iPTMnet Report Q9Y6I3 EPN1

Protein Information

UniProt AC / UniProt ID	Q9Y6I3 / EPN1_HUMAN
Protein Name	Epsin-1
Gene Name	Name: EPN1
Organism	Homo sapiens (Human)

PRO ID	PR:Q9Y6I3 DAG View
PRO Name	epsin-1 (human)
Definition	An epsin-1 that is encoded in the genome of human.
Short Label	hEPN1
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

Q9Y6I3 (EPN1) as Substrate

Condensed View

Search:

Site Select all By amino acid All Serine All Threonine All Tyrosine By position K11 Y17 S18 K23 K69 K86 K97 Y101 K107 Y111 K117 K126 K128 K149 S204 K226 K246 S382 T412 T416 S417 S419 S420 S435 S442 S447 S454 T460 T462 T464 T467 K469 T470 S473 S486 T494 S501 T517 R534 S536 Y548	PTM Type Select all Methylation O-Glycosylation Phosphorylation Ubiquitination	PTM Enzyme Select all P06493 (CDK1)	Score Select all 1 2 3	Source Select all GlyGen IEDB PhosphoSitePlus UniProt neXtProt phospho.ELM	PMID
K11	Ubiquitination		score1	PhosphoSitePlus
Y17	Phosphorylation		score1	PhosphoSitePlus
S18	Phosphorylation		score1	PhosphoSitePlus
K23	Ubiquitination		score1	PhosphoSitePlus
K69	Ubiquitination		score1	PhosphoSitePlus
K86	Ubiquitination		score1	PhosphoSitePlus
K97	Ubiquitination		score1	PhosphoSitePlus
Y101	Phosphorylation		score1	PhosphoSitePlus
K107	Ubiquitination		score1	PhosphoSitePlus
Y111	Phosphorylation		score1	PhosphoSitePlus
K117	Ubiquitination		score1	PhosphoSitePlus
K126	Ubiquitination		score1	PhosphoSitePlus
K128	Ubiquitination		score1	PhosphoSitePlus
K149	Ubiquitination		score1	PhosphoSitePlus
S204	Phosphorylation		score1	PhosphoSitePlus
K226	Ubiquitination		score1	PhosphoSitePlus
K246	Ubiquitination		score1	PhosphoSitePlus
S382	Phosphorylation		score3	neXtProt PhosphoSitePlus UniProt	10764745
S382	Phosphorylation	P06493 (CDK1)	score3	neXtProt PhosphoSitePlus	10764745
T412	Phosphorylation		score1	PhosphoSitePlus
T416	Phosphorylation		score1	PhosphoSitePlus
S417	Phosphorylation		score2	phospho.ELM PhosphoSitePlus	18669648
S419	Phosphorylation		score2	PhosphoSitePlus UniProt	19690332, 24275569
S420	O-Glycosylation		score1	GlyGen	31373491
S420	Phosphorylation		score2	PhosphoSitePlus UniProt	19690332, 24275569
S435	Phosphorylation		score2	PhosphoSitePlus UniProt	23186163, 18669648, 24275569, ...19690332, 20068231
S442	Phosphorylation		score1	PhosphoSitePlus
S447	Phosphorylation		score2	PhosphoSitePlus UniProt	23186163, 24275569
S454	Phosphorylation		score2	PhosphoSitePlus UniProt	23186163, 16964243, 18669648, ...24275569, 19690332, 20068231
T460	Phosphorylation		score2	PhosphoSitePlus UniProt	18669648, 16964243, 20068231, ...19690332
T462	O-Glycosylation		score1	GlyGen	30459171
T462	Phosphorylation		score1	PhosphoSitePlus
T464	Phosphorylation		score2	PhosphoSitePlus UniProt	24275569
T467	Phosphorylation		score1	PhosphoSitePlus
K469	Ubiquitination		score1	PhosphoSitePlus
T470	Phosphorylation		score2	IEDB PhosphoSitePlus UniProt	19690332, 27869121
S473	Phosphorylation		score1	PhosphoSitePlus
S486	Phosphorylation		score1	PhosphoSitePlus
T494	Phosphorylation		score2	PhosphoSitePlus UniProt	18669648, 17081983, 20068231
S501	Phosphorylation		score1	PhosphoSitePlus
T517	O-Glycosylation		score1	GlyGen	36240223, 35254053, 34019948, ...28657654
R534	Methylation		score1	PhosphoSitePlus
S536	O-Glycosylation		score1	GlyGen	36240223, 35254053, 34019948, ...28657654
S536	Phosphorylation		score1	PhosphoSitePlus
Y548	Phosphorylation		score1	PhosphoSitePlus

Search:

	Site Select all By amino acid All Serine By position S17	PTM Type Select all Phosphorylation	PTM Enzyme Select all	Score Select all 1	Source Select all PhosphoSitePlus	PMID
	S17	Phosphorylation		score1	PhosphoSitePlus

Search:

Site Select all By amino acid All Serine All Threonine By position S357 T373 S393 S394 S409 S416 S421 S428 T434 T436 T438 T444 S460 T468 S475 S510 T521 S524	PTM Type Select all Phosphorylation	PTM Enzyme Select all P06493 (CDK1)	Score Select all 0 1	Source Select all HPRD PhosphoSitePlus	PMID
S357	Phosphorylation		score1	HPRD	10764745
S357	Phosphorylation	P06493 (CDK1)	score1	HPRD	10764745
T373	Phosphorylation		score1	PhosphoSitePlus
S393	Phosphorylation		score0	HPRD	20166139
S394	Phosphorylation		score0	HPRD	20166139
S409	Phosphorylation		score0	HPRD	18669648, 20068231
S416	Phosphorylation		score0	HPRD	18669648
S421	Phosphorylation		score0	HPRD	18491316
S428	Phosphorylation		score0	HPRD	18669648, 16964243, 20068231
T434	Phosphorylation		score0	HPRD	18669648, 16964243, 20068231
T436	Phosphorylation		score0	HPRD	18669648, 20068231
T438	Phosphorylation		score0	HPRD	18669648, 20068231
T444	Phosphorylation		score0	HPRD	20068231
S460	Phosphorylation		score0	HPRD	20068231
T468	Phosphorylation		score0	HPRD	18669648, 17081983, 20068231, ...17924679
S475	Phosphorylation		score0	HPRD	20068231
S510	Phosphorylation		score0	HPRD	20068231
T521	Phosphorylation		score0	HPRD	20068231
S524	Phosphorylation		score0	HPRD	20068231

PTM sites affected in variants

Search:

Site Select all By amino acid All Serine All Threonine All Tyrosine By position K11 S17 S18 K23 K69 K107 K128 T373 S393 S417 S419 S421 T438 S447 T464 T467 T468 K469 T494 S524 R534 Y548	Variant Select all * A438 A464 C524 C534 F417 F421 F447 F548 H548 I17 M373 M468 M494 M69 N107 N128 N23 N393 N419 N467 N469 P18 R11	Source Select all Biomuta	Disease [Sample source] Select all DOID:10283 / prostate cancer [ cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ] DOID:263 / kidney cancer [ cosmic ] DOID:363 / uterine cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ] DOID:363 / uterine cancer [ cosmic, icgc ] DOID:4159 / skin cancer [ cosmic, icgc ] DOID:4159 / skin cancer [ icgc ] DOID:4362 / cervical cancer [ cosmic, icgc ] DOID:8618 / oral cavity cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic, icgc ]
K11	R11	Biomuta	DOID:9256 / colorectal cancer [ cosmic, icgc ]
S17	I17	Biomuta	DOID:10534 / stomach cancer [ cosmic ]
S18	*	Biomuta	DOID:1324 / lung cancer [ cosmic ]
S18	P18	Biomuta	DOID:9256 / colorectal cancer [ cosmic ]
K23	N23	Biomuta	DOID:363 / uterine cancer [ cosmic, icgc ]
K69	M69	Biomuta	DOID:263 / kidney cancer [ cosmic ]
K107	N107	Biomuta	DOID:363 / uterine cancer [ cosmic, icgc ]
K128	N128	Biomuta	DOID:363 / uterine cancer [ cosmic, icgc ]
T373	M373	Biomuta	DOID:9256 / colorectal cancer [ cosmic ]
S393	N393	Biomuta	DOID:8618 / oral cavity cancer [ cosmic ]
S417	F417	Biomuta	DOID:4159 / skin cancer [ icgc ]
S419	N419	Biomuta	DOID:8618 / oral cavity cancer [ cosmic ]
S421	F421	Biomuta	DOID:4159 / skin cancer [ cosmic, icgc ]
T438	A438	Biomuta	DOID:10283 / prostate cancer [ cosmic, icgc ]
S447	F447	Biomuta	DOID:4159 / skin cancer [ cosmic, icgc ]
T464	A464	Biomuta	DOID:10283 / prostate cancer [ cosmic, icgc ]
T467	N467	Biomuta	DOID:8618 / oral cavity cancer [ cosmic ]
T468	M468	Biomuta	DOID:363 / uterine cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]
K469	N469	Biomuta	DOID:1324 / lung cancer [ cosmic, icgc ]
T494	M494	Biomuta	DOID:363 / uterine cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]
S524	C524	Biomuta	DOID:4362 / cervical cancer [ cosmic, icgc ]
R534	C534	Biomuta	DOID:4159 / skin cancer [ cosmic, icgc ]
Y548	H548	Biomuta	DOID:9256 / colorectal cancer [ cosmic, icgc ]
Y548	F548	Biomuta	DOID:1324 / lung cancer [ cosmic, icgc ]

PTM Type		Select All, None
Acetylation	N-Glycosylation	O-Glycosylation
C-Glycosylation	S-Glycosylation	Methylation
Myristoylation	Phosphorylation	Sumoylation
Ubiquitination	S-Nitrosylation

Select organisms		Select All, None
Human	Mouse	Rat
Cow	Chicken	Zebrafish
Fruit fly	C. elegans	Baker's yeast
Fission yeast	A. thaliana	Maize
M. truncatula	Rice (japonica)	Rice (indica)

Or input other organisms

iPTMnet Report for Q9Y6I3 (EPN1)

Protein Information

Interactive Sequence View

Q9Y6I3 (EPN1) as Substrate

PTM sites affected in variants