iPTMnet Report for O14746 (TERT)
Protein Information
| UniProt AC / UniProt ID | O14746 / TERT_HUMAN |
| Protein Name | Telomerase reverse transcriptase |
| Gene Name | Name: TERT Synonyms:EST2,TCS1,TRT; |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:O14746 |
| PRO Name | telomerase reverse transcriptase (human) |
| Definition | A telomerase reverse transcriptase that is encoded in the genome of human. |
| Short Label | hTERT |
| Category | organism-gene |
DAG ViewO14746 (TERT) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| T26 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y122 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S134 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S227 | Phosphorylation | score4 | neXtProt phospho.ELM PhosphoSitePlus RLIMS-P Signor UniProt | 10224060, 22366458, 25999477, ... | ||
| S227 | Phosphorylation | P31749 (AKT1) | score3 | neXtProt PhosphoSitePlus Signor | 10224060 | |
| T249 | Phosphorylation | score3 | PhosphoSitePlus RLIMS-P | 32214089 | ||
| S349 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S457 | Phosphorylation | score2 | UniProt | 23362280 | ||
| C517 | Methylation | score1 | IEDB | 31844290 | ||
| S679 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T692 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y707 | Phosphorylation | score4 | phospho.ELM PhosphoSitePlus RLIMS-P Signor UniProt | 12808100, 18829466, 26034007, ... | ||
| Y707 | Phosphorylation | P12931 (SRC) | score4 | phospho.ELM PhosphoSitePlus Signor | 12808100, 20211239 | |
| T767 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S797 | Phosphorylation | score1 | phospho.ELM | 16565220 | ||
| S824 | Phosphorylation | score4 | neXtProt phospho.ELM PhosphoSitePlus RLIMS-P Signor | 10224060, 23486104, 22902867 | ||
| S824 | Phosphorylation | P31749 (AKT1) | score3 | neXtProt PhosphoSitePlus Signor | 10224060 | |
| S948 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y949 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K1059 | Acetylation | score1 | PhosphoSitePlus | |||
| T1113 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus | 16094384 | ||
| S1125 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus | 16094384 |
|
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| S227 | Phosphorylation | score1 | HPRD | 10224060 | ||
| S227 | Phosphorylation | P31749 (AKT1) | score1 | HPRD | 10224060 | |
| Y707 | Phosphorylation | score1 | HPRD | 12808100 | ||
| Y707 | Phosphorylation | P12931 (SRC) | score1 | HPRD | 12808100 |
|
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| S797 | Phosphorylation | score1 | PhosphoSitePlus |
|
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| K78 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K94 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K236 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K329 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K338 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S921 | Phosphorylation | score1 | PhosphoSitePlus |
Proteoform PPIs
|
Protein 1 | Relation | Protein 2 | Source | PMID |
|---|---|---|---|---|---|
| PR:000028994 (hAKT1/iso:1/Phos:1) | Interaction | PR:O14746-1 (hTERT/iso:1) | PRO | 12586360 |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| K236 | T236 | Biomuta | DOID:3571 / liver cancer [ cosmic, icgc ] | |
| S349 | C349 | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
| S679 | F679 | Biomuta | [ cosmic ] DOID:4159 / skin cancer [ cosmic ] | |
| S679 | A679 | Biomuta | DOID:1781 / thyroid gland cancer [ cosmic ] | |
| T692 | A692 | Biomuta | DOID:10534 / stomach cancer [ cosmic ] | |
| T767 | I767 | Biomuta | DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ] | |
| S824 | F824 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] |
