duct cancer [ cosmic ] | |
| K633 | N633 | Biomuta | DOID:5041 / esophageal cancer [ cosmic ] | |
| Y721 | D721 | Biomuta | DOID:1324 / lung cancer [ cosmic ] |
