| PRO ID |
PR:000000678
Show OBO stanza
/ PAF
|
| PRO name |
sodium leak channel NALCN |
| Synonyms |
| PRO-short-label: |
NALCN |
| EXACT: |
CanIon; sodium leak channel non-selective protein; voltage gated channel-like protein 1 |
| Gene-based: |
VGCNL1 |
|
| Definition |
An ion channel protein that is a translation product of the human NALCN gene or a 1:1 ortholog thereof. The prototype subunit contains four copies of the six transmembrane ion transport protein domain, but the number of copies of this domain varies among splice variants. Responsible for the background sodium ion leak current in neurons and controls neuronal excitability. They are subunits of a voltage-independent, nonselective cation channel.
[PMID:17448995, PRO:CNA]
|
| Comment |
Note: NALCN operates as part of a complex with UNC80 (PR:000017098) and UNC79 (PR:000030850) that together form a fucntional channel. [PRO:DAN, PMID:21040849] |
| PRO Category |
gene |
| Parent |
PR:000049983 ion channel protein |
| Terms by PRO Category |
Retrieve All terms OBO Stanza
/ PAF
| Organism-Independent |
Organism-Specific |
| Category |
Number of Terms |
Category |
Number of Terms |
|
gene
|
1 |
organism-gene
|
3 |
|
sequence
|
3 |
organism-sequence
|
5 |
|
modification
|
0 |
organism-modification
|
0 |
|
union
|
0 |
|
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