Protein Ontology Report - hTP53 PR:P04637 - http://purl.obolibrary.org/obo/PR_P04637

This page represents a class of proteins encompassing all the protein products of the TP53 gene in human .

Ontology Information
PRO ID	PR:P04637 Show OBO stanza / PAF
PRO name	cellular tumor antigen p53 (human)
Synonyms	PRO-short-label: hTP53 EXACT: antigen NY-CO-13 (human); phosphoprotein p53 (human); tumor suppressor p53 (human) Gene-based: P53; TP53
Definition	A cellular tumor antigen p53 that is encoded in the genome of human. [PRO:CNA, UniProtKB:P04637]
PRO Category	organism-gene
Parent	PR:000003035 cellular tumor antigen p53
Terms by PRO Category	Retrieve All terms OBO Stanza / PAF Organism-Specific Category Number of Terms organism-gene 1 organism-sequence 9 organism-modification 36
Term Hierarchy Visualization	DAG     OLS     Cytoscape

Related Cross References
DB identifiers	HGNC:11998, Reactome:R-HSA-6813797, Reactome:R-HSA-69488, Reactome:R-HSA-8869337, UniProtKB:P04637

Interactive Sequence View Select/align proteoforms across species

Protein Forms Display Category: All All organism-gene organism-sequence organism-modification
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

hTP53 forms found in complexes
hTP53 Component Complexes PR:000027841 hTP53/iso:1/Sumo:1 PR:000027844 p53 complex sumoylated 1 (human) PR:000027846 hTP53/iso:1/UnMod PR:000027844 p53 complex sumoylated 1 (human)

Functional Annotation PRO Centric View GO Centric View

PRO Term GO Annotation Evidence PR:000027766 hTP53/iso:1/Me2:1 Lys-382, MOD:00084 capable_of GO:0005515 protein binding with PR:Q12888 hTP53BP1 PMID:18840612 PR:000027810 hTP53/iso:1/Me:4 Lys-370, MOD:00663 participates_in GO:0045892 negative regulation of transcription, DNA-templated PMID:17108971 PR:000027812 hTP53/iso:1/Ac:2 Lys-382, MOD:00064 participates_in GO:0045893 positive regulation of transcription, DNA-templated PMID:20228809 PR:000027808 hTP53/iso:1/Me:3 Lys-372, MOD:00663 located_in GO:0005634 nucleus PMID:15525938 participates_in GO:0045893 positive regulation of transcription, DNA-templated PMID:15525938 PR:000027814 hTP53/iso:1/Phos:12 Ser-15/Ser-392, MOD:00046 located_in GO:0005634 nucleus PMID:21317932 participates_in GO:0045893 positive regulation of transcription, DNA-templated PMID:21317932 PR:000027774 hTP53/iso:1/Ac:1 Lys-120, MOD:00064 participates_in GO:0043065 positive regulation of apoptotic process PMID:17189187 PR:000027844 p53 complex sumoylated 1 (human) capable_of NOT GO:0003677 DNA binding PMID:19339993 participates_in GO:0045892 negative regulation of transcription, DNA-templated PMID:19339993 PR:000035446 hTP53/iso:1/Phos:1 Ser-15, MOD:00046 located_in GO:0005634 nucleus PMID:11602639 participates_in GO:0006915 apoptotic process PMID:11602639 PR:000036624 hTP53/iso:1/Phos:2 Ser-15/Ser-46, MOD:00046 capable_of GO:0005515 protein binding with PR:000003109 MAPK14/Phos:1 PMID:15642743 participates_in GO:0006915 apoptotic process PMID:15642743 PR:000027839 hTP53/iso:1/Phos:11 Ser-183/Ser-269, MOD:00046|Thr-284, MOD:00047 participates_in GO:0010629 negative regulation of gene expression PMID:20959462 PR:P04637-1 hTP53/iso:1 capable_of GO:0005515 protein binding with PR:O60566 hBUB1B PMID:17671183 capable_of GO:0005515 protein binding with PR:O43683 hBUB1 PMID:19252416 PR:000027833 hTP53/iso:1/Phos:9 Ser-15/Ser-37, MOD:00046 participates_in GO:0010468 regulation of gene expression PMID:14712210 Biological Process GO Term Protein Forms & Complexes Evidence GO:0006915 apoptotic process PR:000035446 hTP53/iso:1/Phos:1 Ser-15, MOD:00046 PMID:11602639 PR:000036624 hTP53/iso:1/Phos:2 Ser-15/Ser-46, MOD:00046 PMID:15642743 GO:0010629 negative regulation of gene expression PR:000027839 hTP53/iso:1/Phos:11 Ser-183/Ser-269, MOD:00046|Thr-284, MOD:00047 PMID:20959462 GO:0043065 positive regulation of apoptotic process PR:000027774 hTP53/iso:1/Ac:1 Lys-120, MOD:00064 PMID:17189187 GO:0045893 positive regulation of transcription, DNA-templated PR:000027808 hTP53/iso:1/Me:3 Lys-372, MOD:00663 PMID:15525938 PR:000027812 hTP53/iso:1/Ac:2 Lys-382, MOD:00064 PMID:20228809 PR:000027814 hTP53/iso:1/Phos:12 Ser-15/Ser-392, MOD:00046 PMID:21317932 GO:0010468 regulation of gene expression PR:000027833 hTP53/iso:1/Phos:9 Ser-15/Ser-37, MOD:00046 PMID:14712210 GO:0045892 negative regulation of transcription, DNA-templated PR:000027810 hTP53/iso:1/Me:4 Lys-370, MOD:00663 PMID:17108971 PR:000027844 p53 complex sumoylated 1 (human) PMID:19339993 Cellular Location GO Term Protein Forms & Complexes Evidence GO:0005634 nucleus PR:000027808 hTP53/iso:1/Me:3 Lys-372, MOD:00663 PMID:15525938 PR:000027814 hTP53/iso:1/Phos:12 Ser-15/Ser-392, MOD:00046 PMID:21317932 PR:000035446 hTP53/iso:1/Phos:1 Ser-15, MOD:00046 PMID:11602639

top