iPTMnet Report for Q9Y6R0 (NUMBL)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9Y6R0 / NUMBL_HUMAN
Protein Name Numb-like protein
Gene Name Name: NUMBL
Organism Homo sapiens (Human)

PRO ID PR:Q9Y6R0
DAG View
PRO Name Numb-like protein (human)
Definition A Numb-like protein that is encoded in the genome of human.
Short Label hNUMBL
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9Y6R0 (NUMBL) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S48 Phosphorylation PhosphoSitePlus
T209 Phosphorylation PhosphoSitePlus
S224 Phosphorylation PhosphoSitePlus   UniProt 23186163
S228 Phosphorylation PhosphoSitePlus   UniProt 23186163
T251 Phosphorylation HPRD 17081983
S263 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 17081983, ...20068231
T265 Phosphorylation HPRD   PhosphoSitePlus 20068231
T268 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648, 20068231
T269 Phosphorylation HPRD 20068231
S270 Phosphorylation PhosphoSitePlus
T279 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648
T285 O-Glycosylation GlyGen 30379171, 28657654
S305 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
R307 Methylation PhosphoSitePlus
S313 Phosphorylation PhosphoSitePlus
S317 Phosphorylation PhosphoSitePlus
S324 Phosphorylation IEDB   phospho.ELM   PhosphoSitePlus 17081983, 27869121
T409 Phosphorylation PhosphoSitePlus
S411 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 17081983, 20068231, 18452278
S421 Phosphorylation HPRD   PhosphoSitePlus 17081983
S594 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S224 F224 Biomuta DOID:4159 / skin cancer [ cosmic ]
S263 F263 Biomuta DOID:1319 / brain cancer [ cosmic ]
R307 C307 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:10283 / prostate cancer [ cosmic ] DOID:9253 / gastrointestinal stromal tumor [ cosmic ]
S317 L317 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]