Protein Ontology Report - hBUB1B PR:O60566 - http://purl.obolibrary.org/obo/PR_O60566

This page represents a class of proteins encompassing all the protein products of the BUB1B gene in human .

Ontology Information
PRO ID	PR:O60566 Show OBO stanza / PAF
PRO name	mitotic checkpoint serine/threonine-protein kinase BUB1 beta (human)
Synonyms	PRO-short-label: hBUB1B EXACT: MAD3/BUB1-related protein kinase (human); hBUBR1; mitotic checkpoint kinase MAD3L (human); protein SSK1 (human) Gene-based: BUB1B; BUBR1; MAD3L; SSK1
Definition	A mitotic checkpoint serine/threonine-protein kinase BUB1 beta that is encoded in the genome of human. [PRO:DNx, UniProtKB:O60566]
PRO Category	organism-gene
Parent	PR:000004855 mitotic checkpoint serine/threonine-protein kinase BUB1 beta
Terms by PRO Category	Retrieve All terms OBO Stanza / PAF Organism-Specific Category Number of Terms organism-gene 1 organism-sequence 3 organism-modification 6
Term Hierarchy Visualization	DAG     OLS     Cytoscape

Related Cross References
DB identifiers	DTO:03100051, HGNC:1149, Reactome:R-HSA-141436, UniProtKB:O60566

Interactive Sequence View Select/align proteoforms across species

Protein Forms Display Category: All All organism-gene organism-sequence organism-modification
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

hBUB1B forms found in complexes
hBUB1B Component Complexes PR:000035373 hBUB1B/PhosRes- PR:000035579 BUB1:unphosphoBUB1B complex (human) PR:000035428 hBUB1B/Phos:2 PR:000035577 BUB1:phosphoBUB1B complex (human) PR:O60566 hBUB1B PR:000035563 BUB1B:BUB3 complex (human) PR:O60566 hBUB1B PR:000035511 BUB1B:BUB3:MAD2:CDC20 complex (human) PR:O60566 hBUB1B PR:000035575 BUB1B:CDC20 complex (human)

Functional Annotation PRO Centric View GO Centric View

PRO Term GO Annotation Evidence PR:000035362 hBUB1B/Phos:1 Thr-620, MOD:00047 capable_of GO:0005515 protein binding increased relative to PR:000035373 hBUB1B/PhosRes- with PR:P53350 hPLK1 PMID:17785528 PR:000035432 hBUB1B/Phos:3 Thr-608, MOD:00047 located_in GO:0000776 kinetochore PMID:22801780 participates_in GO:0031577 spindle checkpoint signaling increased relative to PR:000035373 hBUB1B/PhosRes- PMID:22801780 participates_in GO:0001933 negative regulation of protein phosphorylation decreased relative to PR:000035373 hBUB1B/PhosRes- PMID:22801780 participates_in GO:0034501 protein localization to kinetochore increased relative to PR:000035373 hBUB1B/PhosRes- PMID:22801780 participates_in GO:0034501 protein localization to kinetochore increased relative to PR:000035373 hBUB1B/PhosRes- PMID:22801780 participates_in GO:0007059 chromosome segregation increased relative to PR:000035373 hBUB1B/PhosRes- PMID:22801780 participates_in GO:0051310 metaphase plate congression increased relative to PR:000035373 hBUB1B/PhosRes- PMID:22801780 PR:000035435 hBUB1B/Phos:4 Ser-543/Ser-670/Ser-1043, MOD:00046 located_in GO:0000776 kinetochore PMID:19015317 participates_in GO:0008608 attachment of spindle microtubules to kinetochore increased relative to PR:000035373 hBUB1B/PhosRes- PMID:19015317, PMID:20016069 participates_in GO:0051310 metaphase plate congression increased relative to PR:000035373 hBUB1B/PhosRes- PMID:20016069 PR:000035373 hBUB1B/PhosRes- capable_of GO:0005515 protein binding with PR:000035669 hPLK1/PhosRes- PMID:19503101 located_in GO:0005813 centrosome PMID:19503101 located_in GO:0000776 kinetochore PMID:22801780 participates_in GO:0001933 negative regulation of protein phosphorylation PMID:22801780 participates_in GO:0033673 negative regulation of kinase activity PMID:19503101 participates_in GO:0010826 negative regulation of centrosome duplication PMID:19503101 PR:O60566 hBUB1B capable_of GO:0005515 protein binding with PR:O15379 hHDAC3 MINT:MINT-7302235 capable_of GO:0005515 protein binding with PR:000035450 hCDC27/PhosRes- PMID:11030144 capable_of GO:0005515 protein binding with PR:Q9H4B4 hPLK3 PMID:15190214 capable_of GO:0005515 protein binding with PR:O43683 hBUB1 PMID:11792804 capable_of GO:0005515 protein binding with PR:Q9NQS7 hINCENP PMID:16760428, PMID:17785528 capable_of GO:0005515 protein binding with PR:P04637-1 hTP53/iso:1 PMID:17671183 capable_of GO:0005515 protein binding with PR:Q92831 hKAT2B MINT:MINT-7299740 capable_of GO:0005515 protein binding with PR:Q12834 hCDC20 PMID:11030144, PMID:20624902 capable_of GO:0005515 protein binding with PR:P09874 hPARP1 BioGRID:BG-480411 capable_of GO:0005515 protein binding with PR:O76070 hSNCG BioGRID:BG-253351 capable_of GO:0005515 protein binding with PR:P04049 hRAF1 PMID:20703093 capable_of GO:0005515 protein binding with PR:Q96IF1 hAJUBA BioGRID:BG-717913 capable_of GO:0005515 protein binding with PR:P25054 hAPC BioGRID:BG-302963 capable_of GO:0005515 protein binding with PR:Q8NG31 hKNL1 BioGRID:BG-697203 capable_of GO:0005515 protein binding with PR:P63010 hAP2B1 BioGRID:BG-283405 capable_of GO:0005515 protein binding with PR:Q13257 hMAD2L1 PMID:20624902 capable_of GO:0005515 protein binding with PR:O15350 hTP73 BioGRID:BG-717441 capable_of GO:0005515 protein binding with PR:Q9H081 hMIS12 BioGRID:BG-715437 capable_of GO:0005515 protein binding with PR:O95997 hPTTG1 BioGRID:BG-721860 capable_of GO:0005515 protein binding with PR:Q92769 hHDAC2 MINT:MINT-7302197 capable_of GO:0005515 protein binding with PR:Q96GD4 hAURKB BioGRID:BG-717911 capable_of GO:0005515 protein binding with PR:P51587 hBRCA2 PMID:10749118 capable_of GO:0016301 kinase activity PMID:11030144 capable_of GO:0005515 protein binding with PR:Q9UJX5 hANAPC4 BioGRID:BG-682429 capable_of GO:0005515 protein binding with PR:Q02224 hCENPE PMID:17785528 capable_of GO:0005515 protein binding with PR:O43684 hBUB3 PMID:20016069 capable_of GO:0005515 protein binding with PR:000035449 hCDC27/Phos:1 PMID:11030144 capable_of GO:0005515 protein binding with PR:Q9UJX3 hANAPC7 BioGRID:BG-316229 capable_of GO:0005515 protein binding with PR:Q13547 hHDAC1 MINT:MINT-7302173 capable_of GO:0005515 protein binding with PR:Q15013 hMAD2L1BP BioGRID:BG-719779 capable_of GO:0005515 protein binding with PR:Q13042 hCDC16 PMID:11030144 capable_of GO:0055105 ubiquitin-protein transferase inhibitor activity PMID:15525512 capable_of GO:0055105 ubiquitin-protein transferase inhibitor activity PMID:15525512 located_in GO:0000939 inner kinetochore PMID:11792804 located_in GO:0005737 cytoplasm PMID:10749118 located_in GO:0000922 spindle pole PMID:15190214 located_in GO:0000776 kinetochore PMID:12719470, PMID:16760428 located_in GO:0000940 outer kinetochore PMID:11792804 participates_in GO:0051987 positive regulation of attachment of spindle microtubules to kinetochore PMID:15592459 participates_in GO:0051444 negative regulation of ubiquitin-protein transferase activity PMID:15525512 participates_in GO:0051444 negative regulation of ubiquitin-protein transferase activity PMID:15525512 participates_in GO:0031577 spindle checkpoint signaling PMID:11030144 participates_in GO:0051310 metaphase plate congression PMID:12719470, PMID:15592459 participates_in NOT GO:0034501 protein localization to kinetochore PMID:16760428 participates_in GO:0031647 regulation of protein stability PMID:17671183 participates_in GO:0006469 negative regulation of protein kinase activity PMID:15592459 PR:000035428 hBUB1B/Phos:2 capable_of GO:0005515 protein binding with PR:Q12834 hCDC20 PMID:11030144 capable_of GO:0005515 protein binding increased relative to PR:000035425 frog-BUB1B/PhosRes- with PR:Q15172 hPPP2R5A PMID:23079597 capable_of GO:0005515 protein binding increased relative to PR:000035425 frog-BUB1B/PhosRes- with PR:O43683 hBUB1 PMID:11792804 capable_of GO:0004672 protein kinase activity increased relative to PR:000035425 frog-BUB1B/PhosRes- PMID:17376779 located_in GO:0000776 kinetochore PMID:17785528 participates_in GO:0051310 metaphase plate congression increased relative to PR:000035425 frog-BUB1B/PhosRes- PMID:17376779, PMID:17785528 participates_in GO:0008608 attachment of spindle microtubules to kinetochore increased relative to PR:000035425 frog-BUB1B/PhosRes- PMID:17785528 participates_in GO:0006974 cellular response to DNA damage stimulus PMID:18440313 Biological Process GO Term Protein Forms & Complexes Evidence GO:0033673 negative regulation of kinase activity PR:000035373 hBUB1B/PhosRes- PMID:19503101 GO:0008608 attachment of spindle microtubules to kinetochore PR:000035428 hBUB1B/Phos:2 increased relative to PR:000035425 frog-BUB1B/PhosRes- PMID:17785528 PR:000035435 hBUB1B/Phos:4 Ser-543/Ser-670/Ser-1043, MOD:00046 increased relative to PR:000035373 hBUB1B/PhosRes- PMID:19015317, PMID:20016069 GO:0006469 negative regulation of protein kinase activity PR:O60566 hBUB1B PMID:15592459 GO:0001933 negative regulation of protein phosphorylation PR:000035373 hBUB1B/PhosRes- PMID:22801780 PR:000035432 hBUB1B/Phos:3 Thr-608, MOD:00047 decreased relative to PR:000035373 hBUB1B/PhosRes- PMID:22801780 NOT GO:0034501 protein localization to kinetochore PR:O60566 hBUB1B PMID:16760428 GO:0031647 regulation of protein stability PR:O60566 hBUB1B PMID:17671183 GO:0007059 chromosome segregation PR:000035432 hBUB1B/Phos:3 Thr-608, MOD:00047 increased relative to PR:000035373 hBUB1B/PhosRes- PMID:22801780 GO:0006974 cellular response to DNA damage stimulus PR:000035428 hBUB1B/Phos:2 PMID:18440313 GO:0051444 negative regulation of ubiquitin-protein transferase activity PR:O60566 hBUB1B PMID:15525512 PR:O60566 hBUB1B PMID:15525512 GO:0034501 protein localization to kinetochore PR:000035432 hBUB1B/Phos:3 Thr-608, MOD:00047 increased relative to PR:000035373 hBUB1B/PhosRes- PMID:22801780 PR:000035432 hBUB1B/Phos:3 Thr-608, MOD:00047 increased relative to PR:000035373 hBUB1B/PhosRes- PMID:22801780 GO:0051987 positive regulation of attachment of spindle microtubules to kinetochore PR:O60566 hBUB1B PMID:15592459 GO:0010826 negative regulation of centrosome duplication PR:000035373 hBUB1B/PhosRes- PMID:19503101 GO:0031577 spindle checkpoint signaling PR:000035432 hBUB1B/Phos:3 Thr-608, MOD:00047 increased relative to PR:000035373 hBUB1B/PhosRes- PMID:22801780 PR:O60566 hBUB1B PMID:11030144 GO:0051310 metaphase plate congression PR:000035428 hBUB1B/Phos:2 increased relative to PR:000035425 frog-BUB1B/PhosRes- PMID:17376779, PMID:17785528 PR:000035432 hBUB1B/Phos:3 Thr-608, MOD:00047 increased relative to PR:000035373 hBUB1B/PhosRes- PMID:22801780 PR:000035435 hBUB1B/Phos:4 Ser-543/Ser-670/Ser-1043, MOD:00046 increased relative to PR:000035373 hBUB1B/PhosRes- PMID:20016069 PR:O60566 hBUB1B PMID:12719470, PMID:15592459 Cellular Location GO Term Protein Forms & Complexes Evidence GO:0000940 outer kinetochore PR:O60566 hBUB1B PMID:11792804 GO:0005813 centrosome PR:000035373 hBUB1B/PhosRes- PMID:19503101 GO:0005737 cytoplasm PR:O60566 hBUB1B PMID:10749118 GO:0000939 inner kinetochore PR:O60566 hBUB1B PMID:11792804 GO:0000776 kinetochore PR:000035373 hBUB1B/PhosRes- PMID:22801780 PR:000035428 hBUB1B/Phos:2 PMID:17785528 PR:000035432 hBUB1B/Phos:3 Thr-608, MOD:00047 PMID:22801780 PR:000035435 hBUB1B/Phos:4 Ser-543/Ser-670/Ser-1043, MOD:00046 PMID:19015317 PR:O60566 hBUB1B PMID:12719470, PMID:16760428 GO:0000922 spindle pole PR:O60566 hBUB1B PMID:15190214

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