Protein Information

Cytoscape View


UniProt AC / UniProt ID O00206 / TLR4_HUMAN
Protein Name Toll-like receptor 4 precursor
Gene Name Name: TLR4
Organism Homo sapiens (Human)

PRO ID PR:O00206
DAG View
PRO Name Toll-like receptor 4 (human)
Definition A Toll-like receptor 4 that is encoded in the genome of human.
Short Label hTLR4
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O00206 (TLR4) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
N35 N-Glycosylation UniProt 22363519, 11706042, 17803912
N173 N-Glycosylation UniProt 22363519, 11706042, 17803912, ...19252480
T175 Phosphorylation PhosphoSitePlus
N205 N-Glycosylation UniProt 11706042, 17803912, 19252480
N282 N-Glycosylation UniProt 11706042
N309 N-Glycosylation UniProt 11706042
N497 N-Glycosylation UniProt 11706042, 19252480
N526 N-Glycosylation UniProt 11706042, 19252480
Y551 Phosphorylation PhosphoSitePlus
N575 N-Glycosylation UniProt 11706042, 19252480
N624 N-Glycosylation UniProt 11706042
Y674 Phosphorylation PhosphoSitePlus
Y680 Phosphorylation PhosphoSitePlus
S730 Phosphorylation PhosphoSitePlus
S738 Phosphorylation PhosphoSitePlus
S790 Phosphorylation Q15139 (PRKD1) neXtProt   PhosphoSitePlus 20557879
S800 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
N35 N-Glycosylation PRO 11706042, 19252480
N173 N-Glycosylation PRO 11706042, 19252480
N205 N-Glycosylation PRO 11706042, 19252480
N282 N-Glycosylation PRO 11706042, 19252480
N309 N-Glycosylation PRO 11706042, 19252480
N497 N-Glycosylation PRO 11706042, 19252480
N526 N-Glycosylation PRO 11706042, 19252480
N575 N-Glycosylation PRO 11706042, 19252480
N624 N-Glycosylation PRO 11706042, 19252480
S730 Phosphorylation HPRD 20058876
Site PTM Type PTM Enzyme Score Source PMID
S690 Phosphorylation HPRD 20058876
Site PTM Type PTM Enzyme Score Source PMID
S530 Phosphorylation HPRD 20058876


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q03135 (CAV1) Y14 O00206 (TLR4) unknown eFIP 24244013


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
N173 K173 Biomuta DOID:184 / bone cancer [ icgc ] DOID:3371 / chondrosarcoma [ cosmic ]
T175 N175 Biomuta DOID:2596 / larynx cancer [ cosmic ]
N282 S282 Biomuta DOID:2394 / ovarian cancer [ tcga ] DOID:2994 / germ cell cancer [ cosmic ]
N526 Y526 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
N624 K624 Biomuta DOID:363 / uterine cancer [ tcga ]
Y680 * Biomuta DOID:363 / uterine cancer [ tcga ]
S730 R730 Biomuta DOID:1324 / lung cancer [ cosmic ]
S738 F738 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S790 N790 Biomuta DOID:1324 / lung cancer [ cosmic, tcga ]
S790 R790 Biomuta DOID:1612 / breast cancer [ icgc, tcga ]