iPTMnet Report for Q9Z2B5 (Eif2ak3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9Z2B5 / E2AK3_MOUSE
Protein Name Eukaryotic translation initiation factor 2-alpha kinase 3 precursor
Gene Name Name: Eif2ak3
Synonyms:Pek,Perk;
Organism Mus musculus (Mouse)

PRO ID PR:Q9Z2B5
DAG View
PRO Name eukaryotic translation initiation factor 2-alpha kinase 3 (mouse)
Definition A eukaryotic translation initiation factor 2-alpha kinase 3 that is encoded in the genome of mouse.
Short Label mEIF2AK3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9Z2B5 (Eif2ak3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S489 Phosphorylation PhosphoSitePlus
T490 Phosphorylation PhosphoSitePlus
T493 Phosphorylation PhosphoSitePlus
S551 Phosphorylation PhosphoSitePlus
Y561 Phosphorylation PhosphoSitePlus   RLIMS-P 24371088
Y615 Phosphorylation PhosphoSitePlus   RLIMS-P 22509299
S711 Phosphorylation PhosphoSitePlus
S715 Phosphorylation PhosphoSitePlus   RLIMS-P 32029570
S717 Phosphorylation RLIMS-P 32029570
S719 Phosphorylation RLIMS-P 32029570
T799 Phosphorylation PhosphoSitePlus   RLIMS-P 32788341
T869 Phosphorylation PhosphoSitePlus
S877 Phosphorylation PhosphoSitePlus
T980 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 22509299, 32811828, 32029570, ...29449538, 32180905, 24371088, 21543844
S1090 Phosphorylation PhosphoSitePlus
S1092 Phosphorylation PhosphoSitePlus
S1094 Phosphorylation PhosphoSitePlus
S1105 Phosphorylation PhosphoSitePlus
Y1108 Phosphorylation PhosphoSitePlus


Q9Z2B5 (Eif2ak3) as PTM Enzyme



Substrate Site Score Source PMID
Q6ZWX6 (Eif2s1) S52 PhosphoSitePlus 17325203, 12370288


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q9Z2B5 (Eif2ak3) Y561 Q99M51 (Nck1) unknown eFIP 24371088
Phosphorylation Q9Z2B5 (Eif2ak3) T799 Q8BJW6 (Eif2a) decreased_association eFIP 32788341