Protein Information

Cytoscape View

UniProt AC / UniProt ID O14744 / ANM5_HUMAN
Protein Name Protein arginine N-methyltransferase 5
Gene Name Name: PRMT5
Organism Homo sapiens (Human)

PRO ID PR:O14744
DAG View
PRO Name protein arginine N-methyltransferase 5 (human)
Definition A protein arginine N-methyltransferase 5 that is encoded in the genome of human.
Short Label hPRMT5
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

O14744 (PRMT5) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 19413330, 22814378, 22223895
S12 Phosphorylation PhosphoSitePlus
S15 Phosphorylation RLIMS-P 28074910
S16 Phosphorylation RLIMS-P 28074910
C22 S-Nitrosylation dbSNO 19483679
K60 Ubiquitination PhosphoSitePlus
T67 Phosphorylation RLIMS-P 28074910
S69 Phosphorylation RLIMS-P 28074910
S74 Phosphorylation PhosphoSitePlus
T80 Phosphorylation PhosphoSitePlus   RLIMS-P 28074910
K85 Ubiquitination PhosphoSitePlus
K95 Ubiquitination PhosphoSitePlus
T132 Phosphorylation PhosphoSitePlus
T139 Phosphorylation PhosphoSitePlus
T144 Phosphorylation PhosphoSitePlus
K200 Acetylation PhosphoSitePlus
K200 Ubiquitination PhosphoSitePlus
K227 Ubiquitination PhosphoSitePlus
K240 Ubiquitination PhosphoSitePlus
K241 Ubiquitination PhosphoSitePlus
Y280 Phosphorylation PhosphoSitePlus
Y283 Phosphorylation PhosphoSitePlus
Y286 Phosphorylation PhosphoSitePlus
Y297 Phosphorylation O60674 (JAK2) PRO   PhosphoSitePlus   Signor 21316606
Y304 Phosphorylation O60674 (JAK2) PRO   PhosphoSitePlus 21316606
Y307 Phosphorylation O60674 (JAK2) PRO   PhosphoSitePlus 21316606
S310 Phosphorylation PhosphoSitePlus
K329 Ubiquitination PhosphoSitePlus
K333 Ubiquitination PhosphoSitePlus
Y342 Phosphorylation PhosphoSitePlus
K343 Ubiquitination PhosphoSitePlus
R348 Methylation PhosphoSitePlus
K387 Ubiquitination PhosphoSitePlus
K479 Ubiquitination PhosphoSitePlus
K490 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S12 Phosphorylation HPRD 19651622
Site PTM Type PTM Enzyme Score Source PMID
R2 Methylation PhosphoSitePlus


PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000048929 (hPRMT5/Phos:1) pY297,pY304,pY307 PRO

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
A2 S2 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
T80 M80 Biomuta DOID:363 / uterine cancer [ tcga ] DOID:1909 / melanoma [ cosmic ]
T132 N132 Biomuta DOID:3070 / malignant glioma [ tcga ]
Y283 * Biomuta DOID:3571 / liver cancer [ icgc ]
Y286 H286 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ] DOID:1909 / melanoma [ cosmic ]
Y286 * Biomuta DOID:1324 / lung cancer [ cosmic ]
R348 * Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]