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Protein Ontology Report - TGFB1

PR:000000182 - http://purl.obolibrary.org/obo/PR_000000182
Ontology Information
PRO ID PR:000000182 Show OBO stanza / PAF
PRO name TGF-beta 1
Synonyms
PRO-short-label: TGFB1
EXACT: TGF-beta-1
Gene-based: TGFB
Definition A TGF-beta that is a translation product of the human TGFB1 gene or a 1:1 ortholog thereof. [PRO:CNA]
PRO Category gene
Parent PR:000000046 TGF-beta
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Independent Organism-Specific
Category Number of Terms Category Number of Terms
gene 1 organism-gene 5
sequence 1 organism-sequence 9
modification 7 organism-modification 24
union 0
Term Hierarchy Visualization DAG     OLS     Cytoscape


Interactive Sequence View Select/align proteoforms across species

Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

TGFB1 forms found in complexes
TGFB1 Component Complexes
PR:000000616 TGFB1/iso:1/mature PR:000025925 dimeric TGF-beta 1
PR:000025927 hTGFB1/iso:1/mature PR:000025926 dimeric TGF-beta 1 (human)
PR:000025929 rTGFB1/iso:1/mature PR:000025931 dimeric TGF-beta 1 (rat)

Functional Annotation
PRO Term GO Annotation Evidence
PR:000000620
hTGFB1/var:T81H/Clv:2
Tyr-81, CHEBI:29979 		located_in GO:0005615 extracellular space PMID:12493741
PR:P01137-1
hTGFB1/iso:1
capable_of GO:0042803 protein homodimerization activity PMID:1544940
located_in GO:0005796 Golgi lumen PMID:1544940
participates_in GO:0007179 transforming growth factor beta receptor signaling pathway PMID:1544940
participates_in GO:0043066 negative regulation of apoptotic process PMID:9918798
PR:000000622
hTGFB1/var:R218C/Clv:2
Arg-218, CHEBI:29950 		has_agent SO:0001561 polypeptide_partial_loss_of_function PMID:11278244
PR:000000623
hTGFB1/var:H222D/Clv:1
His-222, CHEBI:29958 		capable_of GO:0008083 growth factor activity increased relative to PR:000000616 TGFB1/iso:1/mature PMID:12493741
located_in GO:0005615 extracellular space PMID:12493741
participates_in GO:0043066 negative regulation of apoptotic process PMID:12493741
participates_in GO:0007179 transforming growth factor beta receptor signaling pathway PMID:12493741
PR:000000624
hTGFB1/var:H222D/Clv:2
His-222, CHEBI:29958 		has_agent SO:0001561 polypeptide_partial_loss_of_function PMID:11278244
has_agent SO:0001601 conformational_change_variant PMID:11278244
PR:000000625
hTGFB1/var:C225R/Clv:1
Cys-225, CHEBI:29952 		capable_of GO:0008083 growth factor activity increased relative to PR:000000616 TGFB1/iso:1/mature PMID:11062463, PMID:12493741, PMID:12843182
located_in GO:0005615 extracellular space PMID:11062463, PMID:12493741, PMID:12843182
PR:000000626
hTGFB1/var:C225R/Clv:2
Cys-225, CHEBI:29952 		has_agent SO:0001561 polypeptide_partial_loss_of_function PMID:11278244
PR:000000621
hTGFB1/var:R218C/Clv:1
Arg-218, CHEBI:29950 		capable_of GO:0005160 transforming growth factor beta receptor binding PMID:11278244
capable_of GO:0008083 growth factor activity increased relative to PR:000000616 TGFB1/iso:1/mature PMID:11062463, PMID:12493741, PMID:12843182
capable_of GO:0042803 protein homodimerization activity PMID:11062463, PMID:12493741, PMID:12843182
located_in GO:0005615 extracellular space PMID:11062463, PMID:12493741, PMID:12843182
participates_in GO:0007179 transforming growth factor beta receptor signaling pathway PMID:11062463, PMID:12493741, PMID:12843182
PR:000000628
hTGFB1/var:R218H/Clv:2
Arg-218, CHEBI:29979 		has_agent SO:0001561 polypeptide_partial_loss_of_function PMID:11278244
has_agent SO:0001601 conformational_change_variant PMID:11278244
PR:000000400
hTGFB1/var:R218C
Arg-218, CHEBI:29950 		associated_with_disease_progression DOID:4997 Camurati-Engelmann disease PMID:10973241, PMID:11062463, PMID:12493741, PMID:12843182
capable_of GO:0008083 growth factor activity increased relative to PR:000002555 TGFB1/iso:1/UnMod PMID:11062463, PMID:12493741, PMID:12843182
participates_in GO:0043066 negative regulation of apoptotic process PMID:11062463, PMID:12493741, PMID:12843182
participates_in GO:0007179 transforming growth factor beta receptor signaling pathway PMID:12843182
PR:000000401
hTGFB1/var:R218H
Arg-218, CHEBI:29979 		associated_with_disease_progression DOID:4997 Camurati-Engelmann disease PMID:12493741
PR:000000402
hTGFB1/var:H222D
His-222, CHEBI:29958 		associated_with_disease_progression DOID:4997 Camurati-Engelmann disease PMID:12493741
participates_in GO:0007179 transforming growth factor beta receptor signaling pathway PMID:12493741
participates_in GO:0043066 negative regulation of apoptotic process PMID:12493741
PR:000000403
hTGFB1/var:C225R
Cys-225, CHEBI:29952 		associated_with_disease_progression DOID:4997 Camurati-Engelmann disease PMID:12493741
capable_of GO:0008083 growth factor activity increased relative to PR:000002555 TGFB1/iso:1/UnMod PMID:11062463, PMID:12493741, PMID:12843182
located_in GO:0005615 extracellular space PMID:11062463, PMID:12493741, PMID:12843182
participates_in GO:0007179 transforming growth factor beta receptor signaling pathway PMID:11062463, PMID:12493741, PMID:12843182
participates_in GO:0043066 negative regulation of apoptotic process PMID:11062463, PMID:12493741, PMID:12843182
PR:000000398
hTGFB1/var:L10P
Leu-10, CHEBI:50342 		participates_in GO:0007179 transforming growth factor beta receptor signaling pathway PMID:9783545
PR:000000399
hTGFB1/var:T81H
Tyr-81, CHEBI:29979 		associated_with_disease_progression DOID:4997 Camurati-Engelmann disease PMID:12493741
has_agent SO:0001558 polypeptide_localization_variant PMID:11062463, PMID:12493741
participates_in GO:0007179 transforming growth factor beta receptor signaling pathway PMID:11062463
PR:000025930
GrMonkey-TGFB1/iso:1/mature
capable_of GO:0042803 protein homodimerization activity PMID:3185545
located_in GO:0031012 extracellular matrix PMID:3185545
participates_in GO:0007179 transforming growth factor beta receptor signaling pathway PMID:3185545
PR:000026335
hTGFB1/iso:1/inactive
Asn-82, MOD:00160 		capable_of NOT GO:0005160 transforming growth factor beta receptor binding PMID:2677679, PMID:3162913
capable_of GO:0042803 protein homodimerization activity PMID:3162913
located_in GO:0031012 extracellular matrix PMID:17015622, PMID:8294500
part_of GO:0032991 protein-containing complex PMID:3162913
participates_in GO:0007179 transforming growth factor beta receptor signaling pathway PMID:3162913
PR:000025928
mTGFB1/iso:1/mature
capable_of GO:0005160 transforming growth factor beta receptor binding PMID:14764882
located_in GO:0031012 extracellular matrix PMID:9008713
participates_in GO:0030879 mammary gland development PMID:1821856
PR:000025929
rTGFB1/iso:1/mature
located_in GO:0031012 extracellular matrix PMID:11907708
PR:000025927
hTGFB1/iso:1/mature
capable_of GO:0042803 protein homodimerization activity PMID:3162913, PMID:8471846
located_in GO:0031012 extracellular matrix PMID:8294500
participates_in GO:0007179 transforming growth factor beta receptor signaling pathway PMID:8471846
participates_in GO:0043066 negative regulation of apoptotic process PMID:9918798
PR:000036529
mTGFB1/iso:1/inactive
Asn-82, MOD:00160 		located_in GO:0031012 extracellular matrix PMID:9008713
participates_in GO:0030879 mammary gland development PMID:1821856
PR:000036526
hTGFB1/iso:1/LAP
Asn-82, MOD:00160 		part_of GO:0032991 protein-containing complex PMID:17015622, PMID:3162913
PR:000036527
GrMonkey-TGFB1/iso:1/inactive
Asn-82, MOD:00160 		capable_of NOT GO:0005160 transforming growth factor beta receptor binding PMID:1448117
part_of GO:0032991 protein-containing complex PMID:1448117, PMID:2677679
participates_in GO:0007179 transforming growth factor beta receptor signaling pathway PMID:1448117, PMID:2677679
PR:000000627
hTGFB1/var:R218H/Clv:1
Arg-218, CHEBI:29979 		capable_of GO:0008083 growth factor activity increased relative to PR:000000616 TGFB1/iso:1/mature PMID:12493741, PMID:12843182
capable_of GO:0005160 transforming growth factor beta receptor binding PMID:11278244
capable_of GO:0042803 protein homodimerization activity PMID:11278244
located_in GO:0005615 extracellular space PMID:11278244
participates_in GO:0007179 transforming growth factor beta receptor signaling pathway PMID:11278244
PR:000000619
hTGFB1/var:T81H/Clv:1
Tyr-81, CHEBI:29979 		has_agent SO:0001558 polypeptide_localization_variant PMID:12493741
PR:000000182
TGFB1
participates_in GO:0030154 cell differentiation PANTHER:PTHR11848:SF32
participates_in GO:0008283 cell population proliferation PANTHER:PTHR11848:SF32
PR:P04202-1
mTGFB1/iso:1
participates_in GO:0030879 mammary gland development PMID:1821856
Biological Process GO Term Protein Forms & Complexes Evidence
GO:0030154 cell differentiation PR:000000182 TGFB1

PANTHER:PTHR11848:SF32
GO:0043066 negative regulation of apoptotic process PR:000000400 hTGFB1/var:R218C
Arg-218, CHEBI:29950
PMID:11062463, PMID:12493741, PMID:12843182
PR:000000402 hTGFB1/var:H222D
His-222, CHEBI:29958
PMID:12493741
PR:000000403 hTGFB1/var:C225R
Cys-225, CHEBI:29952
PMID:11062463, PMID:12493741, PMID:12843182
PR:000000623 hTGFB1/var:H222D/Clv:1
His-222, CHEBI:29958
PMID:12493741
PR:000025927 hTGFB1/iso:1/mature

PMID:9918798
PR:P01137-1 hTGFB1/iso:1

PMID:9918798
GO:0008283 cell population proliferation PR:000000182 TGFB1

PANTHER:PTHR11848:SF32
GO:0007179 transforming growth factor beta receptor signaling pathway PR:000000398 hTGFB1/var:L10P
Leu-10, CHEBI:50342
PMID:9783545
PR:000000399 hTGFB1/var:T81H
Tyr-81, CHEBI:29979
PMID:11062463
PR:000000400 hTGFB1/var:R218C
Arg-218, CHEBI:29950
PMID:12843182
PR:000000402 hTGFB1/var:H222D
His-222, CHEBI:29958
PMID:12493741
PR:000000403 hTGFB1/var:C225R
Cys-225, CHEBI:29952
PMID:11062463, PMID:12493741, PMID:12843182
PR:000000621 hTGFB1/var:R218C/Clv:1
Arg-218, CHEBI:29950
PMID:11062463, PMID:12493741, PMID:12843182
PR:000000623 hTGFB1/var:H222D/Clv:1
His-222, CHEBI:29958
PMID:12493741
PR:000000627 hTGFB1/var:R218H/Clv:1
Arg-218, CHEBI:29979
PMID:11278244
PR:000025927 hTGFB1/iso:1/mature

PMID:8471846
PR:000025930 GrMonkey-TGFB1/iso:1/mature

PMID:3185545
PR:000026335 hTGFB1/iso:1/inactive
Asn-82, MOD:00160
PMID:3162913
PR:000036527 GrMonkey-TGFB1/iso:1/inactive
Asn-82, MOD:00160
PMID:1448117, PMID:2677679
PR:P01137-1 hTGFB1/iso:1

PMID:1544940
GO:0030879 mammary gland development PR:000025928 mTGFB1/iso:1/mature

PMID:1821856
PR:000036529 mTGFB1/iso:1/inactive
Asn-82, MOD:00160
PMID:1821856
PR:P04202-1 mTGFB1/iso:1

PMID:1821856
Cellular Location GO Term Protein Forms & Complexes Evidence
GO:0005796 Golgi lumen PR:P01137-1 hTGFB1/iso:1

PMID:1544940
GO:0031012 extracellular matrix PR:000025927 hTGFB1/iso:1/mature

PMID:8294500
PR:000025928 mTGFB1/iso:1/mature

PMID:9008713
PR:000025929 rTGFB1/iso:1/mature

PMID:11907708
PR:000025930 GrMonkey-TGFB1/iso:1/mature

PMID:3185545
PR:000026335 hTGFB1/iso:1/inactive
Asn-82, MOD:00160
PMID:17015622, PMID:8294500
PR:000036529 mTGFB1/iso:1/inactive
Asn-82, MOD:00160
PMID:9008713
GO:0005615 extracellular space PR:000000403 hTGFB1/var:C225R
Cys-225, CHEBI:29952
PMID:11062463, PMID:12493741, PMID:12843182
PR:000000620 hTGFB1/var:T81H/Clv:2
Tyr-81, CHEBI:29979
PMID:12493741
PR:000000621 hTGFB1/var:R218C/Clv:1
Arg-218, CHEBI:29950
PMID:11062463, PMID:12493741, PMID:12843182
PR:000000623 hTGFB1/var:H222D/Clv:1
His-222, CHEBI:29958
PMID:12493741
PR:000000625 hTGFB1/var:C225R/Clv:1
Cys-225, CHEBI:29952
PMID:11062463, PMID:12493741, PMID:12843182
PR:000000627 hTGFB1/var:R218H/Clv:1
Arg-218, CHEBI:29979
PMID:11278244

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