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Protein Ontology Report - TP53

PR:000003035 - http://purl.obolibrary.org/obo/PR_000003035
Ontology Information
PRO ID PR:000003035 Show OBO stanza / PAF
PRO name cellular tumor antigen p53
Synonyms
PRO-short-label: TP53
EXACT: antigen NY-CO-13; phosphoprotein p53; tumor suppressor p53
Gene-based: P53; Trp53
Definition A protein that is a translation product of the human TP53 gene or a 1:1 ortholog thereof. [PRO:CNA]
PRO Category gene
Parent PR:000000001 protein
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Independent Organism-Specific
Category Number of Terms Category Number of Terms
gene 1 organism-gene 5
sequence 1 organism-sequence 9
modification 23 organism-modification 38
union 0
Term Hierarchy Visualization DAG     OLS     Cytoscape


Interactive Sequence View Select/align proteoforms across species

Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

TP53 forms found in complexes
TP53 Component Complexes
PR:000027841 hTP53/iso:1/Sumo:1 PR:000027844 p53 complex sumoylated 1 (human)
PR:000027846 hTP53/iso:1/UnMod PR:000027844 p53 complex sumoylated 1 (human)

Functional Annotation
PRO Term GO Annotation Evidence
PR:000027766
hTP53/iso:1/Me2:1
Lys-382, MOD:00084 		capable_of GO:0005515 protein binding with PR:Q12888 hTP53BP1 PMID:18840612
PR:000027810
hTP53/iso:1/Me:4
Lys-370, MOD:00663 		participates_in GO:0045892 negative regulation of transcription, DNA-templated PMID:17108971
PR:000027812
hTP53/iso:1/Ac:2
Lys-382, MOD:00064 		participates_in GO:0045893 positive regulation of transcription, DNA-templated PMID:20228809
PR:000027808
hTP53/iso:1/Me:3
Lys-372, MOD:00663 		located_in GO:0005634 nucleus PMID:15525938
participates_in GO:0045893 positive regulation of transcription, DNA-templated PMID:15525938
PR:000027814
hTP53/iso:1/Phos:12
Ser-15/Ser-392, MOD:00046 		located_in GO:0005634 nucleus PMID:21317932
participates_in GO:0045893 positive regulation of transcription, DNA-templated PMID:21317932
PR:000027774
hTP53/iso:1/Ac:1
Lys-120, MOD:00064 		participates_in GO:0043065 positive regulation of apoptotic process PMID:17189187
PR:000027844
p53 complex sumoylated 1 (human)
capable_of NOT GO:0003677 DNA binding PMID:19339993
participates_in GO:0045892 negative regulation of transcription, DNA-templated PMID:19339993
PR:000035446
hTP53/iso:1/Phos:1
Ser-15, MOD:00046 		located_in GO:0005634 nucleus PMID:11602639
participates_in GO:0006915 apoptotic process PMID:11602639
PR:000036624
hTP53/iso:1/Phos:2
Ser-15/Ser-46, MOD:00046 		capable_of GO:0005515 protein binding with PR:000003109 MAPK14/Phos:1 PMID:15642743
participates_in GO:0006915 apoptotic process PMID:15642743
PR:000027839
hTP53/iso:1/Phos:11
Ser-183/Ser-269, MOD:00046|Thr-284, MOD:00047 		participates_in GO:0010629 negative regulation of gene expression PMID:20959462
PR:P04637-1
hTP53/iso:1
capable_of GO:0005515 protein binding with PR:O60566 hBUB1B PMID:17671183
capable_of GO:0005515 protein binding with PR:O43683 hBUB1 PMID:19252416
PR:000027833
hTP53/iso:1/Phos:9
Ser-15/Ser-37, MOD:00046 		participates_in GO:0010468 regulation of gene expression PMID:14712210
Biological Process GO Term Protein Forms & Complexes Evidence
GO:0006915 apoptotic process PR:000035446 hTP53/iso:1/Phos:1
Ser-15, MOD:00046
PMID:11602639
PR:000036624 hTP53/iso:1/Phos:2
Ser-15/Ser-46, MOD:00046
PMID:15642743
GO:0010629 negative regulation of gene expression PR:000027839 hTP53/iso:1/Phos:11
Ser-183/Ser-269, MOD:00046|Thr-284, MOD:00047
PMID:20959462
GO:0043065 positive regulation of apoptotic process PR:000027774 hTP53/iso:1/Ac:1
Lys-120, MOD:00064
PMID:17189187
GO:0045893 positive regulation of transcription, DNA-templated PR:000027808 hTP53/iso:1/Me:3
Lys-372, MOD:00663
PMID:15525938
PR:000027812 hTP53/iso:1/Ac:2
Lys-382, MOD:00064
PMID:20228809
PR:000027814 hTP53/iso:1/Phos:12
Ser-15/Ser-392, MOD:00046
PMID:21317932
GO:0010468 regulation of gene expression PR:000027833 hTP53/iso:1/Phos:9
Ser-15/Ser-37, MOD:00046
PMID:14712210
GO:0045892 negative regulation of transcription, DNA-templated PR:000027810 hTP53/iso:1/Me:4
Lys-370, MOD:00663
PMID:17108971
PR:000027844 p53 complex sumoylated 1 (human)

PMID:19339993
Cellular Location GO Term Protein Forms & Complexes Evidence
GO:0005634 nucleus PR:000027808 hTP53/iso:1/Me:3
Lys-372, MOD:00663
PMID:15525938
PR:000027814 hTP53/iso:1/Phos:12
Ser-15/Ser-392, MOD:00046
PMID:21317932
PR:000035446 hTP53/iso:1/Phos:1
Ser-15, MOD:00046
PMID:11602639

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