iPTMnet Report for Q9Y6M7 (SLC4A7)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9Y6M7 / S4A7_HUMAN
Protein Name Sodium bicarbonate cotransporter 3
Gene Name Name: SLC4A7
Synonyms:BT,NBC2,NBC2B,NBC3,NBCn1,SBC2,SLC4A6;
Organism Homo sapiens (Human)

PRO ID PR:Q9Y6M7
DAG View
PRO Name sodium bicarbonate cotransporter 3 (human)
Definition A sodium bicarbonate cotransporter 3 that is encoded in the genome of human.
Short Label hSLC4A7
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9Y6M7 (SLC4A7) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K23 Ubiquitination PhosphoSitePlus
S26 Phosphorylation PhosphoSitePlus
T30 Phosphorylation PhosphoSitePlus
K31 Ubiquitination PhosphoSitePlus
K34 Ubiquitination PhosphoSitePlus
S39 Phosphorylation PhosphoSitePlus
Y44 Phosphorylation PhosphoSitePlus
S52 Phosphorylation PhosphoSitePlus
S55 Phosphorylation PhosphoSitePlus   UniProt 23186163
S76 Phosphorylation PhosphoSitePlus
S84 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
S86 Phosphorylation PhosphoSitePlus
Y87 Phosphorylation PhosphoSitePlus
T89 Phosphorylation PhosphoSitePlus
S91 Phosphorylation PhosphoSitePlus
T114 Phosphorylation PhosphoSitePlus
Y121 Phosphorylation PhosphoSitePlus
Y127 Phosphorylation PhosphoSitePlus
K130 Ubiquitination PhosphoSitePlus
T132 Phosphorylation PhosphoSitePlus
K137 Ubiquitination PhosphoSitePlus
S150 Phosphorylation PhosphoSitePlus
Y153 Phosphorylation PhosphoSitePlus
T156 Phosphorylation PhosphoSitePlus
L165 Phosphorylation UniProt 20068231
S167 Phosphorylation PhosphoSitePlus
C168 Phosphorylation UniProt 18669648, 21406692, 20068231, ...19690332
S181 Phosphorylation PhosphoSitePlus
T182 Phosphorylation PhosphoSitePlus
S197 Phosphorylation PhosphoSitePlus
S203 Phosphorylation PhosphoSitePlus
T225 Phosphorylation PhosphoSitePlus
S226 Phosphorylation PhosphoSitePlus
S233 Phosphorylation PhosphoSitePlus
K240 Ubiquitination PhosphoSitePlus
S242 Phosphorylation PhosphoSitePlus   UniProt 21406692, 23186163
S255 Phosphorylation UniProt 20068231
R258 Phosphorylation UniProt 18669648, 21406692, 20068231, ...19690332
S260 Phosphorylation PhosphoSitePlus   UniProt 20068231
T263 Phosphorylation UniProt 18669648, 21406692, 20068231, ...19690332
G264 Phosphorylation UniProt 20068231
S266 Phosphorylation PhosphoSitePlus
A267 Phosphorylation UniProt 18669648, 21406692, 20068231, ...19690332
S271 Phosphorylation PhosphoSitePlus
S297 Phosphorylation PhosphoSitePlus
S317 Phosphorylation PhosphoSitePlus
S382 Phosphorylation phospho.ELM 18669648
S390 Phosphorylation PhosphoSitePlus
S392 Phosphorylation PhosphoSitePlus
S400 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S403 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 21406692
S407 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
T408 Phosphorylation PhosphoSitePlus
S412 Phosphorylation PhosphoSitePlus
K421 Ubiquitination PhosphoSitePlus
S429 Phosphorylation PhosphoSitePlus
T459 Phosphorylation PhosphoSitePlus
Y481 Phosphorylation PhosphoSitePlus
S487 Phosphorylation PhosphoSitePlus
T490 Phosphorylation PhosphoSitePlus
T493 Phosphorylation PhosphoSitePlus
K503 Ubiquitination PhosphoSitePlus
K539 Ubiquitination PhosphoSitePlus
K546 Ubiquitination PhosphoSitePlus
K548 Ubiquitination PhosphoSitePlus
S556 Phosphorylation PhosphoSitePlus   UniProt 23186163
T557 Phosphorylation PhosphoSitePlus   UniProt 23186163
T559 Phosphorylation PhosphoSitePlus
T563 Phosphorylation PhosphoSitePlus
K590 Ubiquitination PhosphoSitePlus
T663 Phosphorylation PhosphoSitePlus
K742 Phosphorylation UniProt 19690332
P771 Phosphorylation UniProt 21406692, 20068231
P774 Phosphorylation UniProt 18669648, 20068231
N776 N-Glycosylation GlyGen   UniProt 19349973, 24190977
A780 Phosphorylation UniProt 18669648
K784 Ubiquitination PhosphoSitePlus
N786 N-Glycosylation GlyGen   UniProt 19349973, 24190977
N791 N-Glycosylation GlyGen   UniProt 19349973, 24190977
N796 N-Glycosylation GlyGen 24190977
S800 O-Glycosylation GlyGen 34019948, 34725712, 35289036, ...28510447
C802 Methylation IEDB 31844290
K803 Ubiquitination PhosphoSitePlus
K854 Ubiquitination PhosphoSitePlus
T867 Phosphorylation PhosphoSitePlus
E1007 Phosphorylation UniProt 21406692, 20068231
V1010 Phosphorylation UniProt 18669648, 20068231
F1016 Phosphorylation UniProt 18669648
K1066 Ubiquitination PhosphoSitePlus
Y1073 Phosphorylation UniProt 19690332
V1077 Phosphorylation UniProt 19690332
S1102 Phosphorylation UniProt 21406692, 20068231
A1105 Phosphorylation UniProt 18669648, 20068231
V1106 Phosphorylation UniProt 21406692, 20068231
P1109 Phosphorylation UniProt 18669648, 20068231
M1111 Phosphorylation UniProt 18669648
L1115 Phosphorylation UniProt 18669648
K1142 Ubiquitination PhosphoSitePlus
K1144 Acetylation PhosphoSitePlus
K1151 Acetylation PhosphoSitePlus
T1167 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 19690332, 18220336
S1176 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 19690332, 20068231, ...18220336
K1183 Ubiquitination PhosphoSitePlus
K1186 Ubiquitination PhosphoSitePlus
S1188 Phosphorylation PhosphoSitePlus   UniProt 19690332
S1194 Phosphorylation PhosphoSitePlus
S1198 Phosphorylation PhosphoSitePlus
D1201 Phosphorylation UniProt 19690332
K1206 Ubiquitination PhosphoSitePlus
Y1207 Phosphorylation PhosphoSitePlus
S1213 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 15144186
Site PTM Type PTM Enzyme Score Source PMID
Y44 Phosphorylation HPRD 18578522
S52 Phosphorylation HPRD 20068231
S55 Phosphorylation HPRD 18767875
S84 Phosphorylation HPRD 18767875, 20068231
S86 Phosphorylation HPRD 17081983
Y87 Phosphorylation HPRD 17081983
S233 Phosphorylation HPRD 18578522, 20068231
S242 Phosphorylation HPRD 18767875, 18578522, 20068231
S400 Phosphorylation HPRD 19651622, 18578522, 18669648, ...20068231
S403 Phosphorylation HPRD 19651622, 18669648, 20068231
S407 Phosphorylation HPRD 18669648
Y481 Phosphorylation HPRD 20166139
S487 Phosphorylation HPRD 20166139
T490 Phosphorylation HPRD 20166139
T493 Phosphorylation HPRD 20166139
S556 Phosphorylation HPRD 18578522
T557 Phosphorylation HPRD 18578522, 20068231
T559 Phosphorylation HPRD 18578522
T563 Phosphorylation HPRD 20068231
T1167 Phosphorylation HPRD 18669648, 20068231
S1176 Phosphorylation HPRD 18578522, 18669648, 20068231
S1213 Phosphorylation HPRD 18669648, 15144186
Site PTM Type PTM Enzyme Score Source PMID
S19 Phosphorylation PhosphoSitePlus
S251 Phosphorylation PhosphoSitePlus
S264 Phosphorylation PhosphoSitePlus
S267 Phosphorylation PhosphoSitePlus
K1071 Methylation PhosphoSitePlus
K1071 Ubiquitination PhosphoSitePlus
S1077 Phosphorylation PhosphoSitePlus
S1082 Phosphorylation PhosphoSitePlus
K1087 Ubiquitination PhosphoSitePlus
K1092 Ubiquitination PhosphoSitePlus
S1095 Phosphorylation PhosphoSitePlus
K1102 Ubiquitination PhosphoSitePlus
T1104 Phosphorylation PhosphoSitePlus
S1106 Phosphorylation PhosphoSitePlus
S1109 Phosphorylation PhosphoSitePlus
K1112 Ubiquitination PhosphoSitePlus
S1115 Phosphorylation PhosphoSitePlus
K1117 Ubiquitination PhosphoSitePlus
S1119 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S242 Phosphorylation PhosphoSitePlus
S255 Phosphorylation PhosphoSitePlus
S258 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y37 Phosphorylation PhosphoSitePlus
S152 Phosphorylation PhosphoSitePlus
S165 Phosphorylation PhosphoSitePlus
S168 Phosphorylation PhosphoSitePlus
S176 Phosphorylation PhosphoSitePlus
K177 Ubiquitination PhosphoSitePlus
S186 Phosphorylation PhosphoSitePlus
S189 Phosphorylation PhosphoSitePlus
S193 Phosphorylation PhosphoSitePlus
T194 Phosphorylation PhosphoSitePlus
T343 Phosphorylation PhosphoSitePlus
K993 Ubiquitination PhosphoSitePlus
S996 Phosphorylation PhosphoSitePlus
K1003 Ubiquitination PhosphoSitePlus
T1005 Phosphorylation PhosphoSitePlus
S1007 Phosphorylation PhosphoSitePlus
S1010 Phosphorylation PhosphoSitePlus
K1013 Ubiquitination PhosphoSitePlus
S1016 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S726 Phosphorylation PhosphoSitePlus
K736 Methylation PhosphoSitePlus
K736 Ubiquitination PhosphoSitePlus
S742 Phosphorylation PhosphoSitePlus
S747 Phosphorylation PhosphoSitePlus
K752 Ubiquitination PhosphoSitePlus
K757 Ubiquitination PhosphoSitePlus
S760 Phosphorylation PhosphoSitePlus
K767 Ubiquitination PhosphoSitePlus
T769 Phosphorylation PhosphoSitePlus
S771 Phosphorylation PhosphoSitePlus
S774 Phosphorylation PhosphoSitePlus
K777 Ubiquitination PhosphoSitePlus
S780 Phosphorylation PhosphoSitePlus
K782 Ubiquitination PhosphoSitePlus
S784 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S19 Phosphorylation PhosphoSitePlus
S1172 Phosphorylation PhosphoSitePlus
K1182 Methylation PhosphoSitePlus
K1182 Ubiquitination PhosphoSitePlus
S1188 Phosphorylation PhosphoSitePlus
S1193 Phosphorylation PhosphoSitePlus
K1198 Ubiquitination PhosphoSitePlus
K1203 Ubiquitination PhosphoSitePlus
S1206 Phosphorylation PhosphoSitePlus
K1213 Ubiquitination PhosphoSitePlus
T1215 Phosphorylation PhosphoSitePlus
S1217 Phosphorylation PhosphoSitePlus
S1220 Phosphorylation PhosphoSitePlus
K1223 Ubiquitination PhosphoSitePlus
S1226 Phosphorylation PhosphoSitePlus
K1228 Ubiquitination PhosphoSitePlus
S1230 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S55 C55 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
S84 Y84 Biomuta DOID:3571 / liver cancer [ cosmic ]
S86 C86 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
T114 M114 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
K130 N130 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S150 G150 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S181 N181 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S203 C203 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S203 A203 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
T225 N225 Biomuta DOID:3571 / liver cancer [ cosmic ]
R258 C258 Biomuta DOID:1324 / lung cancer [ cosmic ]
S260 F260 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
S392 N392 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S400 N400 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S403 N403 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S412 G412 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S487 P487 Biomuta DOID:1319 / brain cancer [ cosmic ]
S556 F556 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
T663 K663 Biomuta DOID:10534 / stomach cancer [ cosmic ]
P774 H774 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
N776 H776 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
K784 E784 Biomuta DOID:1324 / lung cancer [ cosmic ]
N791 S791 Biomuta [ cosmic ] DOID:1115 / sarcoma [ icgc ]
S800 F800 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
S800 Y800 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S800 T800 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
M1111 T1111 Biomuta DOID:3571 / liver cancer [ cosmic ]
K1144 T1144 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S1188 * Biomuta DOID:2394 / ovarian cancer [ cosmic ]
S1188 I1188 Biomuta DOID:2531 / hematologic cancer [ icgc ]
K1228 N1228 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]