iPTMnet Report for A2PYH4 (HFM1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID A2PYH4 / HFM1_HUMAN
Protein Name Probable ATP-dependent DNA helicase HFM1
Gene Name Name: HFM1
Synonyms:SEC3D1;
Organism Homo sapiens (Human)

PRO ID PR:A2PYH4
DAG View
PRO Name probable ATP-dependent DNA helicase HFM1 (human)
Definition A probable ATP-dependent DNA helicase HFM1 that is encoded in the genome of human.
Short Label hHFM1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


A2PYH4 (HFM1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K65 Ubiquitination PhosphoSitePlus
S307 Phosphorylation PhosphoSitePlus
T393 Phosphorylation PhosphoSitePlus
S545 Phosphorylation PhosphoSitePlus
T556 Phosphorylation PhosphoSitePlus
T670 Phosphorylation PhosphoSitePlus
Y798 Phosphorylation PhosphoSitePlus
T799 Phosphorylation PhosphoSitePlus
S807 Phosphorylation PhosphoSitePlus
K1053 Acetylation PhosphoSitePlus
K1059 Acetylation PhosphoSitePlus
T1112 Phosphorylation PhosphoSitePlus
K1118 Acetylation PhosphoSitePlus
S1123 Phosphorylation PhosphoSitePlus
T1124 Phosphorylation PhosphoSitePlus
K1130 Acetylation PhosphoSitePlus
T1132 Phosphorylation PhosphoSitePlus
T1133 Phosphorylation PhosphoSitePlus
S1135 Phosphorylation PhosphoSitePlus
K1136 Acetylation PhosphoSitePlus
S1171 Phosphorylation PhosphoSitePlus
T1172 Phosphorylation PhosphoSitePlus
S1307 Phosphorylation PhosphoSitePlus
S1323 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K65 E65 Biomuta DOID:4159 / skin cancer [ cosmic ]
S807 T807 Biomuta DOID:1324 / lung cancer [ cosmic ]
K1059 E1059 Biomuta DOID:1324 / lung cancer [ cosmic ]
K1118 E1118 Biomuta DOID:1324 / lung cancer [ cosmic ]
T1132 K1132 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S1135 T1135 Biomuta DOID:3571 / liver cancer [ cosmic ]
S1171 * Biomuta DOID:5041 / esophageal cancer [ cosmic ]