iPTMnet Report for O00115 (DNASE2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O00115 / DNS2A_HUMAN
Protein Name Deoxyribonuclease-2-alpha precursor
Gene Name Name: DNASE2
Synonyms:DNASE2A,DNL2;
Organism Homo sapiens (Human)

PRO ID PR:O00115
DAG View
PRO Name deoxyribonuclease-2-alpha (human)
Definition A deoxyribonuclease-2-alpha that is encoded in the genome of human.
Short Label hDNASE2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O00115 (DNASE2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y20 Phosphorylation PhosphoSitePlus
S41 Phosphorylation PhosphoSitePlus
K52 Ubiquitination PhosphoSitePlus
S70 Phosphorylation PhosphoSitePlus
N86 N-Glycosylation GlyGen 29741879, 24190977
N212 N-Glycosylation GlyGen   UniProt 12754519, 19159218, 24190977
N266 N-Glycosylation GlyGen 23090970, 29741879, 24190977
N290 N-Glycosylation GlyGen 23090970, 24190977
R321 Methylation PhosphoSitePlus
K335 Acetylation PhosphoSitePlus
K353 Acetylation PhosphoSitePlus
S355 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
N86 S86 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
N266 T266 Biomuta DOID:9256 / colorectal cancer [ icgc ]
R321 W321 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
R321 Q321 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]