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Protein Ontology Report - hTGFB1/var:R218C/Clv:2

PR:000000622 - http://purl.obolibrary.org/obo/PR_000000622
Ontology Information
PRO ID PR:000000622 Show OBO stanza / PAF
PRO name TGF-beta 1 sequence variant R218C cleaved 2 (human)
Synonyms
PRO-short-label: hTGFB1/var:R218C/Clv:2
EXACT: TGF-beta 1 sequence variant 3 cleaved 2 (human)
PRO-proteoform-std: UniProtKB:P01137, 30-278, Arg-218, CHEBI:29950
Definition A TGF-beta 1 sequence variant R218C, signal peptide removed form (human) that has been processed by subsequent removal of the C-terminal mature peptide. This chain is referred as to the latency associated peptide (LAP). This form has decreased affinity for the mature peptide (PR:000000621). UniProtKB:P01137, 30-278, Arg-218, CHEBI:29950. [PMID:10973241, PMID:11062463, PMID:11278244, PMID:12493741, PMID:12843182, PRO:CNA, PRO:DAN]
PRO Category organism-modification
Parent PR:000021904 TGF-beta 1 sequence variant R218C, signal peptide removed form (human)
Term Hierarchy Visualization DAG     OLS     Cytoscape

Interactive Sequence View Select/align proteoforms across species

Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

Functional Annotation
PRO Term GO Annotation Evidence
PR:000000622
hTGFB1/var:R218C/Clv:2
Arg-218, CHEBI:29950
has_agent SO:0001561 polypeptide_partial_loss_of_function PMID:11278244

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