iPTMnet Report for O00161 (SNAP23)
Protein Information
| UniProt AC / UniProt ID | O00161 / SNP23_HUMAN |
| Protein Name | Synaptosomal-associated protein 23 |
| Gene Name | Name: SNAP23 |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:O00161 |
| PRO Name | synaptosomal-associated protein 23 (human) |
| Definition | A synaptosomal-associated protein 23 that is encoded in the genome of human. |
| Short Label | hSNAP23 |
| Category | organism-gene |
DAG ViewO00161 (SNAP23) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| M1 | Acetylation | score1 | UniProt | 19413330, 21406692, 22814378, ... | ||
| S5 | Phosphorylation | score4 | PhosphoSitePlus RLIMS-P UniProt | 23186163, 29339438 | ||
| S6 | Phosphorylation | score4 | PhosphoSitePlus RLIMS-P UniProt | 23186163, 29339438 | ||
| T17 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S20 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163, 24275569 | ||
| S23 | Phosphorylation | score3 | phospho.ELM PhosphoSitePlus RLIMS-P Signor | 12930825 | ||
| S23 | Phosphorylation | P17252 (PRKCA) | score1 | Signor | 12930825 | |
| T24 | Phosphorylation | score3 | phospho.ELM PhosphoSitePlus RLIMS-P Signor | 12930825 | ||
| T24 | Phosphorylation | P17252 (PRKCA) | score1 | Signor | 12930825 | |
| S34 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 21406692, 23186163 | ||
| K40 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K49 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K64 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K71 | Ubiquitination | score1 | PhosphoSitePlus | |||
| T72 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K91 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S95 | Phosphorylation | score4 | PRO PhosphoSitePlus RLIMS-P+ RLIMS-P | 32949647, 29771640, 28067230 | ||
| S95 | Phosphorylation | P14618 (PKM) | score2 | RLIMS-P+ | 28067230 | |
| K97 | Ubiquitination | score1 | PhosphoSitePlus | |||
| Y99 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K100 | Ubiquitination | score1 | PhosphoSitePlus | |||
| T102 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S110 | Phosphorylation | score4 | phospho.ELM PhosphoSitePlus RLIMS-P UniProt | 21406692, 23186163, 20967886, ... | ||
| C112 | S-Nitrosylation | score0 | dbSNO | 2212679, 22126794, 26338901 | ||
| K117 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S136 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y139 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K141 | Ubiquitination | score1 | PhosphoSitePlus | |||
| T144 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T157 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S161 | Phosphorylation | score4 | phospho.ELM PhosphoSitePlus RLIMS-P Signor UniProt | 12930825, 24275569 | ||
| S161 | Phosphorylation | P17252 (PRKCA) | score1 | Signor | 12930825 | |
| K185 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K190 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S211 | Phosphorylation | score1 | PhosphoSitePlus |
|
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| S5 | Phosphorylation | score0 | HPRD | 18578522, 20068231 | ||
| S6 | Phosphorylation | score0 | HPRD | 18691976, 18578522 | ||
| S20 | Phosphorylation | score0 | HPRD | 19651622, 18578522, 20068231 | ||
| S23 | Phosphorylation | score2 | HPRD | 12930825, 20068231 | ||
| S23 | Phosphorylation | P17252 (PRKCA) | score2 | HPRD | 12930825, 20068231 | |
| T24 | Phosphorylation | score2 | HPRD | 19651622, 12930825 | ||
| T24 | Phosphorylation | P17252 (PRKCA) | score2 | HPRD | 19651622, 12930825 | |
| S34 | Phosphorylation | score0 | HPRD | 18578522 | ||
| T102 | Phosphorylation | score0 | HPRD | 19413330 | ||
| S110 | Phosphorylation | score0 | HPRD | 19413330, 18578522, 19664994, ... | ||
| S161 | Phosphorylation | score2 | HPRD | 20166139, 12930825, 18578522 | ||
| S161 | Phosphorylation | P17252 (PRKCA) | score2 | HPRD | 20166139, 12930825, 18578522 |
|
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| S5 | Phosphorylation | score0 | HPRD | 18578522, 20068231 | ||
| S6 | Phosphorylation | score0 | HPRD | 18691976, 18578522 | ||
| S20 | Phosphorylation | score0 | HPRD | 19651622, 18578522, 20068231 | ||
| S23 | Phosphorylation | score2 | HPRD | 12930825, 20068231 | ||
| S23 | Phosphorylation | P17252 (PRKCA) | score2 | HPRD | 12930825, 20068231 | |
| T24 | Phosphorylation | score2 | HPRD | 19651622, 12930825 | ||
| T24 | Phosphorylation | P17252 (PRKCA) | score2 | HPRD | 19651622, 12930825 | |
| S34 | Phosphorylation | score0 | HPRD | 18578522 | ||
| S108 | Phosphorylation | score2 | HPRD | 20166139, 12930825, 18578522 | ||
| S108 | Phosphorylation | P17252 (PRKCA) | score2 | HPRD | 20166139, 12930825, 18578522 |
Proteoforms
| PRO ID (Short Label) | Sites | PTM Enzyme | Source | PMID | |
|---|---|---|---|---|---|
| PR:000049302 (hSNAP23/Phos:1) | pS95 | PRO |
PTM-dependent PPI
|
PTM type | Substrate | Site | Interactant | Association type | Source | PMID |
|---|---|---|---|---|---|---|---|
| Phosphorylation | O00161 (SNAP23) | S110 | P08962 (CD63) | increased_association | eFIP | 29339438 | |
| Phosphorylation | O00161 (SNAP23) | S161 | Q12846 (STX4) | inhibited_association | eFIP | 12930825 | |
| Phosphorylation | O00161 (SNAP23) | S95 | P14618 (PKM) | unknown | eFIP | 28067230 |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| S5 | T5 | Biomuta | DOID:10534 / stomach cancer [ cosmic ] | |
| K91 | N91 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic ] | |
| T102 | P102 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] |
