Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9Y6E0 / STK24_HUMAN
Protein Name Serine/threonine-protein kinase 24
Gene Name Name: STK24
Synonyms:MST3,STK3;
Organism Homo sapiens (Human)

PRO ID PR:Q9Y6E0
DAG View
PRO Name serine/threonine-protein kinase 24 (human)
Definition A serine/threonine-protein kinase 24 that is encoded in the genome of human.
Short Label hSTK24
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9Y6E0 (STK24) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T18 Phosphorylation P17612 (PRKACA) neXtProt   phospho.ELM   PhosphoSitePlus   Signor   UniProt 10644707
K38 Ubiquitination PhosphoSitePlus
K44 Ubiquitination PhosphoSitePlus
S46 Phosphorylation PhosphoSitePlus
K52 Ubiquitination PhosphoSitePlus
Y93 Phosphorylation PhosphoSitePlus
K142 Ubiquitination PhosphoSitePlus
K151 Ubiquitination PhosphoSitePlus
T182 Phosphorylation PhosphoSitePlus   RLIMS-P 22229648
T184 Phosphorylation PhosphoSitePlus
K187 Ubiquitination PhosphoSitePlus
T190 Phosphorylation Q9Y6E0 (STK24) neXtProt   PhosphoSitePlus   Signor   UniProt 23186163, 17046825, 20124694, ...17657516, 19604147
T194 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
K238 Ubiquitination PhosphoSitePlus
K245 Ubiquitination PhosphoSitePlus
K257 Ubiquitination PhosphoSitePlus
K278 Ubiquitination PhosphoSitePlus
K292 Ubiquitination PhosphoSitePlus
S294 Phosphorylation PhosphoSitePlus
Y295 Phosphorylation PhosphoSitePlus
Y303 Phosphorylation PhosphoSitePlus
S315 Phosphorylation PhosphoSitePlus
S316 Phosphorylation PhosphoSitePlus
S317 Phosphorylation PhosphoSitePlus
S320 Phosphorylation PhosphoSitePlus   UniProt 17081983
K347 Ubiquitination PhosphoSitePlus
S381 Phosphorylation PhosphoSitePlus
K390 Ubiquitination PhosphoSitePlus
S400 Phosphorylation PhosphoSitePlus
Y433 Phosphorylation PhosphoSitePlus
S434 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T18 Phosphorylation HPRD 10644707
T184 Phosphorylation HPRD 17525332, 18212344, 18452278
T190 Phosphorylation HPRD 18452278
T194 Phosphorylation HPRD 18669648
S311 Phosphorylation HPRD 18691976, 17081983
S315 Phosphorylation HPRD 18691976, 17081983
S316 Phosphorylation HPRD 18691976, 17081983
S317 Phosphorylation HPRD 18691976, 17081983
S320 Phosphorylation HPRD 17081983
T324 Phosphorylation HPRD 17081983
Site PTM Type PTM Enzyme Score Source PMID
S4 Phosphorylation HPRD   PRO   PhosphoSitePlus 18691976, 18578522, 20068231, ...19651622
S8 Phosphorylation HPRD   PhosphoSitePlus 18578522, 20068231
T172 Phosphorylation HPRD   PhosphoSitePlus 17525332, 18212344, 18452278
T178 Phosphorylation HPRD   PhosphoSitePlus 18452278
T182 Phosphorylation HPRD   PhosphoSitePlus 18669648
S299 Phosphorylation HPRD 18691976, 17081983
S303 Phosphorylation HPRD 18691976, 17081983
S304 Phosphorylation HPRD 18691976, 17081983
S305 Phosphorylation HPRD 18691976, 17081983
S308 Phosphorylation HPRD 17081983
T312 Phosphorylation HPRD 17081983


Q9Y6E0 (STK24) as PTM Enzyme



Substrate Site Score Source PMID
Q15208 (STK38) T444 neXtProt   Signor 16314523, 21262772
Q8TAE6 (PPP1R14C) T73 PhosphoSitePlus 25531779
Q9Y2H1 (STK38L) T442 neXtProt   PhosphoSitePlus   Signor 16314523
Q9Y6E0 (STK24) T190 neXtProt   PhosphoSitePlus   Signor   UniProt 17046825, 17657516, 23186163


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000036617 (hSTK24/iso:2/Phos:1) pS4 PRO 18691976


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K38 T38 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ]
K44 E44 Biomuta DOID:3070 / malignant glioma [ tcga ]
S46 F46 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
T182 K182 Biomuta DOID:1793 / pancreatic cancer [ icgc, tcga ] DOID:10283 / prostate cancer [ cosmic ]
T190 A190 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
K292 N292 Biomuta DOID:363 / uterine cancer [ tcga ]
S311 R311 Biomuta DOID:3571 / liver cancer [ icgc ]
S317 F317 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
K347 N347 Biomuta DOID:363 / uterine cancer [ tcga ]
K390 R390 Biomuta DOID:263 / kidney cancer [ cosmic ]
S434 F434 Biomuta DOID:263 / kidney cancer [ cosmic ]