iPTMnet Report for Q9Y6I3 (EPN1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9Y6I3 / EPN1_HUMAN
Protein Name Epsin-1
Gene Name Name: EPN1
Organism Homo sapiens (Human)

PRO ID PR:Q9Y6I3
DAG View
PRO Name epsin-1 (human)
Definition An epsin-1 that is encoded in the genome of human.
Short Label hEPN1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9Y6I3 (EPN1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K11 Ubiquitination PhosphoSitePlus
Y17 Phosphorylation PhosphoSitePlus
S18 Phosphorylation PhosphoSitePlus
K23 Ubiquitination PhosphoSitePlus
K69 Ubiquitination PhosphoSitePlus
K86 Ubiquitination PhosphoSitePlus
K97 Ubiquitination PhosphoSitePlus
Y101 Phosphorylation PhosphoSitePlus
K107 Ubiquitination PhosphoSitePlus
Y111 Phosphorylation PhosphoSitePlus
K117 Ubiquitination PhosphoSitePlus
K126 Ubiquitination PhosphoSitePlus
K128 Ubiquitination PhosphoSitePlus
K149 Ubiquitination PhosphoSitePlus
S204 Phosphorylation PhosphoSitePlus
K226 Ubiquitination PhosphoSitePlus
K246 Ubiquitination PhosphoSitePlus
S382 Phosphorylation neXtProt   PhosphoSitePlus   UniProt 10764745
S382 Phosphorylation P06493 (CDK1) neXtProt   PhosphoSitePlus 10764745
T412 Phosphorylation PhosphoSitePlus
T416 Phosphorylation PhosphoSitePlus
S417 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S419 Phosphorylation PhosphoSitePlus   UniProt 19690332, 24275569
S420 O-Glycosylation GlyGen 31373491
S420 Phosphorylation PhosphoSitePlus   UniProt 19690332, 24275569
S435 Phosphorylation PhosphoSitePlus   UniProt 23186163, 18669648, 24275569, ...19690332, 20068231
S442 Phosphorylation PhosphoSitePlus
S447 Phosphorylation PhosphoSitePlus   UniProt 23186163, 24275569
S454 Phosphorylation PhosphoSitePlus   UniProt 23186163, 16964243, 18669648, ...24275569, 19690332, 20068231
T460 Phosphorylation PhosphoSitePlus   UniProt 18669648, 16964243, 20068231, ...19690332
T462 O-Glycosylation GlyGen 30459171
T462 Phosphorylation PhosphoSitePlus
T464 Phosphorylation PhosphoSitePlus   UniProt 24275569
T467 Phosphorylation PhosphoSitePlus
K469 Ubiquitination PhosphoSitePlus
T470 Phosphorylation IEDB   PhosphoSitePlus   UniProt 19690332, 27869121
S473 Phosphorylation PhosphoSitePlus
S486 Phosphorylation PhosphoSitePlus
T494 Phosphorylation PhosphoSitePlus   UniProt 18669648, 17081983, 20068231
S501 Phosphorylation PhosphoSitePlus
T517 O-Glycosylation GlyGen 36240223, 35254053, 34019948, ...28657654
R534 Methylation PhosphoSitePlus
S536 O-Glycosylation GlyGen 36240223, 35254053, 34019948, ...28657654
S536 Phosphorylation PhosphoSitePlus
Y548 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S17 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S357 Phosphorylation HPRD 10764745
S357 Phosphorylation P06493 (CDK1) HPRD 10764745
T373 Phosphorylation PhosphoSitePlus
S393 Phosphorylation HPRD 20166139
S394 Phosphorylation HPRD 20166139
S409 Phosphorylation HPRD 18669648, 20068231
S416 Phosphorylation HPRD 18669648
S421 Phosphorylation HPRD 18491316
S428 Phosphorylation HPRD 18669648, 16964243, 20068231
T434 Phosphorylation HPRD 18669648, 16964243, 20068231
T436 Phosphorylation HPRD 18669648, 20068231
T438 Phosphorylation HPRD 18669648, 20068231
T444 Phosphorylation HPRD 20068231
S460 Phosphorylation HPRD 20068231
T468 Phosphorylation HPRD 18669648, 17081983, 20068231, ...17924679
S475 Phosphorylation HPRD 20068231
S510 Phosphorylation HPRD 20068231
T521 Phosphorylation HPRD 20068231
S524 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K11 R11 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S17 I17 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S18 * Biomuta DOID:1324 / lung cancer [ cosmic ]
S18 P18 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K23 N23 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K69 M69 Biomuta DOID:263 / kidney cancer [ cosmic ]
K107 N107 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K128 N128 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T373 M373 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S393 N393 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S417 F417 Biomuta DOID:4159 / skin cancer [ icgc ]
S419 N419 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S421 F421 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
T438 A438 Biomuta DOID:10283 / prostate cancer [ cosmic, icgc ]
S447 F447 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
T464 A464 Biomuta DOID:10283 / prostate cancer [ cosmic, icgc ]
T467 N467 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
T468 M468 Biomuta DOID:363 / uterine cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]
K469 N469 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
T494 M494 Biomuta DOID:363 / uterine cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]
S524 C524 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
R534 C534 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
Y548 H548 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
Y548 F548 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]