iPTMnet Report for O00115 (DNASE2)
Protein Information
UniProt AC / UniProt ID | O00115 / DNS2A_HUMAN |
Protein Name | Deoxyribonuclease-2-alpha precursor |
Gene Name | Name: DNASE2 Synonyms:DNASE2A,DNL2; |
Organism | Homo sapiens (Human) |
PRO ID | PR:O00115 |
PRO Name | deoxyribonuclease-2-alpha (human) |
Definition | A deoxyribonuclease-2-alpha that is encoded in the genome of human. |
Short Label | hDNASE2 |
Category | organism-gene |
O00115 (DNASE2) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
Y20 | Phosphorylation | score1 | PhosphoSitePlus | |||
S41 | Phosphorylation | score1 | PhosphoSitePlus | |||
K52 | Ubiquitination | score1 | PhosphoSitePlus | |||
S70 | Phosphorylation | score1 | PhosphoSitePlus | |||
N86 | N-Glycosylation | score1 | GlyGen | 29741879, 24190977 | ||
N212 | N-Glycosylation | score2 | GlyGen UniProt | 12754519, 19159218, 24190977 | ||
N266 | N-Glycosylation | score1 | GlyGen | 23090970, 29741879, 24190977 | ||
N290 | N-Glycosylation | score1 | GlyGen | 23090970, 24190977 | ||
R321 | Methylation | score1 | PhosphoSitePlus | |||
K335 | Acetylation | score1 | PhosphoSitePlus | |||
K353 | Acetylation | score1 | PhosphoSitePlus | |||
S355 | Phosphorylation | score1 | PhosphoSitePlus |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
N86 | S86 | Biomuta | DOID:3571 / liver cancer [ cosmic, icgc ] | |
N266 | T266 | Biomuta | DOID:9256 / colorectal cancer [ icgc ] | |
R321 | W321 | Biomuta | DOID:1324 / lung cancer [ cosmic, icgc ] | |
R321 | Q321 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] |