iPTMnet Report for Q9Y6M1 (IGF2BP2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9Y6M1 / IF2B2_HUMAN
Protein Name Insulin-like growth factor 2 mRNA-binding protein 2
Gene Name Name: IGF2BP2
Synonyms:IMP2,VICKZ2;
Organism Homo sapiens (Human)

PRO ID PR:Q9Y6M1
DAG View
PRO Name insulin-like growth factor 2 mRNA-binding protein 2 (human)
Definition An insulin-like growth factor 2 mRNA-binding protein 2 that is encoded in the genome of human.
Short Label hIGF2BP2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9Y6M1 (IGF2BP2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 22814378, 22223895
Y6 Phosphorylation PhosphoSitePlus
S11 Phosphorylation PhosphoSitePlus   UniProt 23186163
T15 Phosphorylation PhosphoSitePlus
Y40 Phosphorylation PhosphoSitePlus
Y45 Phosphorylation PhosphoSitePlus
Y73 Phosphorylation PhosphoSitePlus
K77 Methylation PhosphoSitePlus
K77 Ubiquitination PhosphoSitePlus
K78 Methylation PhosphoSitePlus
K139 Ubiquitination PhosphoSitePlus
Y148 Phosphorylation PhosphoSitePlus
S161 Phosphorylation PhosphoSitePlus
S162 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 18669648, 21406692, 28753127
S164 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 21406692, 23186163, 18669648, ...28753127, 19690332
T186 Phosphorylation PhosphoSitePlus
S187 Phosphorylation PhosphoSitePlus
K221 Ubiquitination PhosphoSitePlus
T223 Phosphorylation PhosphoSitePlus
K232 Ubiquitination PhosphoSitePlus
K240 Ubiquitination PhosphoSitePlus
T269 Phosphorylation PhosphoSitePlus
K270 Ubiquitination PhosphoSitePlus
K278 Ubiquitination PhosphoSitePlus
K292 Ubiquitination PhosphoSitePlus
T324 Phosphorylation PhosphoSitePlus
T326 Phosphorylation PhosphoSitePlus
T330 Phosphorylation PhosphoSitePlus
S336 Phosphorylation PhosphoSitePlus
K451 Ubiquitination PhosphoSitePlus
S460 Phosphorylation PhosphoSitePlus
K462 Ubiquitination PhosphoSitePlus
K487 Methylation PhosphoSitePlus
K487 Ubiquitination PhosphoSitePlus
K497 Sumoylation PhosphoSitePlus
K497 Ubiquitination PhosphoSitePlus
K505 Sumoylation PhosphoSitePlus
K505 Ubiquitination PhosphoSitePlus
K509 Sumoylation PhosphoSitePlus
K509 Ubiquitination PhosphoSitePlus
S518 Phosphorylation PhosphoSitePlus
K530 Ubiquitination PhosphoSitePlus
T550 Phosphorylation PhosphoSitePlus
K583 Ubiquitination PhosphoSitePlus
K588 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y6 Phosphorylation HPRD 20068231
T15 Phosphorylation HPRD 20068231
S161 Phosphorylation HPRD 20068231
S162 Phosphorylation HPRD 19413330, 20058876, 19664994, ...19664995, 19651622, 18669648, 18707149, 19415658, 20068231
S164 Phosphorylation HPRD 19413330, 17322306, 18767875, ...19664994, 19664995, 18452278, 19651622, 18669648, 19415658, 20068231
T269 Phosphorylation HPRD 18452278
Site PTM Type PTM Enzyme Score Source PMID
Y6 Phosphorylation HPRD 20068231
T15 Phosphorylation HPRD 20068231
S161 Phosphorylation HPRD 20068231
S162 Phosphorylation HPRD 19413330, 20058876, 19664994, ...19664995, 19651622, 18669648, 18707149, 19415658, 20068231
S164 Phosphorylation HPRD 19413330, 17322306, 18767875, ...19664994, 19664995, 18452278, 19651622, 18669648, 19415658, 20068231
T269 Phosphorylation HPRD 18452278


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T15 N15 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
K77 E77 Biomuta DOID:1324 / lung cancer [ cosmic ]
S162 T162 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ] DOID:3571 / liver cancer [ cosmic, cosmic ]
S187 C187 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
K530 N530 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]