Protein Information

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UniProt AC / UniProt ID O00418 / EF2K_HUMAN
Protein Name Eukaryotic elongation factor 2 kinase
Gene Name Name: EEF2K
Organism Homo sapiens (Human)

PRO ID PR:O00418
DAG View
PRO Name eukaryotic elongation factor 2 kinase (human)
Definition An elongation factor 2 kinase that is encoded in the genome of human.
Short Label hEEF2K
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O00418 (EEF2K) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 22223895
S18 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 21406692, 23186163, ...16964243, 18767875, 19664994, 19664995, 15144186, 19651622, 17322306, 18669648, 19690332, 20068231, 17081983
S27 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19413330, 17081983, 24275569
S31 Phosphorylation HPRD   PhosphoSitePlus 19413330, 17081983
Y37 Phosphorylation PhosphoSitePlus
Y59 Phosphorylation PhosphoSitePlus
Y60 Phosphorylation PhosphoSitePlus
S61 Phosphorylation O00418 (EEF2K) PhosphoSitePlus   RLIMS-P   UniProt 22216903
K65 Ubiquitination PhosphoSitePlus
S66 Phosphorylation O00418 (EEF2K) PhosphoSitePlus   UniProt 22216903
Y69 Phosphorylation HPRD 17081983
S70 Phosphorylation HPRD   PhosphoSitePlus   UniProt 23186163, 17081983
S71 Phosphorylation PhosphoSitePlus
S72 Phosphorylation P42345 (MTOR) HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 21659604
S74 Phosphorylation P42345 (MTOR) HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 21659604
S78 Phosphorylation O00418 (EEF2K) , P54646 (PRKAA2) , Q13131 (PRKAA1) , Q96QT4 (TRPM7) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 22669845, 14684180, 23186163, ...14709557, 22216903, 22329831, 21112387, 15024086
S135 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 17287340
K162 Ubiquitination PhosphoSitePlus
R178 Methylation PhosphoSitePlus
K238 Ubiquitination PhosphoSitePlus
S241 Phosphorylation PhosphoSitePlus
S243 Phosphorylation PhosphoSitePlus   UniProt 23186163
T340 Phosphorylation PhosphoSitePlus
K341 Ubiquitination PhosphoSitePlus
S345 Phosphorylation PhosphoSitePlus   RLIMS-P 22216903
K347 Ubiquitination PhosphoSitePlus
T348 Phosphorylation O00418 (EEF2K) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 22669845, 22329831, 24275569, ...27956550, 25670349, 18669648, 22115317, 22216903, 23186163, 20068231
T353 Phosphorylation O00418 (EEF2K) neXtProt   PhosphoSitePlus   RLIMS-P   UniProt 22669845, 23186163, 22115317, ...22216903, 22329831
S359 Phosphorylation P06493 (CDK1) , O15264 (MAPK13) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 18337751, 11500363, 12171600, ...22216903
T364 Phosphorylation PhosphoSitePlus
S366 Phosphorylation Q15418 (RPS6KA1) , Q13131 (PRKAA1) , P17612 (PRKACA) , P54646 (PRKAA2) , O00418 (EEF2K) , P23443 (RPS6KB1) , Q9UBS0 (RPS6KB2) HPRD   neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 16171514, 22669845, 22329831, ...20837011, 14709557, 22216903, 11500364, 15024086, 11171059
S377 Phosphorylation Q16644 (MAPKAPK3) , P49137 (MAPKAPK2) , Q8IW41 (MAPKAPK5) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus 12171600
S380 Phosphorylation PhosphoSitePlus
S392 Phosphorylation PhosphoSitePlus
S395 Phosphorylation PhosphoSitePlus
S396 Phosphorylation P45984 (MAPK9) , P45983 (MAPK8) , P53778 (MAPK12) , Q15759 (MAPK11) , O15264 (MAPK13) , O00418 (EEF2K) , Q16539 (MAPK14) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus 12171600, 11500363, 14709557
S398 Phosphorylation Q13131 (PRKAA1) , A0A0A0N0L1 (AMPK alpha 2) , P54646 (PRKAA2) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 20472894, 22669845, 22749997, ...23182879, 14709557, 15024086
S399 Phosphorylation PhosphoSitePlus
T401 Phosphorylation PhosphoSitePlus
S416 Phosphorylation PhosphoSitePlus
S435 Phosphorylation PhosphoSitePlus   UniProt 23186163
S438 Phosphorylation PhosphoSitePlus
S441 Phosphorylation O00418 (EEF2K) neXtProt   PhosphoSitePlus 22669845, 22329831, 22216903
Y443 Phosphorylation PhosphoSitePlus
S445 Phosphorylation O00418 (EEF2K) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 22669845, 23186163, 16964243, ...19651622, 24275569, 22216903, 22329831, 20068231
S462 Phosphorylation PhosphoSitePlus
K467 Sumoylation PhosphoSitePlus
Y468 Phosphorylation HPRD   phospho.ELM 18669648
S470 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 17322306, 21406692, ...23186163, 17081983, 18767875, 19651622, 18669648, 19415658, 20068231
S474 Phosphorylation O00418 (EEF2K) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 19413330, 22669845, 23186163, ...17081983, 19651622, 18669648, 24275569, 22216903, 22329831, 19415658, 20068231
S477 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 18669648, 23186163, 22216903
S478 Phosphorylation PhosphoSitePlus
K485 Ubiquitination PhosphoSitePlus
S491 Phosphorylation O00418 (EEF2K) neXtProt   PhosphoSitePlus   RLIMS-P   UniProt 22329831, 22669845, 23186163, ...22216903
S492 Phosphorylation PhosphoSitePlus
S500 Phosphorylation O00418 (EEF2K) , P17612 (PRKACA) HPRD   neXtProt   PhosphoSitePlus   RLIMS-P 22669845, 22329831, 27956550, ...22216903, 11171059
K516 Ubiquitination PhosphoSitePlus
K517 Ubiquitination PhosphoSitePlus
S521 Phosphorylation PhosphoSitePlus
Y600 Phosphorylation HPRD   PhosphoSitePlus 20068231
K603 Ubiquitination PhosphoSitePlus
S627 Phosphorylation RLIMS-P 22216903
K684 Ubiquitination PhosphoSitePlus


O00418 (EEF2K) as PTM Enzyme



Substrate Site Score Source PMID
O00418 (EEF2K) S61 UniProt 22216903
O00418 (EEF2K) S66 UniProt 22216903
O00418 (EEF2K) S78 neXtProt   UniProt 23186163, 22669845, 22329831, ...22216903
O00418 (EEF2K) T348 neXtProt   PhosphoSitePlus   UniProt 22669845, 22329831, 18669648, ...22216903
O00418 (EEF2K) T353 neXtProt   PhosphoSitePlus   UniProt 23186163, 22669845, 22329831, ...22216903
O00418 (EEF2K) S366 neXtProt   PhosphoSitePlus   UniProt 22329831, 22669845, 11500364, ...22216903
O00418 (EEF2K) S396 PhosphoSitePlus 14709557
O00418 (EEF2K) S441 neXtProt   PhosphoSitePlus 22669845, 22329831, 22216903
O00418 (EEF2K) S445 neXtProt   PhosphoSitePlus   Signor   UniProt 22669845, 22329831, 16964243, ...22216903
O00418 (EEF2K) S474 neXtProt   PhosphoSitePlus   UniProt 22669845, 22329831, 17081983, ...22216903
O00418 (EEF2K) S491 neXtProt   UniProt 22329831, 22669845, 23186163, ...22216903
O00418 (EEF2K) S500 neXtProt   PhosphoSitePlus 22669845, 22329831, 22216903
P13639 (EEF2) T54 HPRD 91085562, 20068231
P13639 (EEF2) T57 HPRD   neXtProt   Signor   UniProt 17287340, 18212344, 12171600, ...9133370, 19651622, 18669648, 8386634, 20068231, 18767875, 20166139, 18614030, 11500363, 12194824, 18188169
P13639 (EEF2) T59 HPRD   Signor 19413330, 2261989, 18767875, ...19651622, 18669648, 8386634, 20068231


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000047251 (hEEF2K/Phos:2) pS366 PRO