[Term]
id: PR:Q8BXR5-2
name: sodium leak channel NALCN isoform 2 (mouse)
def: "A sodium leak channel NALCN isoform 3 that is encoded in the genome of mouse." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "mNALCN/iso:2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q8BXR5-2
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000000717 ! sodium leak channel NALCN isoform 3

[Term]
id: PR:Q8BXR5
name: sodium leak channel NALCN (mouse)
def: "A sodium leak channel NALCN that is encoded in the genome of mouse." [OMA:Q8BXR5, PRO:DNx]
comment: Category=organism-gene.
synonym: "Nalcn" RELATED Gene-based [UniProtKB:Q8BXR5]
synonym: "Vgcnl1" RELATED Gene-based [UniProtKB:Q8BXR5]
synonym: "mNALCN" EXACT PRO-short-label [PRO:DNx]
synonym: "voltage gated channel-like protein 1 (mouse)" EXACT [UniProtKB:Q8BXR5]
synonym: "sodium leak channel non-selective protein (mouse)" EXACT [UniProtKB:Q8BXR5]
xref: UniProtKB:Q8BXR5
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000000678 ! sodium leak channel NALCN
relationship: has_gene_template MGI:2444306 ! Nalcn (mouse)

[Term]
id: PR:000000678
name: sodium leak channel NALCN
def: "An ion channel protein that is a translation product of the human NALCN gene or a 1:1 ortholog thereof. The prototype subunit contains four copies of the six transmembrane ion transport protein domain, but the number of copies of this domain varies among splice variants. Responsible for the background sodium ion leak current in neurons and controls neuronal excitability. They are subunits of a voltage-independent, nonselective cation channel." [PMID:17448995, PRO:CNA]
comment: Category=gene. Note: NALCN operates as part of a complex with UNC80 (PR:000017098) and UNC79 (PR:000030850) that together form a fucntional channel. [PRO:DAN, PMID:21040849]
synonym: "NALCN" EXACT PRO-short-label [PRO:DNx]
synonym: "CanIon" EXACT []
synonym: "VGCNL1" RELATED Gene-based []
synonym: "voltage gated channel-like protein 1" EXACT []
synonym: "sodium leak channel non-selective protein" EXACT []
xref: IUPHARobj:750
xref: PIRSF:PIRSF038547
is_a: PR:000049983 ! ion channel protein

[Term]
id: PR:Q8IZF0
name: sodium leak channel NALCN (human)
def: "A sodium leak channel NALCN that is encoded in the genome of human." [PRO:CNA, UniProtKB:Q8IZF0]
comment: Category=organism-gene.
synonym: "NALCN" RELATED Gene-based [UniProtKB:Q8IZF0]
synonym: "VGCNL1" RELATED Gene-based [UniProtKB:Q8IZF0]
synonym: "hNALCN" EXACT PRO-short-label [PRO:DNx]
synonym: "CanIon (human)" EXACT [UniProtKB:Q8IZF0]
synonym: "voltage gated channel-like protein 1 (human)" EXACT [UniProtKB:Q8IZF0]
synonym: "sodium leak channel non-selective protein (human)" EXACT [UniProtKB:Q8IZF0]
xref: UniProtKB:Q8IZF0
xref: Reactome:R-HSA-2730661 "PR:Q8IZF0 located_in GO:0005886"
xref: DTO:01100254
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000678 ! sodium leak channel NALCN
relationship: has_gene_template HGNC:19082 ! NALCN (human)

[Term]
id: PR:Q6Q760
name: sodium leak channel NALCN (rat)
def: "A sodium leak channel NALCN that is encoded in the genome of rat." [OMA:Q6Q760, PANTHER:PTHR10037:SF60, PRO:DNx]
comment: Category=organism-gene.
synonym: "Nca" RELATED Gene-based [UniProtKB:Q6Q760]
synonym: "Rb21" RELATED Gene-based [UniProtKB:Q6Q760]
synonym: "Nalcn" RELATED Gene-based [UniProtKB:Q6Q760]
synonym: "Vgcnl1" RELATED Gene-based [UniProtKB:Q6Q760]
synonym: "rNALCN" EXACT PRO-short-label [PRO:DNx]
synonym: "Rb21-channel (rat)" EXACT [UniProtKB:Q6Q760]
synonym: "voltage gated channel-like protein 1 (rat)" EXACT [UniProtKB:Q6Q760]
synonym: "sodium leak channel non-selective protein (rat)" EXACT [UniProtKB:Q6Q760]
synonym: "four domain-type voltage-gated ion channel alpha-1 subunit (rat)" EXACT [UniProtKB:Q6Q760]
xref: UniProtKB:Q6Q760
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000000678 ! sodium leak channel NALCN
relationship: has_gene_template RGD:628710 ! Nalcn (rat)

[Term]
id: PR:000000715
name: sodium leak channel NALCN isoform 1
def: "A sodium leak channel NALCN that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8IZF0-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]
comment: Category=sequence.
synonym: "NALCN/iso:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000000678 ! sodium leak channel NALCN

[Term]
id: PR:000000716
name: sodium leak channel NALCN isoform 2
def: "A sodium leak channel NALCN that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8IZF0-2 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]
comment: Category=sequence.
synonym: "NALCN/iso:2" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000000678 ! sodium leak channel NALCN

[Term]
id: PR:000000717
name: sodium leak channel NALCN isoform 3
def: "A sodium leak channel NALCN that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8IZF0-3 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]
comment: Category=sequence.
synonym: "NALCN/iso:3" EXACT PRO-short-label [PRO:DNx]
synonym: "sodium leak channel non-selective protein isoform 4" EXACT []
is_a: PR:000000678 ! sodium leak channel NALCN

[Term]
id: PR:Q8IZF0-1
name: sodium leak channel NALCN isoform 1 (human)
def: "A sodium leak channel NALCN isoform 1 that is encoded in the genome of human." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "hNALCN/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q8IZF0-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000715 ! sodium leak channel NALCN isoform 1

[Term]
id: PR:Q8IZF0-2
name: sodium leak channel NALCN isoform 2 (human)
def: "A sodium leak channel NALCN isoform 2 that is encoded in the genome of human." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "hNALCN/iso:2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q8IZF0-2
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000716 ! sodium leak channel NALCN isoform 2

[Term]
id: PR:Q8IZF0-3
name: sodium leak channel NALCN isoform 3 (human)
def: "A sodium leak channel NALCN isoform 3 that is encoded in the genome of human." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "hNALCN/iso:3" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q8IZF0-3
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000717 ! sodium leak channel NALCN isoform 3

[Term]
id: PR:Q8BXR5-1
name: sodium leak channel NALCN isoform 1 (mouse)
def: "A sodium leak channel NALCN isoform 1 that is encoded in the genome of mouse." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "mNALCN/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q8BXR5-1
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000000715 ! sodium leak channel NALCN isoform 1