iPTMnet Report for O00763 (ACACB)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O00763 / ACACB_HUMAN
Protein Name Acetyl-CoA carboxylase 2 precursor
Gene Name Name: ACACB
Synonyms:ACC2,ACCB;
Organism Homo sapiens (Human)

PRO ID PR:O00763
DAG View
PRO Name acetyl-CoA carboxylase 2 (human)
Definition An acetyl-CoA carboxylase 2 that is encoded in the genome of human.
Short Label hACACB
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O00763 (ACACB) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S35 Phosphorylation PhosphoSitePlus   UniProt 24275569
T70 Phosphorylation PhosphoSitePlus   UniProt 24275569
S72 Phosphorylation PhosphoSitePlus
S91 Phosphorylation PhosphoSitePlus   UniProt 24275569
S95 Phosphorylation PhosphoSitePlus   UniProt 24275569
S169 Phosphorylation PhosphoSitePlus
S192 Phosphorylation PhosphoSitePlus
S195 Phosphorylation PhosphoSitePlus
S200 Phosphorylation PhosphoSitePlus   UniProt 24275569
T216 Phosphorylation PhosphoSitePlus
S220 Phosphorylation PhosphoSitePlus
S222 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 14613924, 12488245, 19900410, ...9148944, 24740690, 17276402, 18614941
S222 Phosphorylation P54646 (PRKAA2) Signor 14613924, 9148944
S222 Phosphorylation Q13131 (PRKAA1) PhosphoSitePlus 17276402
S246 Phosphorylation PhosphoSitePlus
K262 Ubiquitination PhosphoSitePlus
K274 Ubiquitination PhosphoSitePlus
K454 Acetylation PhosphoSitePlus
S469 Phosphorylation PhosphoSitePlus   UniProt 24275569
K663 Ubiquitination PhosphoSitePlus
C703 Methylation IEDB 31844290
K722 Ubiquitination PhosphoSitePlus
S808 Phosphorylation PhosphoSitePlus
S865 Phosphorylation PhosphoSitePlus
Y866 Phosphorylation PhosphoSitePlus
T895 Phosphorylation PhosphoSitePlus
C1077 Methylation IEDB 31844290
S1340 Phosphorylation PhosphoSitePlus
T1342 Phosphorylation PhosphoSitePlus   UniProt 24275569
S1350 Phosphorylation PhosphoSitePlus
T1351 Phosphorylation PhosphoSitePlus
K1413 Ubiquitination PhosphoSitePlus
S1414 Phosphorylation PhosphoSitePlus
K1450 Acetylation PhosphoSitePlus
Y1456 Phosphorylation PhosphoSitePlus
K1473 Ubiquitination PhosphoSitePlus
Y1489 Phosphorylation PhosphoSitePlus
S1557 Phosphorylation PhosphoSitePlus
Y1560 Phosphorylation PhosphoSitePlus
T1641 Phosphorylation PhosphoSitePlus
Y1658 Phosphorylation PhosphoSitePlus
Y1664 Phosphorylation PhosphoSitePlus
Y1826 Phosphorylation PhosphoSitePlus
S1831 Phosphorylation PhosphoSitePlus
Y2327 Phosphorylation IEDB 35494241
S2347 Phosphorylation PhosphoSitePlus
T2458 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S37 Phosphorylation HPRD 18669648
S222 Phosphorylation HPRD 20166139, 12413941, 14613924, ...9148944, 14532170
S222 Phosphorylation P54646 (PRKAA2) HPRD 20166139, 12413941, 14613924, ...9148944, 14532170
T1342 Phosphorylation HPRD 20166139


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S91 F91 Biomuta DOID:4159 / skin cancer [ cosmic ]
S95 F95 Biomuta DOID:4159 / skin cancer [ cosmic ]
S200 F200 Biomuta DOID:4159 / skin cancer [ cosmic ]
S200 C200 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S469 I469 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K663 E663 Biomuta DOID:1319 / brain cancer [ cosmic ]
S865 N865 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S1350 I1350 Biomuta DOID:363 / uterine cancer [ icgc ]
S1350 R1350 Biomuta DOID:263 / kidney cancer [ cosmic ]
S1557 F1557 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1831 N1831 Biomuta DOID:263 / kidney cancer [ cosmic ]
T2458 I2458 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]