iPTMnet Report for O00161 (SNAP23)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O00161 / SNP23_HUMAN
Protein Name Synaptosomal-associated protein 23
Gene Name Name: SNAP23
Organism Homo sapiens (Human)

PRO ID PR:O00161
DAG View
PRO Name synaptosomal-associated protein 23 (human)
Definition A synaptosomal-associated protein 23 that is encoded in the genome of human.
Short Label hSNAP23
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O00161 (SNAP23) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 19413330, 21406692, 22814378, ...12665801, 22223895, 20068231, 25944712
S5 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 23186163, 29339438
S6 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 23186163, 29339438
T17 Phosphorylation PhosphoSitePlus
S20 Phosphorylation PhosphoSitePlus   UniProt 23186163, 24275569
S23 Phosphorylation P17252 (PRKCA) phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 12930825
T24 Phosphorylation P17252 (PRKCA) phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 12930825
S34 Phosphorylation PhosphoSitePlus   UniProt 21406692, 23186163
K40 Ubiquitination PhosphoSitePlus
K49 Ubiquitination PhosphoSitePlus
K64 Ubiquitination PhosphoSitePlus
K71 Ubiquitination PhosphoSitePlus
T72 Phosphorylation PhosphoSitePlus
K91 Ubiquitination PhosphoSitePlus
S95 Phosphorylation P14618 (PKM) PRO   PhosphoSitePlus   RLIMS-P+   RLIMS-P 32949647, 29771640, 28067230
K97 Ubiquitination PhosphoSitePlus
Y99 Phosphorylation PhosphoSitePlus
K100 Ubiquitination PhosphoSitePlus
T102 Phosphorylation PhosphoSitePlus
S110 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 21406692, 23186163, 20967886, ...18669648, 24275569, 20068231, 29339438
C112 S-Nitrosylation dbSNO 2212679, 22126794, 26338901
K117 Ubiquitination PhosphoSitePlus
S136 Phosphorylation PhosphoSitePlus
Y139 Phosphorylation PhosphoSitePlus
K141 Ubiquitination PhosphoSitePlus
T144 Phosphorylation PhosphoSitePlus
T157 Phosphorylation PhosphoSitePlus
S161 Phosphorylation P17252 (PRKCA) phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 12930825, 24275569
K185 Ubiquitination PhosphoSitePlus
K190 Ubiquitination PhosphoSitePlus
S211 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S5 Phosphorylation HPRD 18578522, 20068231
S6 Phosphorylation HPRD 18691976, 18578522
S20 Phosphorylation HPRD 19651622, 18578522, 20068231
S23 Phosphorylation P17252 (PRKCA) HPRD 12930825, 20068231
T24 Phosphorylation P17252 (PRKCA) HPRD 19651622, 12930825
S34 Phosphorylation HPRD 18578522
T102 Phosphorylation HPRD 19413330
S110 Phosphorylation HPRD 19413330, 18578522, 19664994, ...18669648, 19415658, 20068231
S161 Phosphorylation P17252 (PRKCA) HPRD 20166139, 12930825, 18578522
Site PTM Type PTM Enzyme Score Source PMID
S5 Phosphorylation HPRD 18578522, 20068231
S6 Phosphorylation HPRD 18691976, 18578522
S20 Phosphorylation HPRD 19651622, 18578522, 20068231
S23 Phosphorylation P17252 (PRKCA) HPRD 12930825, 20068231
T24 Phosphorylation P17252 (PRKCA) HPRD 19651622, 12930825
S34 Phosphorylation HPRD 18578522
S108 Phosphorylation P17252 (PRKCA) HPRD 20166139, 12930825, 18578522


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000049302 (hSNAP23/Phos:1) pS95 PRO


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation O00161 (SNAP23) S110 P08962 (CD63) increased_association eFIP 29339438
Phosphorylation O00161 (SNAP23) S161 Q12846 (STX4) inhibited_association eFIP 12930825
Phosphorylation O00161 (SNAP23) S95 P14618 (PKM) unknown eFIP 28067230


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S5 T5 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K91 N91 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic ]
T102 P102 Biomuta DOID:9256 / colorectal cancer [ cosmic ]