iPTMnet Report for O00232 (PSMD12)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O00232 / PSD12_HUMAN
Protein Name 26S proteasome non-ATPase regulatory subunit 12
Gene Name Name: PSMD12
Organism Homo sapiens (Human)

PRO ID PR:O00232
DAG View
PRO Name 26S proteasome non-ATPase regulatory subunit 12 (human)
Definition A 26S proteasome non-ATPase regulatory subunit 12 that is encoded in the genome of human.
Short Label hPSMD12
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O00232 (PSMD12) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 19413330, 12665801
Y20 Phosphorylation PhosphoSitePlus
S21 Phosphorylation PhosphoSitePlus
K33 Ubiquitination PhosphoSitePlus
K36 Ubiquitination PhosphoSitePlus
K52 Ubiquitination PhosphoSitePlus
K92 Sumoylation PhosphoSitePlus
K92 Ubiquitination PhosphoSitePlus
K98 Ubiquitination PhosphoSitePlus
K103 Ubiquitination PhosphoSitePlus
Y111 Phosphorylation PhosphoSitePlus
K121 Ubiquitination PhosphoSitePlus
Y137 Phosphorylation PhosphoSitePlus
K147 Ubiquitination PhosphoSitePlus
K153 Ubiquitination PhosphoSitePlus
K160 Ubiquitination PhosphoSitePlus
K179 Ubiquitination PhosphoSitePlus
K212 Acetylation PhosphoSitePlus
K212 Ubiquitination PhosphoSitePlus
T219 Phosphorylation PhosphoSitePlus
K221 Acetylation PhosphoSitePlus   UniProt 19608861
K221 Ubiquitination PhosphoSitePlus
Y227 Phosphorylation PhosphoSitePlus
C255 S-Nitrosylation dbSNO 19483679
K262 Acetylation PhosphoSitePlus
K262 Ubiquitination PhosphoSitePlus
K295 Ubiquitination PhosphoSitePlus
K301 Ubiquitination PhosphoSitePlus
K330 Ubiquitination PhosphoSitePlus
S332 Phosphorylation PhosphoSitePlus
S335 Phosphorylation PhosphoSitePlus
S343 Phosphorylation PhosphoSitePlus
K349 Ubiquitination PhosphoSitePlus
K368 Acetylation PhosphoSitePlus   UniProt 19608861
K368 Ubiquitination PhosphoSitePlus
Y369 Phosphorylation PhosphoSitePlus
Y370 Phosphorylation PhosphoSitePlus
K419 Ubiquitination PhosphoSitePlus
K431 Ubiquitination PhosphoSitePlus
S434 Phosphorylation PhosphoSitePlus
S437 Phosphorylation PhosphoSitePlus
K441 Ubiquitination PhosphoSitePlus
K448 Acetylation PhosphoSitePlus
K448 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y227 Phosphorylation HPRD 18452278
Site PTM Type PTM Enzyme Score Source PMID
Y207 Phosphorylation HPRD 18452278


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
A2 S2 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
Y207 C207 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
K212 N212 Biomuta DOID:363 / uterine cancer [ icgc ]
Y227 C227 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
K262 N262 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
S434 * Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:1612 / breast cancer [ cosmic ]