iPTMnet Report for O00161 (SNAP23)
Protein Information
UniProt AC / UniProt ID | O00161 / SNP23_HUMAN |
Protein Name | Synaptosomal-associated protein 23 |
Gene Name | Name: SNAP23 |
Organism | Homo sapiens (Human) |
PRO ID | PR:O00161 |
PRO Name | synaptosomal-associated protein 23 (human) |
Definition | A synaptosomal-associated protein 23 that is encoded in the genome of human. |
Short Label | hSNAP23 |
Category | organism-gene |
O00161 (SNAP23) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
M1 | Acetylation | score1 | UniProt | 19413330, 21406692, 22814378, ... | ||
S5 | Phosphorylation | score4 | PhosphoSitePlus RLIMS-P UniProt | 23186163, 29339438 | ||
S6 | Phosphorylation | score4 | PhosphoSitePlus RLIMS-P UniProt | 23186163, 29339438 | ||
T17 | Phosphorylation | score1 | PhosphoSitePlus | |||
S20 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163, 24275569 | ||
S23 | Phosphorylation | score3 | phospho.ELM PhosphoSitePlus RLIMS-P Signor | 12930825 | ||
S23 | Phosphorylation | P17252 (PRKCA) | score1 | Signor | 12930825 | |
T24 | Phosphorylation | score3 | phospho.ELM PhosphoSitePlus RLIMS-P Signor | 12930825 | ||
T24 | Phosphorylation | P17252 (PRKCA) | score1 | Signor | 12930825 | |
S34 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 21406692, 23186163 | ||
K40 | Ubiquitination | score1 | PhosphoSitePlus | |||
K49 | Ubiquitination | score1 | PhosphoSitePlus | |||
K64 | Ubiquitination | score1 | PhosphoSitePlus | |||
K71 | Ubiquitination | score1 | PhosphoSitePlus | |||
T72 | Phosphorylation | score1 | PhosphoSitePlus | |||
K91 | Ubiquitination | score1 | PhosphoSitePlus | |||
S95 | Phosphorylation | score4 | PRO PhosphoSitePlus RLIMS-P+ RLIMS-P | 32949647, 29771640, 28067230 | ||
S95 | Phosphorylation | P14618 (PKM) | score2 | RLIMS-P+ | 28067230 | |
K97 | Ubiquitination | score1 | PhosphoSitePlus | |||
Y99 | Phosphorylation | score1 | PhosphoSitePlus | |||
K100 | Ubiquitination | score1 | PhosphoSitePlus | |||
T102 | Phosphorylation | score1 | PhosphoSitePlus | |||
S110 | Phosphorylation | score4 | phospho.ELM PhosphoSitePlus RLIMS-P UniProt | 21406692, 23186163, 20967886, ... | ||
C112 | S-Nitrosylation | score0 | dbSNO | 2212679, 22126794, 26338901 | ||
K117 | Ubiquitination | score1 | PhosphoSitePlus | |||
S136 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y139 | Phosphorylation | score1 | PhosphoSitePlus | |||
K141 | Ubiquitination | score1 | PhosphoSitePlus | |||
T144 | Phosphorylation | score1 | PhosphoSitePlus | |||
T157 | Phosphorylation | score1 | PhosphoSitePlus | |||
S161 | Phosphorylation | score4 | phospho.ELM PhosphoSitePlus RLIMS-P Signor UniProt | 12930825, 24275569 | ||
S161 | Phosphorylation | P17252 (PRKCA) | score1 | Signor | 12930825 | |
K185 | Ubiquitination | score1 | PhosphoSitePlus | |||
K190 | Ubiquitination | score1 | PhosphoSitePlus | |||
S211 | Phosphorylation | score1 | PhosphoSitePlus |
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
S5 | Phosphorylation | score0 | HPRD | 18578522, 20068231 | ||
S6 | Phosphorylation | score0 | HPRD | 18691976, 18578522 | ||
S20 | Phosphorylation | score0 | HPRD | 19651622, 18578522, 20068231 | ||
S23 | Phosphorylation | score2 | HPRD | 12930825, 20068231 | ||
S23 | Phosphorylation | P17252 (PRKCA) | score2 | HPRD | 12930825, 20068231 | |
T24 | Phosphorylation | score2 | HPRD | 19651622, 12930825 | ||
T24 | Phosphorylation | P17252 (PRKCA) | score2 | HPRD | 19651622, 12930825 | |
S34 | Phosphorylation | score0 | HPRD | 18578522 | ||
T102 | Phosphorylation | score0 | HPRD | 19413330 | ||
S110 | Phosphorylation | score0 | HPRD | 19413330, 18578522, 19664994, ... | ||
S161 | Phosphorylation | score2 | HPRD | 20166139, 12930825, 18578522 | ||
S161 | Phosphorylation | P17252 (PRKCA) | score2 | HPRD | 20166139, 12930825, 18578522 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
S5 | Phosphorylation | score0 | HPRD | 18578522, 20068231 | ||
S6 | Phosphorylation | score0 | HPRD | 18691976, 18578522 | ||
S20 | Phosphorylation | score0 | HPRD | 19651622, 18578522, 20068231 | ||
S23 | Phosphorylation | score2 | HPRD | 12930825, 20068231 | ||
S23 | Phosphorylation | P17252 (PRKCA) | score2 | HPRD | 12930825, 20068231 | |
T24 | Phosphorylation | score2 | HPRD | 19651622, 12930825 | ||
T24 | Phosphorylation | P17252 (PRKCA) | score2 | HPRD | 19651622, 12930825 | |
S34 | Phosphorylation | score0 | HPRD | 18578522 | ||
S108 | Phosphorylation | score2 | HPRD | 20166139, 12930825, 18578522 | ||
S108 | Phosphorylation | P17252 (PRKCA) | score2 | HPRD | 20166139, 12930825, 18578522 |
Proteoforms
PRO ID (Short Label) | Sites | PTM Enzyme | Source | PMID | |
---|---|---|---|---|---|
PR:000049302 (hSNAP23/Phos:1) | pS95 | PRO |
PTM-dependent PPI
PTM type | Substrate | Site | Interactant | Association type | Source | PMID | |
---|---|---|---|---|---|---|---|
Phosphorylation | O00161 (SNAP23) | S110 | P08962 (CD63) | increased_association | eFIP | 29339438 | |
Phosphorylation | O00161 (SNAP23) | S161 | Q12846 (STX4) | inhibited_association | eFIP | 12930825 | |
Phosphorylation | O00161 (SNAP23) | S95 | P14618 (PKM) | unknown | eFIP | 28067230 |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
S5 | T5 | Biomuta | DOID:10534 / stomach cancer [ cosmic ] | |
K91 | N91 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic ] | |
T102 | P102 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] |