iPTMnet Report for Q9Y6X9 (MORC2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9Y6X9 / MORC2_HUMAN
Protein Name ATPase MORC2
Gene Name Name: MORC2
Synonyms:KIAA0852,ZCWCC1;
Organism Homo sapiens (Human)

PRO ID PR:Q9Y6X9
DAG View
PRO Name ATPase MORC2 (human)
Definition An ATPase MORC2 that is encoded in the genome of human.
Short Label hMORC2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9Y6X9 (MORC2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 22814378, 22223895
S8 Phosphorylation PhosphoSitePlus
T91 Phosphorylation PhosphoSitePlus
Y100 Phosphorylation PhosphoSitePlus
K105 Ubiquitination PhosphoSitePlus
K113 Ubiquitination PhosphoSitePlus
S268 Phosphorylation PhosphoSitePlus
K434 Ubiquitination PhosphoSitePlus
T556 O-Glycosylation GlyGen   PhosphoSitePlus 30379171, 28510447, 34974534
K574 Ubiquitination PhosphoSitePlus
K580 Ubiquitination PhosphoSitePlus
T582 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 23186163, 32401166
S602 Phosphorylation PhosphoSitePlus   UniProt 23186163
T603 Phosphorylation PhosphoSitePlus
S615 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...18220336, 15302935, 18669648, 24275569, 20068231, 16964243
S631 O-Glycosylation GlyGen 30379171, 28510447, 34974534
S631 Phosphorylation PhosphoSitePlus
T634 Phosphorylation PhosphoSitePlus
S648 Phosphorylation PhosphoSitePlus
S649 Phosphorylation PhosphoSitePlus
T650 Phosphorylation PhosphoSitePlus
K683 Methylation PhosphoSitePlus
T684 Phosphorylation PhosphoSitePlus
S686 Phosphorylation PhosphoSitePlus
S696 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S698 Phosphorylation PhosphoSitePlus
S703 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S705 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S711 Phosphorylation PhosphoSitePlus
K713 Acetylation PhosphoSitePlus
T717 O-Glycosylation GlyGen 30379171, 28510447, 34974534
T717 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T723 Phosphorylation PhosphoSitePlus
S725 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 17081983, ...18220336
S730 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 17081983, ...18220336
T733 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S735 Phosphorylation phospho.ELM   PhosphoSitePlus 18220336
S739 Phosphorylation Q13153 (PAK1) phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 21406692, 23186163, 23260667, ...25888627, 18669648, 19690332
S743 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 15302935, ...18669648, 19690332, 20068231
K767 Acetylation PhosphoSitePlus
K767 Sumoylation PhosphoSitePlus
S773 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S777 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...18669648, 20068231
S779 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...18669648, 20068231
S785 Phosphorylation PhosphoSitePlus
T813 Phosphorylation PhosphoSitePlus
K819 Acetylation PhosphoSitePlus
K827 Ubiquitination PhosphoSitePlus
T835 Phosphorylation PhosphoSitePlus
T836 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S856 Phosphorylation PhosphoSitePlus
S861 Phosphorylation PhosphoSitePlus
T864 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
K932 Ubiquitination PhosphoSitePlus
S967 Phosphorylation PhosphoSitePlus
S971 Phosphorylation PhosphoSitePlus
K974 Ubiquitination PhosphoSitePlus
T1016 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S553 Phosphorylation HPRD 20058876, 19664994, 15302935, ...19664995, 18452278, 19651622, 18669648, 16565220, 20068231, 20068230
S634 Phosphorylation HPRD 18669648, 20068231
S641 Phosphorylation HPRD 18669648
S643 Phosphorylation HPRD 18669648
T655 Phosphorylation HPRD 18669648, 20068231
T661 Phosphorylation HPRD 17081983, 20068231
S663 Phosphorylation HPRD 18669648, 17081983, 20068231, ...18452278
S668 Phosphorylation HPRD 18669648, 17081983, 20068231
T671 Phosphorylation HPRD 18669648, 20068231
S677 Phosphorylation HPRD 19651622, 18669648, 17081983, ...18452278
S681 Phosphorylation HPRD 19413330, 18767875, 19664994, ...18452278, 19651622, 15302935, 18669648, 19415658, 20068231
S711 Phosphorylation HPRD 18669648
S715 Phosphorylation HPRD 17081983, 18452278, 19651622, ...18669648, 19415658, 20068231
S717 Phosphorylation HPRD 17081983, 18767875, 18452278, ...19651622, 18669648, 19415658, 20068231
T774 Phosphorylation HPRD 18669648
S794 Phosphorylation HPRD 18452278
T802 Phosphorylation HPRD 18669648
S873 Phosphorylation HPRD 20068231
Y888 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T556 M556 Biomuta [ cosmic ] DOID:363 / uterine cancer [ cosmic, icgc ]
K580 E580 Biomuta DOID:363 / uterine cancer [ cosmic ]
S602 F602 Biomuta DOID:4159 / skin cancer [ cosmic, icgc, tcga ]
S681 F681 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K683 R683 Biomuta DOID:3571 / liver cancer [ cosmic ]
K713 R713 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S743 F743 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K819 N819 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T835 R835 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S861 I861 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S971 F971 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]