Entry Report [PIR] - PR:000035432

Protein Ontology Report - hBUB1B/Phos:3

PR:000035432 - http://purl.obolibrary.org/obo/PR_000035432

Protein Forms Annotations

Ontology Information

PRO ID

PR:000035432 Show OBO stanza / PAF

PRO name

mitotic checkpoint serine/threonine-protein kinase BUB1 beta phosphorylated 3 (human)

Synonyms

PRO-short-label:	hBUB1B/Phos:3
PRO-proteoform-std:	UniProtKB:O60566-1, Thr-608, MOD:00047
RELATED:	BUBR1 phosphorylated (human); hBUBR1 phosphorylated

Definition

A mitotic checkpoint serine/threonine-protein kinase BUB1 beta phosphorylated 3 in human. This phosphorylated form is observed in prometaphase and in conditions of spindle depolymerization (nocodazole). Example: UniProtKB:O60566-1, Thr-608, MOD:00047. [PMID:10593653, PMID:10749118, PMID:22801780, PRO:KER]

Comment

One of the articles cited mentions BUB1B (PR:O60566) as the kinase when bound to CENPE (PR:Q02224).

PRO Category

organism-modification

Parent

PR:000035431 mitotic checkpoint serine/threonine-protein kinase BUB1 beta phosphorylated 3

Term Hierarchy Visualization

DAG

OLS

Cytoscape

Interactive Sequence View Select/align proteoforms across species

Protein Forms

PRO ID & Category Annotation Complex	Name	Short Label	Definition & Comment

Functional Annotation

PRO Centric View
GO Centric View

PRO Term	GO Annotation		Evidence
PR:000035432 hBUB1B/Phos:3 Thr-608, MOD:00047	located_in	GO:0000776 kinetochore	PMID:22801780
	participates_in	GO:0031577 spindle checkpoint signaling increased relative to PR:000035373 hBUB1B/PhosRes-	PMID:22801780
	participates_in	GO:0034501 protein localization to kinetochore increased relative to PR:000035373 hBUB1B/PhosRes-	PMID:22801780
	participates_in	GO:0007059 chromosome segregation increased relative to PR:000035373 hBUB1B/PhosRes-	PMID:22801780
	participates_in	GO:0034501 protein localization to kinetochore increased relative to PR:000035373 hBUB1B/PhosRes-	PMID:22801780
	participates_in	GO:0001933 negative regulation of protein phosphorylation decreased relative to PR:000035373 hBUB1B/PhosRes-	PMID:22801780
	participates_in	GO:0051310 metaphase plate congression increased relative to PR:000035373 hBUB1B/PhosRes-	PMID:22801780

Biological Process GO Term	Protein Forms & Complexes	Evidence
GO:0001933 negative regulation of protein phosphorylation	PR:000035432 hBUB1B/Phos:3 Thr-608, MOD:00047 decreased relative to PR:000035373 hBUB1B/PhosRes-	PMID:22801780
GO:0031577 spindle checkpoint signaling	PR:000035432 hBUB1B/Phos:3 Thr-608, MOD:00047 increased relative to PR:000035373 hBUB1B/PhosRes-	PMID:22801780
GO:0051310 metaphase plate congression	PR:000035432 hBUB1B/Phos:3 Thr-608, MOD:00047 increased relative to PR:000035373 hBUB1B/PhosRes-	PMID:22801780
GO:0007059 chromosome segregation	PR:000035432 hBUB1B/Phos:3 Thr-608, MOD:00047 increased relative to PR:000035373 hBUB1B/PhosRes-	PMID:22801780
GO:0034501 protein localization to kinetochore	PR:000035432 hBUB1B/Phos:3 Thr-608, MOD:00047 increased relative to PR:000035373 hBUB1B/PhosRes-	PMID:22801780
GO:0034501 protein localization to kinetochore	PR:000035432 hBUB1B/Phos:3 Thr-608, MOD:00047 increased relative to PR:000035373 hBUB1B/PhosRes-	PMID:22801780

Cellular Location GO Term	Protein Forms & Complexes	Evidence
GO:0000776 kinetochore	PR:000035432 hBUB1B/Phos:3 Thr-608, MOD:00047	PMID:22801780

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