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Protein Ontology Report - hBUB1B/Phos:4

PR:000035435 - http://purl.obolibrary.org/obo/PR_000035435
Ontology Information
PRO ID PR:000035435 Show OBO stanza / PAF
PRO name mitotic checkpoint serine/threonine-protein kinase BUB1 beta phosphorylated 4 (human)
Synonyms
PRO-short-label: hBUB1B/Phos:4
PRO-proteoform-std: UniProtKB:O60566-1, Ser-543/Ser-670/Ser-1043, MOD:00046
RELATED: BUBR1 phosphorylated (human); hBUBR1 phosphorylated
Definition A mitotic checkpoint serine/threonine-protein kinase BUB1 beta phosphorylated 4 in human. This phosphorylated form is observed in prophase, prometaphase, metaphase, anaphase, spindle depolymerization (nocodazole). This form is not observed when there is a lack of kinetochore tension (taxol). Ser-435, Ser-574 and Ser-720 could also be phosphorylated. Example: UniProtKB:O60566-1, Ser-543/Ser-670/Ser-1043, MOD:00046. [PMID:19015317, PMID:20016069, PRO:KER]
Comment Kinase=("CDK1"; PR:000003271).
PRO Category organism-modification
Parent PR:000035434 mitotic checkpoint serine/threonine-protein kinase BUB1 beta phosphorylated 4
Term Hierarchy Visualization DAG     OLS     Cytoscape

Interactive Sequence View Select/align proteoforms across species

Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

Functional Annotation
PRO Term GO Annotation Evidence
PR:000035435
hBUB1B/Phos:4
Ser-543/Ser-670/Ser-1043, MOD:00046 		located_in GO:0000776 kinetochore PMID:19015317
participates_in GO:0008608 attachment of spindle microtubules to kinetochore increased relative to PR:000035373 hBUB1B/PhosRes- PMID:19015317, PMID:20016069
participates_in GO:0051310 metaphase plate congression increased relative to PR:000035373 hBUB1B/PhosRes- PMID:20016069
Biological Process GO Term Protein Forms & Complexes Evidence
GO:0008608 attachment of spindle microtubules to kinetochore PR:000035435 hBUB1B/Phos:4
Ser-543/Ser-670/Ser-1043, MOD:00046
increased relative to PR:000035373 hBUB1B/PhosRes- 		PMID:19015317, PMID:20016069
GO:0051310 metaphase plate congression PR:000035435 hBUB1B/Phos:4
Ser-543/Ser-670/Ser-1043, MOD:00046
increased relative to PR:000035373 hBUB1B/PhosRes- 		PMID:20016069
Cellular Location GO Term Protein Forms & Complexes Evidence
GO:0000776 kinetochore PR:000035435 hBUB1B/Phos:4
Ser-543/Ser-670/Ser-1043, MOD:00046
PMID:19015317

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