iPTMnet Report for O00206 (TLR4)
Protein Information
| UniProt AC / UniProt ID | O00206 / TLR4_HUMAN |
| Protein Name | Toll-like receptor 4 precursor |
| Gene Name | Name: TLR4 |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:O00206 |
| PRO Name | Toll-like receptor 4 (human) |
| Definition | A Toll-like receptor 4 that is encoded in the genome of human. |
| Short Label | hTLR4 |
| Category | organism-gene |
DAG ViewO00206 (TLR4) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| N35 | N-Glycosylation | score4 | GlyGen UniProt | 22363519, 11706042, 17803912 | ||
| N173 | N-Glycosylation | score4 | GlyGen UniProt | 22363519, 11706042, 17803912, ... | ||
| T175 | Phosphorylation | score1 | PhosphoSitePlus | |||
| N205 | N-Glycosylation | score4 | GlyGen UniProt | 11706042, 17803912, 19252480 | ||
| N282 | N-Glycosylation | score3 | GlyGen UniProt | 11706042 | ||
| N309 | N-Glycosylation | score3 | GlyGen UniProt | 11706042 | ||
| N497 | N-Glycosylation | score4 | GlyGen UniProt | 11706042, 19252480 | ||
| N526 | N-Glycosylation | score4 | GlyGen UniProt | 11706042, 19252480 | ||
| Y551 | Phosphorylation | score1 | PhosphoSitePlus | |||
| N575 | N-Glycosylation | score4 | GlyGen UniProt | 11706042, 19252480 | ||
| N624 | N-Glycosylation | score3 | GlyGen UniProt | 11706042 | ||
| Y674 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y680 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S730 | Phosphorylation | score1 | PhosphoSitePlus | |||
| R731 | Methylation | score1 | PhosphoSitePlus | |||
| S738 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S790 | Phosphorylation | score3 | neXtProt PhosphoSitePlus | 20557879 | ||
| S790 | Phosphorylation | Q15139 (PRKD1) | score3 | neXtProt PhosphoSitePlus | 20557879 | |
| S800 | Phosphorylation | score1 | PhosphoSitePlus | |||
| R812 | Methylation | score1 | PhosphoSitePlus |
|
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| N35 | N-Glycosylation | score3 | PRO | 11706042, 19252480 | ||
| N173 | N-Glycosylation | score3 | PRO | 11706042, 19252480 | ||
| N205 | N-Glycosylation | score3 | PRO | 11706042, 19252480 | ||
| N282 | N-Glycosylation | score3 | PRO | 11706042, 19252480 | ||
| N309 | N-Glycosylation | score3 | PRO | 11706042, 19252480 | ||
| N497 | N-Glycosylation | score3 | PRO | 11706042, 19252480 | ||
| N526 | N-Glycosylation | score3 | PRO | 11706042, 19252480 | ||
| N575 | N-Glycosylation | score3 | PRO | 11706042, 19252480 | ||
| N624 | N-Glycosylation | score3 | PRO | 11706042, 19252480 | ||
| S730 | Phosphorylation | score0 | HPRD | 20058876 |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| N173 | K173 | Biomuta | DOID:184 / bone cancer [ cosmic ] | |
| T175 | N175 | Biomuta | DOID:8618 / oral cavity cancer [ cosmic ] | |
| T175 | A175 | Biomuta | [ cosmic ] | |
| N282 | S282 | Biomuta | DOID:2394 / ovarian cancer [ cosmic, icgc ] | |
| N526 | Y526 | Biomuta | DOID:4159 / skin cancer [ cosmic, icgc ] | |
| N624 | K624 | Biomuta | DOID:363 / uterine cancer [ icgc ] | |
| S690 | R690 | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
| S730 | R730 | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
| R731 | Q731 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] DOID:4159 / skin cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ] | |
| R731 | * | Biomuta | DOID:4606 / bile duct cancer [ cosmic ] | |
| S738 | F738 | Biomuta | [ cosmic ] DOID:10534 / stomach cancer [ cosmic ] | |
| S790 | N790 | Biomuta | DOID:1324 / lung cancer [ cosmic, icgc ] | |
| S790 | R790 | Biomuta | DOID:1612 / breast cancer [ cosmic, icgc ] |
