iPTMnet Report for Q9Y6K5 (OAS3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9Y6K5 / OAS3_HUMAN
Protein Name 2'-5'-oligoadenylate synthase 3
Gene Name Name: OAS3
ORFNames:P/OKcl.4;
Organism Homo sapiens (Human)

PRO ID PR:Q9Y6K5
DAG View
PRO Name 2'-5'-oligoadenylate synthase 3 (human)
Definition A 2'-5'-oligoadenylate synthase 3 that is encoded in the genome of human.
Short Label hOAS3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9Y6K5 (OAS3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 22814378
K59 Acetylation PhosphoSitePlus
R65 Methylation PhosphoSitePlus
K70 Acetylation PhosphoSitePlus
C183 Methylation IEDB 31844290
S351 Phosphorylation PhosphoSitePlus
K364 Ubiquitination PhosphoSitePlus
T365 Phosphorylation HPRD   PhosphoSitePlus   UniProt 23186163, 20068231
S369 Phosphorylation PhosphoSitePlus
K370 Ubiquitination PhosphoSitePlus
S371 Phosphorylation PhosphoSitePlus
Y376 Phosphorylation PhosphoSitePlus
R378 Methylation PhosphoSitePlus
K414 Acetylation IEDB 34357683
K425 Ubiquitination PhosphoSitePlus
K435 Ubiquitination PhosphoSitePlus
C444 Methylation IEDB 31844290
K452 Ubiquitination PhosphoSitePlus
S454 Phosphorylation PhosphoSitePlus
K458 Ubiquitination PhosphoSitePlus
S461 O-Glycosylation GlyGen 30379171
R464 Methylation PhosphoSitePlus
Y486 Phosphorylation PhosphoSitePlus
K580 Ubiquitination PhosphoSitePlus
K597 Acetylation PhosphoSitePlus
K693 Sumoylation PhosphoSitePlus
K785 Ubiquitination PhosphoSitePlus
S792 Phosphorylation PhosphoSitePlus
K795 Ubiquitination PhosphoSitePlus
K807 Ubiquitination PhosphoSitePlus
K958 Methylation PhosphoSitePlus
K958 Ubiquitination PhosphoSitePlus
R963 Methylation PhosphoSitePlus
C1009 Methylation IEDB 31844290
K1021 Ubiquitination PhosphoSitePlus
K1028 Ubiquitination PhosphoSitePlus
K1033 Ubiquitination PhosphoSitePlus
K1059 Ubiquitination PhosphoSitePlus
K1084 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K70 N70 Biomuta DOID:9253 / gastrointestinal stromal tumor [ cosmic ]
S371 I371 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S461 L461 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
R464 Q464 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
R464 W464 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K693 I693 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S792 Y792 Biomuta DOID:363 / uterine cancer [ icgc ]
S792 F792 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:5041 / esophageal cancer [ cosmic ]