iPTMnet Report for Q9Y6R4 (MAP3K4)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9Y6R4 / M3K4_HUMAN
Protein Name Mitogen-activated protein kinase kinase kinase 4
Gene Name Name: MAP3K4
Synonyms:KIAA0213,MAPKKK4,MEKK4,MTK1;
Organism Homo sapiens (Human)

PRO ID PR:Q9Y6R4
DAG View
PRO Name mitogen-activated protein kinase kinase kinase 4 (human)
Definition A mitogen-activated protein kinase kinase kinase 4 that is encoded in the genome of human.
Short Label hMAP3K4
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9Y6R4 (MAP3K4) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S63 Phosphorylation PhosphoSitePlus
S66 Phosphorylation PhosphoSitePlus
S72 Phosphorylation PhosphoSitePlus
Y81 Phosphorylation PhosphoSitePlus
S84 Phosphorylation PhosphoSitePlus
S87 Phosphorylation PhosphoSitePlus
K98 Acetylation PhosphoSitePlus
Y138 Phosphorylation PhosphoSitePlus
Y140 Phosphorylation PhosphoSitePlus
S173 Phosphorylation PhosphoSitePlus
S201 O-Glycosylation GlyGen 23301498, 28657654, 29351928
S253 Phosphorylation PhosphoSitePlus
T300 O-Glycosylation GlyGen 23301498, 28657654, 29351928
S431 Phosphorylation PhosphoSitePlus   UniProt 23186163
S435 Phosphorylation PhosphoSitePlus
Y442 Phosphorylation PhosphoSitePlus
T447 Phosphorylation PhosphoSitePlus   UniProt 23186163
S456 Phosphorylation PhosphoSitePlus   UniProt 21406692
S457 Phosphorylation PhosphoSitePlus   UniProt 21406692
T458 Phosphorylation PhosphoSitePlus   UniProt 21406692
S461 Phosphorylation PhosphoSitePlus   UniProt 21406692
S481 Phosphorylation PhosphoSitePlus   UniProt 23186163
S499 Phosphorylation PhosphoSitePlus   UniProt 19369195, 23186163
Y582 Phosphorylation PhosphoSitePlus
S798 Phosphorylation PhosphoSitePlus
S835 Phosphorylation PhosphoSitePlus
K890 Acetylation PhosphoSitePlus
S979 Phosphorylation PhosphoSitePlus
S1068 Phosphorylation PhosphoSitePlus
Y1076 Phosphorylation PhosphoSitePlus
S1135 Phosphorylation PhosphoSitePlus
S1148 Phosphorylation PhosphoSitePlus
S1159 Phosphorylation PhosphoSitePlus
S1178 Phosphorylation PhosphoSitePlus
S1252 Phosphorylation PhosphoSitePlus   UniProt 23186163
S1268 Phosphorylation PhosphoSitePlus
S1270 Phosphorylation PhosphoSitePlus
T1271 Phosphorylation PhosphoSitePlus
S1274 Phosphorylation PhosphoSitePlus   UniProt 23186163
S1282 Phosphorylation PhosphoSitePlus
Y1405 Phosphorylation PhosphoSitePlus
T1494 Phosphorylation Q9Y6R4 (MAP3K4) PhosphoSitePlus   Signor 17242196
T1505 Phosphorylation PhosphoSitePlus
Y1548 Phosphorylation PhosphoSitePlus
Y1556 Phosphorylation PhosphoSitePlus
K1575 Ubiquitination PhosphoSitePlus
S1579 Phosphorylation PhosphoSitePlus
S1584 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S431 Phosphorylation HPRD 19651622
T447 Phosphorylation HPRD 19413330, 19651622
S456 Phosphorylation HPRD 19651622
S457 Phosphorylation HPRD 19651622
T458 Phosphorylation HPRD 19651622
S461 Phosphorylation HPRD 19651622
S499 Phosphorylation HPRD 19651622
Site PTM Type PTM Enzyme Score Source PMID
S431 Phosphorylation HPRD 19651622
T447 Phosphorylation HPRD 19413330, 19651622
S456 Phosphorylation HPRD 19651622
S457 Phosphorylation HPRD 19651622
T458 Phosphorylation HPRD 19651622
S461 Phosphorylation HPRD 19651622
S499 Phosphorylation HPRD 19651622
S1159 Phosphorylation PhosphoSitePlus


Q9Y6R4 (MAP3K4) as PTM Enzyme



Substrate Site Score Source PMID
Q9Y6R4 (MAP3K4) T1494 PhosphoSitePlus   Signor 17242196


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S66 C66 Biomuta DOID:1324 / lung cancer [ cosmic, icgc, tcga ]
S72 T72 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
S87 N87 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K98 R98 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:1612 / breast cancer [ cosmic, cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic, icgc, cosmic ]
Y138 * Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S201 F201 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S201 C201 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
T300 A300 Biomuta DOID:263 / kidney cancer [ cosmic ]
T300 N300 Biomuta DOID:363 / uterine cancer [ icgc ]
T447 I447 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
T458 M458 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S499 T499 Biomuta DOID:10534 / stomach cancer [ cosmic ]
Y582 C582 Biomuta DOID:4159 / skin cancer [ cosmic ]
S835 L835 Biomuta DOID:1324 / lung cancer [ cosmic ]
S835 * Biomuta DOID:1612 / breast cancer [ cosmic ]
S1068 I1068 Biomuta DOID:1324 / lung cancer [ cosmic ]
S1068 R1068 Biomuta DOID:363 / uterine cancer [ icgc ]
S1159 G1159 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S1270 F1270 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
Y1405 C1405 Biomuta DOID:5041 / esophageal cancer [ cosmic, icgc ]
T1505 I1505 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]