Protein Information

Cytoscape View

UniProt AC / UniProt ID Q9Y6K9 / NEMO_HUMAN
Protein Name NF-kappa-B essential modulator
Gene Name Name: IKBKG
Organism Homo sapiens (Human)

DAG View
PRO Name NF-kappa-B essential modulator (human)
Definition An NF-kappa-B essential modulator that is encoded in the genome of human.
Short Label hIKBKG
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

Q9Y6K9 (IKBKG) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
S8 Phosphorylation PhosphoSitePlus   RLIMS-P 27929056
S17 Phosphorylation PhosphoSitePlus   RLIMS-P 27929056
S31 Phosphorylation O14920 (IKBKB) phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 12657630, 27929056
S43 Phosphorylation O14920 (IKBKB) phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 12657630, 27929056, 17977820
T50 Phosphorylation Q14164 (IKBKE) neXtProt   PhosphoSitePlus 21138416
S68 Phosphorylation O14920 (IKBKB) PhosphoSitePlus   Signor   UniProt 17977820
S85 Phosphorylation Q13315 (ATM) , O14920 (IKBKB) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 17977820, 16497931, 24068928
K111 Ubiquitination PhosphoSitePlus   UniProt 21455181
K118 Ubiquitination PhosphoSitePlus
K139 Ubiquitination UniProt 21455181
S141 Phosphorylation Q14164 (IKBKE) neXtProt 21138416
K143 Ubiquitination PhosphoSitePlus   UniProt 21455181
S148 Phosphorylation Q14164 (IKBKE) neXtProt 21138416
K165 Ubiquitination PhosphoSitePlus
S178 Phosphorylation PhosphoSitePlus
S196 Phosphorylation Q14164 (IKBKE) neXtProt   PhosphoSitePlus 21138416
S208 Phosphorylation Q14164 (IKBKE) neXtProt 21138416
K226 Ubiquitination UniProt 21455181
K246 Ubiquitination PhosphoSitePlus   UniProt 21455181
S247 Phosphorylation Q14164 (IKBKE) neXtProt 21138416
S252 Phosphorylation PhosphoSitePlus
K255 Acetylation PhosphoSitePlus
K255 Ubiquitination PhosphoSitePlus
K264 Ubiquitination PhosphoSitePlus   UniProt 21455181
K277 Sumoylation PhosphoSitePlus
K277 Ubiquitination PhosphoSitePlus   UniProt 14651848, 21455181
K283 Ubiquitination PhosphoSitePlus   UniProt 21455181
K285 Ubiquitination PRO   PhosphoSitePlus   UniProt 19136968, 15620648, 21455181
K292 Ubiquitination PhosphoSitePlus   UniProt 21455181
T297 Phosphorylation PhosphoSitePlus
K302 Ubiquitination UniProt 21455181
Y308 Phosphorylation PhosphoSitePlus
K309 Sumoylation PhosphoSitePlus
K309 Ubiquitination PhosphoSitePlus   UniProt 20010814, 14651848, 19136968, ...21455181
K321 Ubiquitination PhosphoSitePlus   UniProt 20010814
K325 Ubiquitination PhosphoSitePlus
K326 Ubiquitination PhosphoSitePlus   UniProt 21455181
K342 Ubiquitination PhosphoSitePlus
K344 Ubiquitination PhosphoSitePlus
K358 Ubiquitination PhosphoSitePlus
Y374 Phosphorylation P12931 (SRC) PhosphoSitePlus 23131831
S376 Phosphorylation O14920 (IKBKB) phospho.ELM   PhosphoSitePlus   Signor   UniProt 12657630
S377 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S383 Phosphorylation PhosphoSitePlus
S387 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 24275569, 24012789
K399 Ubiquitination PhosphoSitePlus   UniProt 14695475
Site PTM Type PTM Enzyme Score Source PMID
S31 Phosphorylation O14920 (IKBKB) HPRD   PRO 12657630
S43 Phosphorylation O14920 (IKBKB) HPRD   PRO 12657630
S68 Phosphorylation PRO 17977820
S85 Phosphorylation PRO 16497931
T297 Phosphorylation HPRD 20068231
S376 Phosphorylation O14920 (IKBKB) HPRD   PRO 18691976, 12657630
S377 Phosphorylation HPRD 18691976, 18669648, 20068231
S383 Phosphorylation HPRD 20068231
S387 Phosphorylation HPRD 18669648

Q9Y6K9 (IKBKG) as PTM Enzyme

Substrate Site Score Source PMID
O14920 (IKBKB) S181 neXtProt 18037881
P25963 (NFKBIA) S32 HPRD 16319058
Q04206 (RELA) S536 Signor 15489227


PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000047980 (hIKBKG/Ubiq:1) ubK285 PRO
PR:000036612 (hIKBKG/iso:1/Phos:1) pS31,pS43,pS376 PRO 12657630
PR:000036613 (hIKBKG/iso:1/Phos:2) pS68 PRO 17977820
PR:000036614 (hIKBKG/iso:1/Phos:3) pS85 PRO 16497931

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S17 T17 Biomuta DOID:1324 / lung cancer [ tcga ]
S31 T31 Biomuta DOID:363 / uterine cancer [ tcga ]
S43 L43 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]