iPTMnet Report O14746 TERT

Protein Information

Cytoscape View

UniProt AC / UniProt ID	O14746 / TERT_HUMAN
Protein Name	Telomerase reverse transcriptase
Gene Name	Name: TERT Synonyms:EST2,TCS1,TRT;
Organism	Homo sapiens (Human)

PRO ID	PR:O14746 DAG View
PRO Name	telomerase reverse transcriptase (human)
Definition	A telomerase reverse transcriptase that is encoded in the genome of human.
Short Label	hTERT
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

O14746 (TERT) as Substrate

Expanded View

	Site	PTM Type	PTM Enzyme	Score	Source	PMID
	T26	Phosphorylation		score1	PhosphoSitePlus
	Y122	Phosphorylation		score1	PhosphoSitePlus
	S134	Phosphorylation		score1	PhosphoSitePlus
	S227	Phosphorylation	P31749 (AKT1)	score4	neXtProt phospho.ELM PhosphoSitePlus RLIMS-P Signor UniProt	10224060, 22366458, 25999477
	S349	Phosphorylation		score1	PhosphoSitePlus
	S457	Phosphorylation		score2	UniProt	23362280
	S679	Phosphorylation		score1	PhosphoSitePlus
	T692	Phosphorylation		score1	PhosphoSitePlus
	Y707	Phosphorylation	P12931 (SRC)	score4	phospho.ELM PhosphoSitePlus RLIMS-P Signor UniProt	12808100, 18829466, 26034007, ...24413564, 20211239
	T767	Phosphorylation		score1	PhosphoSitePlus
	S797	Phosphorylation		score1	phospho.ELM	16565220
	S824	Phosphorylation	P31749 (AKT1)	score4	neXtProt phospho.ELM PhosphoSitePlus RLIMS-P Signor	10224060, 22902867
	S948	Phosphorylation		score1	PhosphoSitePlus
	Y949	Phosphorylation		score1	PhosphoSitePlus
	K1059	Acetylation		score1	PhosphoSitePlus
	T1113	Phosphorylation		score2	phospho.ELM PhosphoSitePlus	16094384
	S1125	Phosphorylation		score2	phospho.ELM PhosphoSitePlus	16094384

	Site	PTM Type	PTM Enzyme	Score	Source	PMID
	S227	Phosphorylation	P31749 (AKT1)	score1	HPRD	10224060
	Y707	Phosphorylation	P12931 (SRC)	score1	HPRD	12808100

	Site	PTM Type	PTM Enzyme	Score	Source	PMID
	S797	Phosphorylation		score1	PhosphoSitePlus

	Site	PTM Type	PTM Enzyme	Score	Source	PMID
	K78	Ubiquitination		score1	PhosphoSitePlus
	K94	Ubiquitination		score1	PhosphoSitePlus
	K236	Ubiquitination		score1	PhosphoSitePlus
	K329	Ubiquitination		score1	PhosphoSitePlus
	K338	Ubiquitination		score1	PhosphoSitePlus
	S921	Phosphorylation		score1	PhosphoSitePlus

Proteoform PPIs

	Protein 1	Relation	Protein 2	Source	PMID
	PR:000028994 (hAKT1/iso:1/Phos:1)	Interaction	PR:O14746-1 (hTERT/iso:1)	PRO	12586360

PTM sites affected in variants

Site	Variant	Source	PMID	Disease [Sample source]
T767	I767	Biomuta		DOID:3963 / thyroid carcinoma [ cosmic, icgc ]
S824	A824	Biomuta		DOID:1612 / breast cancer [ tcga ]