iPTMnet Report for Q9Y6K1 (DNMT3A)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9Y6K1 / DNM3A_HUMAN
Protein Name DNA (cytosine-5)-methyltransferase 3A
Gene Name Name: DNMT3A
Organism Homo sapiens (Human)

PRO ID PR:Q9Y6K1
DAG View
PRO Name DNA (cytosine-5)-methyltransferase 3A (human)
Definition A DNA (cytosine-5)-methyltransferase 3A that is encoded in the genome of human.
Short Label hDNMT3A
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9Y6K1 (DNMT3A) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
R23 Methylation PhosphoSitePlus
T65 Phosphorylation PhosphoSitePlus
S75 Phosphorylation PhosphoSitePlus
S105 Phosphorylation PhosphoSitePlus   UniProt 18669648, 23186163, 21406692, ...17081983
T138 Phosphorylation PhosphoSitePlus
T156 Phosphorylation PhosphoSitePlus
R171 Methylation PhosphoSitePlus
S178 Phosphorylation PhosphoSitePlus
S179 Phosphorylation PhosphoSitePlus
S199 Phosphorylation PhosphoSitePlus
K200 Ubiquitination PhosphoSitePlus
S236 Phosphorylation PhosphoSitePlus
S243 Phosphorylation PhosphoSitePlus   UniProt 21406692, 20068231
S255 Phosphorylation PhosphoSitePlus   UniProt 21406692
T261 Phosphorylation PhosphoSitePlus   UniProt 21406692
S267 Phosphorylation PhosphoSitePlus   UniProt 21406692
K276 Ubiquitination PhosphoSitePlus
K299 Ubiquitination PhosphoSitePlus
K367 Ubiquitination PhosphoSitePlus
S377 Phosphorylation PhosphoSitePlus
K382 Ubiquitination PhosphoSitePlus
S390 Phosphorylation PhosphoSitePlus
S393 Phosphorylation PhosphoSitePlus
K420 Ubiquitination PhosphoSitePlus
K468 Sumoylation PhosphoSitePlus
S638 Phosphorylation PhosphoSitePlus
T645 Phosphorylation PhosphoSitePlus
K721 Ubiquitination PhosphoSitePlus
R771 Methylation PhosphoSitePlus
K783 Ubiquitination PhosphoSitePlus
K812 Ubiquitination PhosphoSitePlus
S839 Phosphorylation PhosphoSitePlus
K844 Ubiquitination PhosphoSitePlus
R882 Methylation PhosphoSitePlus
S894 Phosphorylation PhosphoSitePlus
K906 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S75 Phosphorylation HPRD 20068231
S105 Phosphorylation HPRD 19413330, 18669648, 17081983
S243 Phosphorylation HPRD 20068231
S255 Phosphorylation HPRD 19664995, 20068231
T261 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
S54 Phosphorylation HPRD 20068231
S66 Phosphorylation HPRD 19664995, 20068231
T72 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
S75 Phosphorylation HPRD 20068231
S105 Phosphorylation HPRD 19413330, 18669648, 17081983


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R23 Q23 Biomuta DOID:1319 / brain cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic ]
T65 M65 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T72 M72 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:1612 / breast cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ] DOID:4606 / bile duct cancer [ cosmic ]
S75 Y75 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
S105 R105 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
T138 I138 Biomuta DOID:1324 / lung cancer [ cosmic ]
T156 I156 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S236 F236 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
T261 M261 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:1612 / breast cancer [ cosmic ]
S267 F267 Biomuta DOID:4159 / skin cancer [ cosmic ]
K299 N299 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
K468 R468 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S638 F638 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S638 C638 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
T645 A645 Biomuta [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ]
K721 R721 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
K721 N721 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
K721 E721 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
R771 * Biomuta DOID:4362 / cervical cancer [ cosmic ] DOID:4606 / bile duct cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ]
R771 Q771 Biomuta [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ] DOID:2531 / hematologic cancer [ cosmic ] DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic ]
R771 G771 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
R771 L771 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S839 Y839 Biomuta DOID:2531 / hematologic cancer [ cosmic, icgc ]
K844 E844 Biomuta DOID:3571 / liver cancer [ cosmic ]
R882 C882 Biomuta [ cosmic ] DOID:10283 / prostate cancer [ cosmic, icgc ] DOID:1324 / lung cancer [ cosmic, icgc ] DOID:2531 / hematologic cancer [ cosmic, icgc ] DOID:4606 / bile duct cancer [ cosmic ] DOID:8618 / oral cavity cancer [ cosmic ] DOID:1612 / breast cancer [ cosmic ]
R882 H882 Biomuta [ cosmic ] DOID:1612 / breast cancer [ cosmic, icgc ] DOID:1324 / lung cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic, icgc ] DOID:5158 / pleural cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ] DOID:263 / kidney cancer [ cosmic ] DOID:8618 / oral cavity cancer [ cosmic ]
R882 G882 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ]
R882 L882 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
R882 S882 Biomuta DOID:2531 / hematologic cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic ]
R882 P882 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
K906 * Biomuta DOID:2531 / hematologic cancer [ cosmic ]