Protein Information

Cytoscape View

UniProt AC / UniProt ID O14746 / TERT_HUMAN
Protein Name Telomerase reverse transcriptase
Gene Name Name: TERT
Organism Homo sapiens (Human)

PRO ID PR:O14746
DAG View
PRO Name telomerase reverse transcriptase (human)
Definition A telomerase reverse transcriptase that is encoded in the genome of human.
Short Label hTERT
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

O14746 (TERT) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
T26 Phosphorylation PhosphoSitePlus
Y122 Phosphorylation PhosphoSitePlus
S134 Phosphorylation PhosphoSitePlus
S227 Phosphorylation P31749 (AKT1) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 10224060, 22366458, 25999477, ...23486104
S349 Phosphorylation PhosphoSitePlus
S457 Phosphorylation UniProt 23362280
S679 Phosphorylation PhosphoSitePlus
T692 Phosphorylation PhosphoSitePlus
Y707 Phosphorylation P12931 (SRC) phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 12808100, 18829466, 26034007, ...24413564, 20211239
T767 Phosphorylation PhosphoSitePlus
S797 Phosphorylation phospho.ELM 16565220
S824 Phosphorylation P31749 (AKT1) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 10224060, 23486104, 22902867
S948 Phosphorylation PhosphoSitePlus
Y949 Phosphorylation PhosphoSitePlus
K1059 Acetylation PhosphoSitePlus
T1113 Phosphorylation phospho.ELM   PhosphoSitePlus 16094384
S1125 Phosphorylation phospho.ELM   PhosphoSitePlus 16094384
Site PTM Type PTM Enzyme Score Source PMID
S227 Phosphorylation P31749 (AKT1) HPRD 10224060
Y707 Phosphorylation P12931 (SRC) HPRD 12808100
Site PTM Type PTM Enzyme Score Source PMID
S797 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
K78 Ubiquitination PhosphoSitePlus
K94 Ubiquitination PhosphoSitePlus
K236 Ubiquitination PhosphoSitePlus
K329 Ubiquitination PhosphoSitePlus
K338 Ubiquitination PhosphoSitePlus
S921 Phosphorylation PhosphoSitePlus

Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:000028994 (hAKT1/iso:1/Phos:1) Interaction PR:O14746-1 (hTERT/iso:1) PRO 12586360

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T767 I767 Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]
S824 A824 Biomuta DOID:1612 / breast cancer [ tcga ]