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Protein Ontology Report - hTGFB1/var:R218C

PR:000000400 - http://purl.obolibrary.org/obo/PR_000000400
Ontology Information
PRO ID PR:000000400 Show OBO stanza / PAF
PRO name TGF-beta 1 sequence variant R218C (human)
Synonyms
PRO-short-label: hTGFB1/var:R218C
EXACT: TGF-beta 1 sequence variant 3 (human)
PRO-proteoform-std: UniProtKB:P01137, Arg-218, CHEBI:29950
Definition A transforming growth factor beta-1 (human) that has a Cys residue at the position equivalent to Arg-218 of the amino acid sequence represented by UniProtKB:P01137. UniProtKB:P01137, Arg-218, CHEBI:29950. [PMID:10973241, PMID:11062463, PMID:12493741, PMID:12843182, PRO:CNA, PRO:DAN]
PRO Category organism-sequence
Parent PR:P01137 transforming growth factor beta-1 (human)
Term Hierarchy Visualization DAG     OLS     Cytoscape


Interactive Sequence View Select/align proteoforms across species

Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

Functional Annotation
PRO Term GO Annotation Evidence
PR:000000400
hTGFB1/var:R218C
Arg-218, CHEBI:29950 		associated_with_disease_progression DOID:4997 Camurati-Engelmann disease PMID:10973241, PMID:11062463, PMID:12493741, PMID:12843182
capable_of GO:0008083 growth factor activity increased relative to PR:000002555 TGFB1/iso:1/UnMod PMID:11062463, PMID:12493741, PMID:12843182
participates_in GO:0043066 negative regulation of apoptotic process PMID:11062463, PMID:12493741, PMID:12843182
participates_in GO:0007179 transforming growth factor beta receptor signaling pathway PMID:12843182
Biological Process GO Term Protein Forms & Complexes Evidence
GO:0043066 negative regulation of apoptotic process PR:000000400 hTGFB1/var:R218C
Arg-218, CHEBI:29950
PMID:11062463, PMID:12493741, PMID:12843182
GO:0007179 transforming growth factor beta receptor signaling pathway PR:000000400 hTGFB1/var:R218C
Arg-218, CHEBI:29950
PMID:12843182

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