iPTMnet Report for O14744 (PRMT5)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O14744 / ANM5_HUMAN
Protein Name Protein arginine N-methyltransferase 5
Gene Name Name: PRMT5
Synonyms:HRMT1L5,IBP72,JBP1,SKB1;
Organism Homo sapiens (Human)

PRO ID PR:O14744
DAG View
PRO Name protein arginine N-methyltransferase 5 (human)
Definition A protein arginine N-methyltransferase 5 that is encoded in the genome of human.
Short Label hPRMT5
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O14744 (PRMT5) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 19413330, 22814378, 22223895
S12 Phosphorylation PhosphoSitePlus
S15 Phosphorylation PhosphoSitePlus   RLIMS-P 32456215, 28074910
S16 Phosphorylation RLIMS-P 28074910
C22 S-Nitrosylation dbSNO 19483679
C42 Methylation IEDB 31844290
K60 Ubiquitination PhosphoSitePlus
T67 Phosphorylation RLIMS-P 28074910
S69 O-Glycosylation GlyGen 34105348
S69 Phosphorylation RLIMS-P 28074910
S74 O-Glycosylation GlyGen 34105348
S74 Phosphorylation PhosphoSitePlus
T80 Phosphorylation PhosphoSitePlus   RLIMS-P 28074910
K85 Ubiquitination PhosphoSitePlus
K95 Ubiquitination PhosphoSitePlus
S103 Phosphorylation PhosphoSitePlus
T132 Phosphorylation PhosphoSitePlus
T139 Phosphorylation PhosphoSitePlus
T144 Phosphorylation PhosphoSitePlus
K200 Acetylation PhosphoSitePlus
K200 Ubiquitination PhosphoSitePlus
K227 Ubiquitination PhosphoSitePlus
K240 Ubiquitination PhosphoSitePlus
K241 Ubiquitination PhosphoSitePlus
Y280 Phosphorylation PhosphoSitePlus
Y283 Phosphorylation PhosphoSitePlus
Y286 Phosphorylation PhosphoSitePlus
Y297 Phosphorylation PRO   PhosphoSitePlus   Signor 21316606
Y297 Phosphorylation O60674 (JAK2) PhosphoSitePlus   Signor 21316606
Y304 Phosphorylation PRO   PhosphoSitePlus 21316606
Y304 Phosphorylation O60674 (JAK2) PhosphoSitePlus 21316606
Y307 Phosphorylation PRO   PhosphoSitePlus 21316606
Y307 Phosphorylation O60674 (JAK2) PhosphoSitePlus 21316606
S310 Phosphorylation PhosphoSitePlus
Y324 Phosphorylation PhosphoSitePlus   RLIMS-P 32759981
K329 Ubiquitination PhosphoSitePlus
K333 Ubiquitination PhosphoSitePlus
S335 Phosphorylation PhosphoSitePlus
Y342 Phosphorylation PhosphoSitePlus
K343 Ubiquitination PhosphoSitePlus
R348 Methylation PhosphoSitePlus
K387 Ubiquitination PhosphoSitePlus
T400 Phosphorylation IEDB 35494241
S446 Phosphorylation RLIMS-P 32759981
K479 Ubiquitination PhosphoSitePlus
K490 Ubiquitination PhosphoSitePlus
C599 Methylation IEDB 31844290
T634 Phosphorylation RLIMS-P 32759981
Site PTM Type PTM Enzyme Score Source PMID
S12 Phosphorylation HPRD 19651622
Site PTM Type PTM Enzyme Score Source PMID
R2 Methylation PhosphoSitePlus


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000048929 (hPRMT5/Phos:1) pY297,pY304,pY307 PRO


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation O14744 (PRMT5) S15 P19838 (NFKB1) unknown eFIP 32456215
Phosphorylation O14744 (PRMT5) S15 Q04206 (RELA) unknown eFIP 32456215
Phosphorylation Q9NRZ9 (HELLS) S503 O14744 (PRMT5) unknown eFIP 32994405