Protein Information

Cytoscape View


UniProt AC / UniProt ID O14746 / TERT_HUMAN
Protein Name Telomerase reverse transcriptase
Gene Name Name: TERT
Synonyms:EST2,TCS1,TRT;
Organism Homo sapiens (Human)

PRO ID PR:O14746
DAG View
PRO Name telomerase reverse transcriptase (human)
Definition A telomerase reverse transcriptase that is encoded in the genome of human.
Short Label hTERT
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O14746 (TERT) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T26 Phosphorylation PhosphoSitePlus
Y122 Phosphorylation PhosphoSitePlus
S134 Phosphorylation PhosphoSitePlus
S227 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 10224060, 22366458, 25999477, ...23486104
S227 Phosphorylation P31749 (AKT1) neXtProt   PhosphoSitePlus   Signor 10224060
T249 Phosphorylation PhosphoSitePlus   RLIMS-P 32214089
S349 Phosphorylation PhosphoSitePlus
S457 Phosphorylation UniProt 23362280
C517 Methylation IEDB 31844290
S679 Phosphorylation PhosphoSitePlus
T692 Phosphorylation PhosphoSitePlus
Y707 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 12808100, 18829466, 26034007, ...24413564, 20211239
Y707 Phosphorylation P12931 (SRC) phospho.ELM   PhosphoSitePlus   Signor 12808100, 20211239
T767 Phosphorylation PhosphoSitePlus
S797 Phosphorylation phospho.ELM 16565220
S824 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 10224060, 23486104, 22902867
S824 Phosphorylation P31749 (AKT1) neXtProt   PhosphoSitePlus   Signor 10224060
S948 Phosphorylation PhosphoSitePlus
Y949 Phosphorylation PhosphoSitePlus
K1059 Acetylation PhosphoSitePlus
T1113 Phosphorylation phospho.ELM   PhosphoSitePlus 16094384
S1125 Phosphorylation phospho.ELM   PhosphoSitePlus 16094384
Site PTM Type PTM Enzyme Score Source PMID
S227 Phosphorylation HPRD 10224060
S227 Phosphorylation P31749 (AKT1) HPRD 10224060
Y707 Phosphorylation HPRD 12808100
Y707 Phosphorylation P12931 (SRC) HPRD 12808100
Site PTM Type PTM Enzyme Score Source PMID
S797 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
K78 Ubiquitination PhosphoSitePlus
K94 Ubiquitination PhosphoSitePlus
K236 Ubiquitination PhosphoSitePlus
K329 Ubiquitination PhosphoSitePlus
K338 Ubiquitination PhosphoSitePlus
S921 Phosphorylation PhosphoSitePlus


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:000028994 (hAKT1/iso:1/Phos:1) Interaction PR:O14746-1 (hTERT/iso:1) PRO 12586360


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K236 T236 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
S349 C349 Biomuta DOID:1324 / lung cancer [ cosmic ]
S679 F679 Biomuta [ cosmic ] DOID:4159 / skin cancer [ cosmic ]
S679 A679 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ]
T692 A692 Biomuta DOID:10534 / stomach cancer [ cosmic ]
T767 I767 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S824 F824 Biomuta DOID:9256 / colorectal cancer [ cosmic ]