Protein Information

Cytoscape View

UniProt AC / UniProt ID O14672 / ADA10_HUMAN
Protein Name Disintegrin and metalloproteinase domain-containing protein 10 precursor
Gene Name Name: ADAM10
Organism Homo sapiens (Human)

PRO ID PR:O14672
DAG View
PRO Name disintegrin and metalloproteinase domain-containing protein 10 (human)
Definition A disintegrin and metalloproteinase domain-containing protein 10 that is encoded in the genome of human.
Short Label hADAM10
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

O14672 (ADAM10) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
S36 O-Glycosylation PhosphoSitePlus
K45 Ubiquitination PhosphoSitePlus
T130 O-Glycosylation PhosphoSitePlus
K166 Ubiquitination PhosphoSitePlus
K184 Ubiquitination PhosphoSitePlus
T214 Phosphorylation PhosphoSitePlus
Y257 Phosphorylation PhosphoSitePlus
N278 N-Glycosylation UniProt 16263699, 29224781, 19159218, ...19349973
K284 Ubiquitination PhosphoSitePlus
S357 Phosphorylation PhosphoSitePlus
K410 Ubiquitination PhosphoSitePlus
S436 Phosphorylation PhosphoSitePlus
K601 Ubiquitination PhosphoSitePlus
S605 Phosphorylation PhosphoSitePlus
S705 Phosphorylation PhosphoSitePlus
K709 Sumoylation PhosphoSitePlus
K709 Ubiquitination PhosphoSitePlus
K714 Ubiquitination PhosphoSitePlus
T719 Phosphorylation PhosphoSitePlus   UniProt 26091039, 23186163, 24275569
K721 Ubiquitination PhosphoSitePlus
S740 Phosphorylation PhosphoSitePlus
Y741 Phosphorylation PhosphoSitePlus

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T214 K214 Biomuta DOID:3571 / liver cancer [ icgc ]
N278 S278 Biomuta DOID:11934 / head and neck cancer [ tcga ]
K714 N714 Biomuta DOID:1909 / melanoma [ cosmic ]
Y741 H741 Biomuta DOID:363 / uterine cancer [ tcga ]