iPTMnet Report for O14746 (TERT)
Protein Information
UniProt AC / UniProt ID | O14746 / TERT_HUMAN |
Protein Name | Telomerase reverse transcriptase |
Gene Name | Name: TERT Synonyms:EST2,TCS1,TRT; |
Organism | Homo sapiens (Human) |
PRO ID | PR:O14746 |
PRO Name | telomerase reverse transcriptase (human) |
Definition | A telomerase reverse transcriptase that is encoded in the genome of human. |
Short Label | hTERT |
Category | organism-gene |
O14746 (TERT) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
T26 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y122 | Phosphorylation | score1 | PhosphoSitePlus | |||
S134 | Phosphorylation | score1 | PhosphoSitePlus | |||
S227 | Phosphorylation | P31749 (AKT1) | score4 | neXtProt phospho.ELM PhosphoSitePlus RLIMS-P Signor UniProt | 10224060, 22366458, 25999477, ... | |
T249 | Phosphorylation | score3 | PhosphoSitePlus RLIMS-P | 32214089 | ||
S349 | Phosphorylation | score1 | PhosphoSitePlus | |||
S457 | Phosphorylation | score2 | UniProt | 23362280 | ||
C517 | Methylation | score1 | IEDB | 31844290 | ||
S679 | Phosphorylation | score1 | PhosphoSitePlus | |||
T692 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y707 | Phosphorylation | P12931 (SRC) | score4 | phospho.ELM PhosphoSitePlus RLIMS-P Signor UniProt | 12808100, 18829466, 26034007, ... | |
T767 | Phosphorylation | score1 | PhosphoSitePlus | |||
S797 | Phosphorylation | score1 | phospho.ELM | 16565220 | ||
S824 | Phosphorylation | P31749 (AKT1) | score4 | neXtProt phospho.ELM PhosphoSitePlus RLIMS-P Signor | 10224060, 23486104, 22902867 | |
S948 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y949 | Phosphorylation | score1 | PhosphoSitePlus | |||
K1059 | Acetylation | score1 | PhosphoSitePlus | |||
T1113 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus | 16094384 | ||
S1125 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus | 16094384 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
S227 | Phosphorylation | P31749 (AKT1) | score1 | HPRD | 10224060 | |
Y707 | Phosphorylation | P12931 (SRC) | score1 | HPRD | 12808100 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
S797 | Phosphorylation | score1 | PhosphoSitePlus |
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
K78 | Ubiquitination | score1 | PhosphoSitePlus | |||
K94 | Ubiquitination | score1 | PhosphoSitePlus | |||
K236 | Ubiquitination | score1 | PhosphoSitePlus | |||
K329 | Ubiquitination | score1 | PhosphoSitePlus | |||
K338 | Ubiquitination | score1 | PhosphoSitePlus | |||
S921 | Phosphorylation | score1 | PhosphoSitePlus |
Proteoform PPIs
Protein 1 | Relation | Protein 2 | Source | PMID | |
---|---|---|---|---|---|
PR:000028994 (hAKT1/iso:1/Phos:1) | Interaction | PR:O14746-1 (hTERT/iso:1) | PRO | 12586360 |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
K236 | T236 | Biomuta | DOID:3571 / liver cancer [ cosmic, icgc ] | |
S349 | C349 | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
S679 | F679 | Biomuta | [ cosmic ] DOID:4159 / skin cancer [ cosmic ] | |
S679 | A679 | Biomuta | DOID:1781 / thyroid gland cancer [ cosmic ] | |
T692 | A692 | Biomuta | DOID:10534 / stomach cancer [ cosmic ] | |
T767 | I767 | Biomuta | DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ] | |
S824 | F824 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] |