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Protein Ontology Report - AKT1

PR:000002190 - http://purl.obolibrary.org/obo/PR_000002190
Ontology Information
PRO ID PR:000002190 Show OBO stanza / PAF
PRO name RAC-alpha serine/threonine-protein kinase
Synonyms
PRO-short-label: AKT1
EXACT: AKT1 kinase; PKB alpha; RAC-PK-alpha; protein kinase B; protein kinase B alpha; proto-oncogene c-Akt; thymoma viral proto-oncogene
Gene-based: Akt; PKB; RAC
Definition An AKT kinase that is a translation product of the human AKT1 gene or a 1:1 ortholog thereof. [PRO:WCB]
PRO Category gene
Parent PR:000029189 AKT kinase
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Independent Organism-Specific
Category Number of Terms Category Number of Terms
gene 1 organism-gene 3
sequence 1 organism-sequence 3
modification 5 organism-modification 8
union 0
Term Hierarchy Visualization DAG     OLS     Cytoscape


Interactive Sequence View Select/align proteoforms across species

Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

Functional Annotation
PRO Term GO Annotation Evidence
PR:000002190
AKT1
has_part Pfam:PF00069 Protein kinase domain
has_part Pfam:PF00787 PX domain
has_part Pfam:PF00433 Protein kinase C terminal domain
has_part Pfam:PF00169 PH domain
PR:000028994
hAKT1/iso:1/Phos:1
Thr-308, MOD:00047|Ser-473, MOD:00046 		capable_of GO:0004672 protein kinase activity PMID:8978681
capable_of GO:0005515 protein binding with PR:P41279-1 hMAP3K8/iso:1 PMID:12138205
capable_of GO:0005515 protein binding with PR:O14746-1 hTERT/iso:1 PMID:12586360
capable_of GO:0004674 protein serine/threonine kinase activity PMID:12138205
participates_in GO:0051092 positive regulation of NF-kappaB transcription factor activity PMID:12138205
participates_in GO:0032869 cellular response to insulin stimulus PMID:8978681
PR:000027473
hAKT1/iso:1/Phos:2
Thr-72/Thr-308, MOD:00047|Ser-246/Ser-473, MOD:00046 		participates_in GO:0043066 negative regulation of apoptotic process PMID:16549426
Biological Process GO Term Protein Forms & Complexes Evidence
GO:0043066 negative regulation of apoptotic process PR:000027473 hAKT1/iso:1/Phos:2
Thr-72/Thr-308, MOD:00047|Ser-246/Ser-473, MOD:00046
PMID:16549426
GO:0051092 positive regulation of NF-kappaB transcription factor activity PR:000028994 hAKT1/iso:1/Phos:1
Thr-308, MOD:00047|Ser-473, MOD:00046
PMID:12138205
GO:0032869 cellular response to insulin stimulus PR:000028994 hAKT1/iso:1/Phos:1
Thr-308, MOD:00047|Ser-473, MOD:00046
PMID:8978681

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