iPTMnet Report for Q9Y6X2 (PIAS3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9Y6X2 / PIAS3_HUMAN
Protein Name E3 SUMO-protein ligase PIAS3
Gene Name Name: PIAS3
Organism Homo sapiens (Human)

PRO ID PR:Q9Y6X2
DAG View
PRO Name E3 SUMO-protein ligase PIAS3 (human)
Definition An E3 SUMO-protein ligase PIAS3 that is encoded in the genome of human.
Short Label hPIAS3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9Y6X2 (PIAS3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K8 Ubiquitination PhosphoSitePlus
K34 Ubiquitination PhosphoSitePlus
K46 Sumoylation PhosphoSitePlus
K56 Sumoylation PhosphoSitePlus
K58 Sumoylation PhosphoSitePlus
K58 Ubiquitination PhosphoSitePlus
K183 Ubiquitination PhosphoSitePlus
K230 Sumoylation PhosphoSitePlus
K288 Sumoylation PhosphoSitePlus
K288 Ubiquitination PhosphoSitePlus
S300 Phosphorylation PhosphoSitePlus
K305 Ubiquitination PhosphoSitePlus
K307 Sumoylation PhosphoSitePlus
K307 Ubiquitination PhosphoSitePlus
K331 Sumoylation PhosphoSitePlus
K331 Ubiquitination PhosphoSitePlus
K361 Sumoylation PhosphoSitePlus
C418 Methylation IEDB 31844290
S431 Phosphorylation PhosphoSitePlus
K466 Ubiquitination PhosphoSitePlus
K482 Ubiquitination PhosphoSitePlus


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation O75030 (MITF) S409 Q9Y6X2 (PIAS3) unknown eFIP 22316093


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K230 N230 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
C418 F418 Biomuta DOID:1612 / breast cancer [ cosmic ]
S431 I431 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]