iPTMnet Report for O14672 (ADAM10)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O14672 / ADA10_HUMAN
Protein Name Disintegrin and metalloproteinase domain-containing protein 10 precursor
Gene Name Name: ADAM10
Synonyms:KUZ,MADM;
Organism Homo sapiens (Human)

PRO ID PR:O14672
DAG View
PRO Name disintegrin and metalloproteinase domain-containing protein 10 (human)
Definition A disintegrin and metalloproteinase domain-containing protein 10 that is encoded in the genome of human.
Short Label hADAM10
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O14672 (ADAM10) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S36 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
Y37 O-Glycosylation GlyGen 23584533
K45 Ubiquitination PhosphoSitePlus
T130 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
K166 Ubiquitination PhosphoSitePlus
K184 Ubiquitination PhosphoSitePlus
T194 O-Glycosylation GlyGen 30459171, 25813380
T214 Phosphorylation PhosphoSitePlus
Y257 Phosphorylation PhosphoSitePlus
N267 N-Glycosylation GlyGen 18381078
S269 O-Glycosylation GlyGen 35289036
N278 N-Glycosylation GlyGen   UniProt 19159218, 24190977, 23090970, ...18381078, 19349973, 16263699, 29741879, 29224781
K284 Ubiquitination PhosphoSitePlus
S357 Phosphorylation PhosphoSitePlus
T397 O-Glycosylation GlyGen 25813380
K410 Ubiquitination PhosphoSitePlus
S436 Phosphorylation PhosphoSitePlus
N439 N-Glycosylation GlyGen 23090970, 29741879, 18381078, ...24190977
S441 O-Glycosylation GlyGen 35289036
N551 N-Glycosylation GlyGen 23090970, 18381078, 24190977
N556 N-Glycosylation GlyGen 24190977
K601 Ubiquitination PhosphoSitePlus
S605 Phosphorylation PhosphoSitePlus
K659 Acetylation IEDB 34357683
S705 Phosphorylation PhosphoSitePlus
K709 Sumoylation PhosphoSitePlus
K709 Ubiquitination PhosphoSitePlus
K714 Ubiquitination PhosphoSitePlus
T719 Phosphorylation PhosphoSitePlus   UniProt 26091039, 23186163, 24275569
K721 Ubiquitination PhosphoSitePlus
S740 Phosphorylation PhosphoSitePlus
Y741 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S269 T269 Biomuta DOID:363 / uterine cancer [ icgc ]
N278 S278 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
N278 K278 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S705 N705 Biomuta DOID:263 / kidney cancer [ cosmic ]
K714 N714 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y741 H741 Biomuta DOID:363 / uterine cancer [ icgc ]