iPTMnet Report O14791 APOL1

Protein Information

Cytoscape View

UniProt AC / UniProt ID	O14791 / APOL1_HUMAN
Protein Name	Apolipoprotein L1 precursor
Gene Name	Name: APOL1 Synonyms:APOL;
Organism	Homo sapiens (Human)

PRO ID	PR:O14791 DAG View
PRO Name	apolipoprotein L1 (human)
Definition	An apolipoprotein L1 that is encoded in the genome of human.
Short Label	hAPOL1
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

O14791 (APOL1) as Substrate

Expanded View

	Site	PTM Type	PTM Enzyme	Score	Source	PMID
	T59	O-Glycosylation		score1	GlyGen	30459171
	K148	Ubiquitination		score1	PhosphoSitePlus
	T236	O-Glycosylation		score2	GlyGen PhosphoSitePlus	23584533, 25813380
	N261	N-Glycosylation		score2	GlyGen UniProt	16335952
	T307	Phosphorylation		score1	PhosphoSitePlus
	S311	Phosphorylation		score2	PhosphoSitePlus UniProt	26091039, 24275569
	S314	Phosphorylation		score2	PhosphoSitePlus UniProt	26091039, 24275569

	Site	PTM Type	PTM Enzyme	Score	Source	PMID
	S311	Phosphorylation		score0	HPRD	19824718, 18702456, 20166139
	S314	Phosphorylation		score0	HPRD	19824718, 20166139

PTM sites affected in variants

Site	Variant	Source	PMID	Disease [Sample source]
K148	E148	Biomuta		DOID:1319 / brain cancer [ cosmic, icgc ]
T307	P307	Biomuta		DOID:4159 / skin cancer [ cosmic ]
S311	A311	Biomuta		DOID:263 / kidney cancer [ cosmic ]