[Term]
id: PR:000027806
name: cellular tumor antigen p53 isoform 1 ubiquitinated 1 (human)
def: "A cellular tumor antigen p53 isoform 1 ubiquitinated 1 in human. UniProtKB:P04637-1, Lys-291/Lys-292, MOD:01148." [PMID:19536131, PRO:PD]
comment: Category=organism-modification. UbLigase=("MKRN1"; PR:Q9UHC7; Lys-291/Lys-292).
synonym: "hTP53/iso:1/Ubiq:1" EXACT PRO-short-label [PRO:DNx]
synonym: "p53-uLys291-uLys292" EXACT [PMID:19536131]
synonym: "UniProtKB:P04637-1, Lys-291/Lys-292, MOD:01148" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000027805 ! cellular tumor antigen p53 isoform 1 ubiquitinated 1
relationship: has_part MOD:01148 ! ubiquitinylated lysine

[Term]
id: PR:000027846
name: cellular tumor antigen p53 isoform 1 unmodified form (human)
def: "A cellular tumor antigen p53 isoform 1 unmodified form in human." [PMID:19339993, PRO:CNA]
comment: Category=organism-modification.
synonym: "hTP53/iso:1/UnMod" EXACT PRO-short-label [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000003037 ! cellular tumor antigen p53 isoform 1 unmodified form

[Term]
id: PR:000027808
name: cellular tumor antigen p53 isoform 1 methylated 3 (human)
def: "A cellular tumor antigen p53 isoform 1 methylated 3 in human. This modification promotes p53 stability and inhibits Smyd2 mediated p53 methylation at Lys-370. UniProtKB:P04637-1, Lys-372, MOD:00663." [PMID:15525938, PRO:PD]
comment: Category=organism-modification. Methylase=("SETD7"; PR:Q8WTS6; Lys-372).
synonym: "p53-mLys372" EXACT []
synonym: "hTP53/iso:1/Me:3" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P04637-1, Lys-372, MOD:00663" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000027807 ! cellular tumor antigen p53 isoform 1 methylated 3
relationship: has_part MOD:00663 ! methylated lysine

[Term]
id: PR:000035446
name: cellular tumor antigen p53 isoform 1 phosphorylated 1 (human)
def: "A cellular tumor antigen p53 isoform 1 phosphorylated 1 in human. Phosphorylated form found upon DNA damage. UniProtKB:P04637-1, Ser-15, MOD:00046." [PMID:22099307, PRO:KER]
comment: Category=organism-modification. Kinase=("ATM"; PR:Q13315).
synonym: "p53S15 (human)" EXACT []
synonym: "hTP53/iso:1/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P04637-1, Ser-15, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000003039 ! cellular tumor antigen p53 isoform 1 phosphorylated 1
relationship: has_part MOD:00046 ! O-phospho-L-serine

[Term]
id: PR:000027841
name: cellular tumor antigen p53 isoform 1 sumoylated 1 (human)
def: "A cellular tumor antigen p53 isoform 1 sumoylated 1 in human. UniProtKB:P04637-1, Lys-386, MOD:01149." [PMID:19339993, PRO:PD]
comment: Category=organism-modification.
synonym: "p53-sLys386" EXACT []
synonym: "hTP53/iso:1/Sumo:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P04637-1, Lys-386, MOD:01149" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000027840 ! cellular tumor antigen p53 isoform 1 sumoylated 1
relationship: has_part MOD:01149 ! sumoylated lysine

[Term]
id: PR:P04637-8
name: cellular tumor antigen p53 isoform h8 (human)
def: "A cellular tumor antigen p53 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P04637-8." [PRO:DNx, UniProtKB:P04637]
comment: Category=organism-sequence.
synonym: "hTP53/iso:h8" EXACT PRO-short-label [PRO:DNx]
synonym: "cellular tumor antigen p53 isoform Del133-p53beta (human)" EXACT [UniProtKB:P04637]
xref: UniProtKB:P04637-8
is_a: PR:P04637 ! cellular tumor antigen p53 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P04637-9
name: cellular tumor antigen p53 isoform h9 (human)
def: "A cellular tumor antigen p53 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P04637-9." [PRO:DNx, UniProtKB:P04637]
comment: Category=organism-sequence.
synonym: "hTP53/iso:h9" EXACT PRO-short-label [PRO:DNx]
synonym: "cellular tumor antigen p53 isoform Del133-p53gamma (human)" EXACT [UniProtKB:P04637]
xref: UniProtKB:P04637-9
is_a: PR:P04637 ! cellular tumor antigen p53 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000049519
name: cellular tumor antigen p53 phosphorylated 16 (human)
def: "A cellular tumor antigen p53 (human) that has been post-translationally modified to include phosphoserine at positions 15, 20 and 46 of the amino acid sequence represented by UniProtKB:P04637. UniProtKB:P04637, Ser-15/Ser-20/Ser-46, MOD:00046." [PRO:DNx, Reactome:R-HSA-6798369]
comment: Category=organism-modification.
synonym: "hTP53/Phos:16" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P04637, Ser-15/Ser-20/Ser-46, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-6798369 "PR:000049519 located_in GO:0005654"
is_a: PR:P04637 ! cellular tumor antigen p53 (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000049518
name: cellular tumor antigen p53 phosphorylated 15 (human)
def: "A cellular tumor antigen p53 (human) that has been post-translationally modified to include phosphoserine at positions 15, 20 and 392 of the amino acid sequence represented by UniProtKB:P04637. UniProtKB:P04637, Ser-15/Ser-20/Ser-392, MOD:00046." [PRO:DNx, Reactome:R-HSA-6805053]
comment: Category=organism-modification.
synonym: "hTP53/Phos:15" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P04637, Ser-15/Ser-20/Ser-392, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-6805053 "PR:000049518 located_in GO:0005654"
is_a: PR:P04637 ! cellular tumor antigen p53 (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P04637-1
name: cellular tumor antigen p53 isoform 1 (human)
def: "A cellular tumor antigen p53 isoform 1 that is encoded in the genome of human." [PMID:17671183, PMID:19252416, PRO:KER]
comment: Category=organism-sequence.
synonym: "hTP53/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P04637-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000003036 ! cellular tumor antigen p53 isoform 1

[Term]
id: PR:000049515
name: cellular tumor antigen p53 phosphorylated 1 (human)
def: "A cellular tumor antigen p53 (human) that has been post-translationally modified to include phosphoserine at position 15 of the amino acid sequence represented by UniProtKB:P04637. UniProtKB:P04637, Ser-15, MOD:00046." [PRO:DNx, Reactome:R-HSA-69507]
comment: Category=organism-modification.
synonym: "hTP53/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P04637, Ser-15, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-69507 "PR:000049515 located_in GO:0005654"
is_a: PR:P04637 ! cellular tumor antigen p53 (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000049514
name: cellular tumor antigen p53 dimethylated 2 (human)
def: "A cellular tumor antigen p53 (human) that has been post-translationally modified to include dimethyl-L-lysine at position 373 of the amino acid sequence represented by UniProtKB:P04637. UniProtKB:P04637, Lys-373, MOD:00084." [PRO:DNx, Reactome:R-HSA-6805759]
comment: Category=organism-modification.
synonym: "hTP53/Me2:2" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P04637, Lys-373, MOD:00084" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-6805759 "PR:000049514 located_in GO:0005654"
is_a: PR:P04637 ! cellular tumor antigen p53 (human)
relationship: has_part MOD:00084 ! N6,N6-dimethyl-L-lysine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000049517
name: cellular tumor antigen p53 phosphorylated 14 (human)
def: "A cellular tumor antigen p53 (human) that has been post-translationally modified to include phosphoserine at positions 15, 20 and 269, and phosphothreonine at position 284 of the amino acid sequence represented by UniProtKB:P04637. UniProtKB:P04637, Ser-15/Ser-20/Ser-269, MOD:00046|Thr-284, MOD:00047." [PRO:DNx, Reactome:R-HSA-6805133]
comment: Category=organism-modification.
synonym: "hTP53/Phos:14" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P04637, Ser-15/Ser-20/Ser-269, MOD:00046|Thr-284, MOD:00047" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-6805133 "PR:000049517 located_in GO:0005654"
is_a: PR:P04637 ! cellular tumor antigen p53 (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: has_part MOD:00047 ! O-phospho-L-threonine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000049516
name: cellular tumor antigen p53 phosphorylated 13 (human)
def: "A cellular tumor antigen p53 (human) that has been post-translationally modified to include phosphoserine at positions 15 and 20 of the amino acid sequence represented by UniProtKB:P04637. UniProtKB:P04637, Ser-15/Ser-20, MOD:00046." [PRO:DNx, Reactome:R-HSA-69683]
comment: Category=organism-modification.
synonym: "hTP53/Phos:13" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P04637, Ser-15/Ser-20, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-69683 "PR:000049516 located_in GO:0005654"
is_a: PR:P04637 ! cellular tumor antigen p53 (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P04637-4
name: cellular tumor antigen p53 isoform h4 (human)
def: "A cellular tumor antigen p53 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P04637-4." [PRO:DNx, UniProtKB:P04637]
comment: Category=organism-sequence.
synonym: "hTP53/iso:h4" EXACT PRO-short-label [PRO:DNx]
synonym: "cellular tumor antigen p53 isoform p47 (human)" EXACT [UniProtKB:P04637]
synonym: "cellular tumor antigen p53 isoform Del40-p53 (human)" EXACT [UniProtKB:P04637]
synonym: "cellular tumor antigen p53 isoform Del40-p53alpha (human)" EXACT [UniProtKB:P04637]
xref: UniProtKB:P04637-4
is_a: PR:P04637 ! cellular tumor antigen p53 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P04637-2
name: cellular tumor antigen p53 isoform h2 (human)
def: "A cellular tumor antigen p53 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P04637-2." [PRO:DNx, UniProtKB:P04637]
comment: Category=organism-sequence.
synonym: "hTP53/iso:h2" EXACT PRO-short-label [PRO:DNx]
synonym: "cellular tumor antigen p53 isoform I9RET (human)" EXACT [UniProtKB:P04637]
synonym: "cellular tumor antigen p53 isoform p53beta (human)" EXACT [UniProtKB:P04637]
xref: UniProtKB:P04637-2
is_a: PR:P04637 ! cellular tumor antigen p53 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000049513
name: cellular tumor antigen p53 dimethylated 3 (human)
def: "A cellular tumor antigen p53 (human) that has been post-translationally modified to include dimethyl-L-lysine at positions 370 and 382 of the amino acid sequence represented by UniProtKB:P04637. UniProtKB:P04637, Lys-370/Lys-382, MOD:00084." [PRO:DNx, Reactome:R-HSA-3222242]
comment: Category=organism-modification.
synonym: "hTP53/Me2:3" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P04637, Lys-370/Lys-382, MOD:00084" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-3222242 "PR:000049513 located_in GO:0005654"
is_a: PR:P04637 ! cellular tumor antigen p53 (human)
relationship: has_part MOD:00084 ! N6,N6-dimethyl-L-lysine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P04637-7
name: cellular tumor antigen p53 isoform h7 (human)
def: "A cellular tumor antigen p53 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P04637-7." [PRO:DNx, UniProtKB:P04637]
comment: Category=organism-sequence.
synonym: "hTP53/iso:h7" EXACT PRO-short-label [PRO:DNx]
synonym: "cellular tumor antigen p53 isoform Del133-p53 (human)" EXACT [UniProtKB:P04637]
synonym: "cellular tumor antigen p53 isoform Del133-p53alpha (human)" EXACT [UniProtKB:P04637]
xref: UniProtKB:P04637-7
is_a: PR:P04637 ! cellular tumor antigen p53 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000027770
name: cellular tumor antigen p53 isoform 1 phosphorylated 5 (human)
def: "A cellular tumor antigen p53 isoform 1 phosphorylated 5 in human. UniProtKB:P04637-1, Ser-15, MOD:00046|Thr-18, MOD:00047." [PMID:10606744, PRO:PD]
comment: Category=organism-modification.
synonym: "p53-pSer15-pThr18" EXACT []
synonym: "hTP53/iso:1/Phos:5" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P04637-1, Ser-15, MOD:00046|Thr-18, MOD:00047" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000027769 ! cellular tumor antigen p53 isoform 1 phosphorylated 5
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: has_part MOD:00047 ! O-phospho-L-threonine

[Term]
id: PR:000027772
name: cellular tumor antigen p53 isoform 1 phosphorylated 6 (human)
def: "A cellular tumor antigen p53 isoform 1 phosphorylated 6 in human. UniProtKB:P04637-1, Ser-269, MOD:00046." [PMID:20851891, PRO:PD]
comment: Category=organism-modification.
synonym: "p53-pSer269" EXACT []
synonym: "hTP53/iso:1/Phos:6" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P04637-1, Ser-269, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000027771 ! cellular tumor antigen p53 isoform 1 phosphorylated 6
relationship: has_part MOD:00046 ! O-phospho-L-serine

[Term]
id: PR:000003035
name: cellular tumor antigen p53
def: "A protein that is a translation product of the human TP53 gene or a 1:1 ortholog thereof." [PRO:CNA]
comment: Category=gene.
synonym: "P53" RELATED Gene-based []
synonym: "TP53" EXACT PRO-short-label [PRO:DNx]
synonym: "Trp53" RELATED Gene-based []
synonym: "antigen NY-CO-13" EXACT []
synonym: "phosphoprotein p53" EXACT []
synonym: "tumor suppressor p53" EXACT []
xref: PIRSF:PIRSF002089
is_a: PR:000000001 ! protein

[Term]
id: PR:P04637-5
name: cellular tumor antigen p53 isoform h5 (human)
def: "A cellular tumor antigen p53 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P04637-5." [PRO:DNx, UniProtKB:P04637]
comment: Category=organism-sequence.
synonym: "hTP53/iso:h5" EXACT PRO-short-label [PRO:DNx]
synonym: "cellular tumor antigen p53 isoform Del40-p53beta (human)" EXACT [UniProtKB:P04637]
xref: UniProtKB:P04637-5
is_a: PR:P04637 ! cellular tumor antigen p53 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P04637-3
name: cellular tumor antigen p53 isoform h3 (human)
def: "A cellular tumor antigen p53 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P04637-3." [PRO:DNx, UniProtKB:P04637]
comment: Category=organism-sequence.
synonym: "hTP53/iso:h3" EXACT PRO-short-label [PRO:DNx]
synonym: "cellular tumor antigen p53 isoform p53gamma (human)" EXACT [UniProtKB:P04637]
xref: UniProtKB:P04637-3
is_a: PR:P04637 ! cellular tumor antigen p53 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P04637-6
name: cellular tumor antigen p53 isoform h6 (human)
def: "A cellular tumor antigen p53 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P04637-6." [PRO:DNx, UniProtKB:P04637]
comment: Category=organism-sequence.
synonym: "hTP53/iso:h6" EXACT PRO-short-label [PRO:DNx]
synonym: "cellular tumor antigen p53 isoform Del40-p53gamma (human)" EXACT [UniProtKB:P04637]
xref: UniProtKB:P04637-6
is_a: PR:P04637 ! cellular tumor antigen p53 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000027839
name: cellular tumor antigen p53 isoform 1 phosphorylated 11 (human)
def: "A cellular tumor antigen p53 isoform 1 phosphorylated 11 in human. UniProtKB:P04637-1, Ser-183/Ser-269, MOD:00046|Thr-284, MOD:00047." [PMID:20959462, PRO:PD]
comment: Category=organism-modification. Kinase=("AURKB"; PR:Q96GD4).
synonym: "hTP53/iso:1/Phos:11" EXACT PRO-short-label [PRO:DNx]
synonym: "p53-pSer183-pSer269-pThr284" EXACT []
synonym: "UniProtKB:P04637-1, Ser-183/Ser-269, MOD:00046|Thr-284, MOD:00047" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000027838 ! cellular tumor antigen p53 isoform 1 phosphorylated 11
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: has_part MOD:00047 ! O-phospho-L-threonine

[Term]
id: PR:000027837
name: cellular tumor antigen p53 isoform 1 phosphorylated 10 (human)
def: "A cellular tumor antigen p53 isoform 1 phosphorylated 10 in human. UniProtKB:P04637-1, Ser-15/Ser-20/Ser-33, MOD:00046." [PMID:10202145, PRO:PD]
comment: Category=organism-modification.
synonym: "hTP53/iso:1/Phos:10" EXACT PRO-short-label [PRO:DNx]
synonym: "p53-pSer15-pSer20-pSer33" EXACT []
synonym: "UniProtKB:P04637-1, Ser-15/Ser-20/Ser-33, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000027836 ! cellular tumor antigen p53 isoform 1 phosphorylated 10
relationship: has_part MOD:00046 ! O-phospho-L-serine

[Term]
id: PR:000027835
name: cellular tumor antigen p53 isoform 1 O-glycosylated 1 (human)
def: "A cellular tumor antigen p53 isoform 1 O-glycosylated 1 in human. UniProtKB:P04637-1, Ser-149, MOD:00805|Thr-155, PR:000026291." [PMID:16964247, PRO:PD]
comment: Category=organism-modification.
synonym: "p53-gSer149" EXACT []
synonym: "hTP53/iso:1/OGlyco:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P04637-1, Ser-149, MOD:00805|Thr-155, PR:000026291" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000027834 ! cellular tumor antigen p53 isoform 1 O-glycosylated 1
relationship: has_part MOD:00805 ! O-(N-acetylamino)glucosyl-L-serine

[Term]
id: PR:000027833
name: cellular tumor antigen p53 isoform 1 phosphorylated 9 (human)
def: "A cellular tumor antigen p53 isoform 1 phosphorylated 9 in human. UniProtKB:P04637-1, Ser-15/Ser-37, MOD:00046." [PMID:14712210, PRO:PD]
comment: Category=organism-modification.
synonym: "p53-pSer15-pSer37" EXACT []
synonym: "hTP53/iso:1/Phos:9" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P04637-1, Ser-15/Ser-37, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000027832 ! cellular tumor antigen p53 isoform 1 phosphorylated 9
relationship: has_part MOD:00046 ! O-phospho-L-serine

[Term]
id: PR:000027831
name: cellular tumor antigen p53 isoform 1 phosphorylated 8 (human)
def: "A cellular tumor antigen p53 isoform 1 phosphorylated 8 in human. UniProtKB:P04637-1, Ser-215/Ser-315, MOD:00046." [PMID:15469940, PRO:PD]
comment: Category=organism-modification. Kinase=("AURKA"; PR:O14965).
synonym: "hTP53/iso:1/Phos:8" EXACT PRO-short-label [PRO:DNx]
synonym: "p53-pSer215-pSer315" EXACT []
synonym: "UniProtKB:P04637-1, Ser-215/Ser-315, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000027830 ! cellular tumor antigen p53 isoform 1 phosphorylated 8
relationship: has_part MOD:00046 ! O-phospho-L-serine

[Term]
id: PR:000027810
name: cellular tumor antigen p53 isoform 1 methylated 4 (human)
def: "A cellular tumor antigen p53 isoform 1 methylated 4 in human. UniProtKB:P04637-1, Lys-370, MOD:00663." [PMID:17108971, PRO:PD]
comment: Category=organism-modification. Methylase=("SMYD2"; PR:Q9NRG4).
synonym: "p53-mLys370" EXACT []
synonym: "hTP53/iso:1/Me:4" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P04637-1, Lys-370, MOD:00663" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000027809 ! cellular tumor antigen p53 isoform 1 methylated 4
relationship: has_part MOD:00663 ! methylated lysine

[Term]
id: PR:000049524
name: cellular tumor antigen p53 phosphorylated 4 (human)
def: "A cellular tumor antigen p53 (human) that has been post-translationally modified to include phosphothreonine at position 55 of the amino acid sequence represented by UniProtKB:P04637. UniProtKB:P04637, Thr-55, MOD:00047." [PRO:DNx, Reactome:R-HSA-6805400]
comment: Category=organism-modification.
synonym: "hTP53/Phos:4" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P04637, Thr-55, MOD:00047" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-6805400 "PR:000049524 located_in GO:0005654"
is_a: PR:P04637 ! cellular tumor antigen p53 (human)
relationship: has_part MOD:00047 ! O-phospho-L-threonine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000027812
name: cellular tumor antigen p53 isoform 1 acetylated 2 (human)
def: "A cellular tumor antigen p53 isoform 1 acetylated 2 in human. UniProtKB:P04637-1, Lys-382, MOD:00064." [PMID:20228809, PRO:PD]
comment: Category=organism-modification. Acetylase=("EP300"; PR:Q09472; Lys-382).
synonym: "p53-acLys382" EXACT []
synonym: "hTP53/iso:1/Ac:2" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P04637-1, Lys-382, MOD:00064" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000027811 ! cellular tumor antigen p53 isoform 1 acetylated 2
relationship: has_part MOD:00064 ! N6-acetyl-L-lysine

[Term]
id: PR:000027814
name: cellular tumor antigen p53 isoform 1 phosphorylated 12 (human)
def: "A cellular tumor antigen p53 isoform 1 phosphorylated 12 in human. UniProtKB:P04637-1, Ser-15/Ser-392, MOD:00046." [PMID:21317932, PRO:PD]
comment: Category=organism-modification. Kinase=("NUAK1"; PR:O60285; Ser-15/Ser-392).
synonym: "p53-pSer15-pSer392" EXACT []
synonym: "hTP53/iso:1/Phos:12" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P04637-1, Ser-15/Ser-392, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000027813 ! cellular tumor antigen p53 isoform 1 phosphorylated 12
relationship: has_part MOD:00046 ! O-phospho-L-serine

[Term]
id: PR:000049526
name: cellular tumor antigen p53 ubiquitinated form (human)
def: "A cellular tumor antigen p53 (human) that includes at least one ubiquitinated lysine. UniProtKB:P04637, MOD:01148." [PRO:DNx, Reactome:R-HSA-6793681]
comment: Category=organism-modification.
synonym: "hTP53/UbiqLys+" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P04637, MOD:01148" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-6793681 "PR:000049526 located_in GO:0005829"
intersection_of: has_part MOD:01148 ! ubiquitinylated lysine
intersection_of: PR:P04637 ! cellular tumor antigen p53 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P04637
name: cellular tumor antigen p53 (human)
def: "A cellular tumor antigen p53 that is encoded in the genome of human." [PRO:CNA, UniProtKB:P04637]
comment: Category=organism-gene.
synonym: "P53" RELATED Gene-based [UniProtKB:P04637]
synonym: "TP53" RELATED Gene-based [UniProtKB:P04637]
synonym: "hTP53" EXACT PRO-short-label [PRO:DNx]
synonym: "antigen NY-CO-13 (human)" EXACT [UniProtKB:P04637]
synonym: "phosphoprotein p53 (human)" EXACT [UniProtKB:P04637]
synonym: "tumor suppressor p53 (human)" EXACT [UniProtKB:P04637]
xref: Reactome:R-HSA-69488 "PR:P04637 located_in GO:0005654"
xref: Reactome:R-HSA-6813797 "PR:P04637 located_in GO:0005829"
xref: Reactome:R-HSA-8869337 "PR:P04637 located_in GO:0005829"
xref: UniProtKB:P04637
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000003035 ! cellular tumor antigen p53
relationship: has_gene_template HGNC:11998 ! TP53 (human)

[Term]
id: PR:000036624
name: cellular tumor antigen p53 isoform 1 phosphorylated 2 (human)
def: "A cellular tumor antigen p53 isoform 1 phosphorylated 2 in human. UniProtKB:P04637-1, Ser-15/Ser-46, MOD:00046." [PMID:15642743, PRO:CL]
comment: Category=organism-modification.
synonym: "hTP53/iso:1/Phos:2" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P04637-1, Ser-15/Ser-46, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000003040 ! cellular tumor antigen p53 isoform 1 phosphorylated 2
relationship: has_part MOD:00046 ! O-phospho-L-serine

[Term]
id: PR:000027774
name: cellular tumor antigen p53 isoform 1 acetylated 1 (human)
def: "A cellular tumor antigen p53 isoform 1 acetylated 1 in human. UniProtKB:P04637-1, Lys-120, MOD:00064." [PMID:17189187, PRO:PD]
comment: Category=organism-modification. Acetylase=("MYST1"; PR:Q9H7Z6).
synonym: "p53-acLys120" EXACT []
synonym: "hTP53/iso:1/Ac:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P04637-1, Lys-120, MOD:00064" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000027773 ! cellular tumor antigen p53 isoform 1 acetylated 1
relationship: has_part MOD:00064 ! N6-acetyl-L-lysine

[Term]
id: PR:000027766
name: cellular tumor antigen p53 isoform 1 dimethylated 1 (human)
def: "A cellular tumor antigen p53 isoform 1 dimethylated 1 in human. UniProtKB:P04637-1, Lys-382, MOD:00084." [PMID:18840612, PRO:PD]
comment: Category=organism-modification.
synonym: "p53K382me2" EXACT []
synonym: "hTP53/iso:1/Me2:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P04637-1, Lys-382, MOD:00084" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000027765 ! cellular tumor antigen p53 isoform 1 dimethylated 1
relationship: has_part MOD:00084 ! N6,N6-dimethyl-L-lysine

[Term]
id: PR:000049525
name: cellular tumor antigen p53 sumoylated 1 (human)
def: "A cellular tumor antigen p53 (human) that has been post-translationally modified to include sumoylated lysine at position 386 of the amino acid sequence represented by UniProtKB:P04637. UniProtKB:P04637, Lys-386, MOD:01149." [PRO:DNx, Reactome:R-HSA-2997661]
comment: Category=organism-modification.
synonym: "hTP53/Sumo:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P04637, Lys-386, MOD:01149" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-2997661 "PR:000049525 located_in GO:0005654"
is_a: PR:P04637 ! cellular tumor antigen p53 (human)
relationship: has_part MOD:01149 ! sumoylated lysine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000027764
name: cellular tumor antigen p53 isoform 1 phosphorylated 3 (human)
def: "A cellular tumor antigen p53 isoform 1 phosphorylated 3 in human. UniProtKB:P04637-1, Thr-81, MOD:00047." [PMID:11283254, PRO:PD]
comment: Category=organism-modification. Kinase=("JNK").
synonym: "p53alpha pT81" EXACT []
synonym: "hTP53/iso:1/Phos:3" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P04637-1, Thr-81, MOD:00047" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000027763 ! cellular tumor antigen p53 isoform 1 phosphorylated 3
relationship: has_part MOD:00047 ! O-phospho-L-threonine

[Term]
id: PR:000049520
name: cellular tumor antigen p53 phosphorylated 17 (human)
def: "A cellular tumor antigen p53 (human) that has been post-translationally modified to include phosphoserine at positions 15, 33 and 46 of the amino acid sequence represented by UniProtKB:P04637. UniProtKB:P04637, Ser-15/Ser-33/Ser-46, MOD:00046." [PRO:DNx, Reactome:R-HSA-6805268]
comment: Category=organism-modification.
synonym: "hTP53/Phos:17" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P04637, Ser-15/Ser-33/Ser-46, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-6805268 "PR:000049520 located_in GO:0005654"
is_a: PR:P04637 ! cellular tumor antigen p53 (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000049521
name: cellular tumor antigen p53 phosphorylated 12 (human)
def: "A cellular tumor antigen p53 (human) that has been post-translationally modified to include phosphoserine at positions 15 and 392 of the amino acid sequence represented by UniProtKB:P04637. UniProtKB:P04637, Ser-15/Ser-392, MOD:00046." [PRO:DNx, Reactome:R-HSA-3222015]
comment: Category=organism-modification.
synonym: "hTP53/Phos:12" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P04637, Ser-15/Ser-392, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-3222015 "PR:000049521 located_in GO:0005654"
is_a: PR:P04637 ! cellular tumor antigen p53 (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000049522
name: cellular tumor antigen p53 phosphorylated 18 (human)
def: "A cellular tumor antigen p53 (human) that has been post-translationally modified to include phosphoserine at position 315 of the amino acid sequence represented by UniProtKB:P04637. UniProtKB:P04637, Ser-315, MOD:00046." [PRO:DNx, Reactome:R-HSA-6805106]
comment: Category=organism-modification.
synonym: "hTP53/Phos:18" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P04637, Ser-315, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-6805106 "PR:000049522 located_in GO:0005654"
is_a: PR:P04637 ! cellular tumor antigen p53 (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000049523
name: cellular tumor antigen p53 phosphorylated 19 (human)
def: "A cellular tumor antigen p53 (human) that has been post-translationally modified to include phosphoserine at position 37 of the amino acid sequence represented by UniProtKB:P04637. UniProtKB:P04637, Ser-37, MOD:00046." [PRO:DNx, Reactome:R-HSA-3239022]
comment: Category=organism-modification.
synonym: "hTP53/Phos:19" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P04637, Ser-37, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-3239022 "PR:000049523 located_in GO:0005654"
is_a: PR:P04637 ! cellular tumor antigen p53 (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000027768
name: cellular tumor antigen p53 isoform 1 phosphorylated 4 (human)
def: "A cellular tumor antigen p53 isoform 1 phosphorylated 4 in human. UniProtKB:P04637-1, Thr-55, MOD:00047." [PMID:15053879, PRO:PD]
comment: Category=organism-modification. Kinase=("TAF1"; PR:P21675; Thr-55).
synonym: "p53-pThr55" EXACT []
synonym: "hTP53/iso:1/Phos:4" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P04637-1, Thr-55, MOD:00047" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000027767 ! cellular tumor antigen p53 isoform 1 phosphorylated 4
relationship: has_part MOD:00047 ! O-phospho-L-threonine

[Term]
id: PR:000027829
name: cellular tumor antigen p53 isoform 1 phosphorylated 7 (human)
def: "A cellular tumor antigen p53 isoform 1 phosphorylated 7 in human. UniProtKB:P04637-1, Ser-33/Ser-315/Ser-392, MOD:00046." [PMID:16552184, PRO:PD]
comment: Category=organism-modification. Kinase=("CDK9"; PR:P50750).
synonym: "hTP53/iso:1/Phos:7" EXACT PRO-short-label [PRO:DNx]
synonym: "p53-pSer33-pSer315-pSer392" EXACT []
synonym: "UniProtKB:P04637-1, Ser-33/Ser-315/Ser-392, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000027828 ! cellular tumor antigen p53 isoform 1 phosphorylated 7
relationship: has_part MOD:00046 ! O-phospho-L-serine

[Term]
id: PR:000027827
name: cellular tumor antigen p53 isoform 1 dimethylated 2 (human)
def: "A cellular tumor antigen p53 isoform 1 dimethylated 2 in human. UniProtKB:P04637-1, Lys-373, MOD:00084." [PMID:20118233, PRO:PD]
comment: Category=organism-modification. Methylase=("EHMT1"; PR:Q9H9B1; Lys-373). Methylase=("EHMT2"; PR:Q96KQ7; Lys-373).
synonym: "p53-me2Lys373" EXACT []
synonym: "hTP53/iso:1/Me2:2" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P04637-1, Lys-373, MOD:00084" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000027826 ! cellular tumor antigen p53 isoform 1 dimethylated 2
relationship: has_part MOD:00084 ! N6,N6-dimethyl-L-lysine