iPTMnet Report for Q9Y6E0 (STK24)
Protein Information
| UniProt AC / UniProt ID | Q9Y6E0 / STK24_HUMAN |
| Protein Name | Serine/threonine-protein kinase 24 |
| Gene Name | Name: STK24 Synonyms:MST3,STK3; |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:Q9Y6E0 |
| PRO Name | serine/threonine-protein kinase 24 (human) |
| Definition | A serine/threonine-protein kinase 24 that is encoded in the genome of human. |
| Short Label | hSTK24 |
| Category | organism-gene |
DAG ViewQ9Y6E0 (STK24) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| D2 | Acetylation | score1 | UniProt | 19369195, 21406692, 20068231 | ||
| R4 | Phosphorylation | score1 | UniProt | 18691976, 21406692, 20068231, ... | ||
| T18 | Phosphorylation | P17612 (PRKACA) | score3 | neXtProt phospho.ELM PhosphoSitePlus Signor UniProt | 10644707 | |
| K38 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K44 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S46 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K52 | Ubiquitination | score1 | PhosphoSitePlus | |||
| C89 | Methylation | score1 | IEDB | 31844290 | ||
| Y93 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K142 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K151 | Ubiquitination | score1 | PhosphoSitePlus | |||
| T182 | Phosphorylation | score3 | PhosphoSitePlus RLIMS-P | 22229648 | ||
| T184 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K187 | Ubiquitination | score1 | PhosphoSitePlus | |||
| T190 | Phosphorylation | Q9Y6E0 (STK24) | score4 | neXtProt PhosphoSitePlus Signor UniProt | 23186163, 17046825, 20124694, ... | |
| T194 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus | 18669648 | ||
| K238 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K245 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K257 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K278 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K292 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S294 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y295 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y303 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S315 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S316 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S317 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S320 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 17081983 | ||
| K347 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S381 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K390 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S400 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y433 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S434 | Phosphorylation | score1 | PhosphoSitePlus |
|
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| T18 | Phosphorylation | score1 | HPRD | 10644707 | ||
| T184 | Phosphorylation | score0 | HPRD | 17525332, 18212344, 18452278 | ||
| T190 | Phosphorylation | score0 | HPRD | 18452278 | ||
| T194 | Phosphorylation | score0 | HPRD | 18669648 | ||
| S311 | Phosphorylation | score0 | HPRD | 18691976, 17081983 | ||
| S315 | Phosphorylation | score0 | HPRD | 18691976, 17081983 | ||
| S316 | Phosphorylation | score0 | HPRD | 18691976, 17081983 | ||
| S317 | Phosphorylation | score0 | HPRD | 18691976, 17081983 | ||
| S320 | Phosphorylation | score0 | HPRD | 17081983 | ||
| T324 | Phosphorylation | score0 | HPRD | 17081983 |
|
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| S4 | Phosphorylation | score2 | HPRD PRO PhosphoSitePlus | 18691976, 18578522, 20068231, ... | ||
| S8 | Phosphorylation | score2 | HPRD PhosphoSitePlus | 18578522, 20068231 | ||
| T172 | Phosphorylation | score2 | HPRD PhosphoSitePlus | 17525332, 18212344, 18452278 | ||
| T178 | Phosphorylation | score2 | HPRD PhosphoSitePlus | 18452278 | ||
| T182 | Phosphorylation | score2 | HPRD PhosphoSitePlus | 18669648 | ||
| S299 | Phosphorylation | score0 | HPRD | 18691976, 17081983 | ||
| S303 | Phosphorylation | score0 | HPRD | 18691976, 17081983 | ||
| S304 | Phosphorylation | score0 | HPRD | 18691976, 17081983 | ||
| S305 | Phosphorylation | score0 | HPRD | 18691976, 17081983 | ||
| S308 | Phosphorylation | score0 | HPRD | 17081983 | ||
| T312 | Phosphorylation | score0 | HPRD | 17081983 |
Q9Y6E0 (STK24) as PTM Enzyme
|
Substrate | Site | Score | Source | PMID |
|---|---|---|---|---|---|
| Q15208 (STK38) | T444 | score4 | neXtProt Signor | 16314523, 21262772 | |
| Q8TAE6 (PPP1R14C) | T73 | score2 | PhosphoSitePlus | 25531779 | |
| Q9Y2H1 (STK38L) | T442 | score3 | neXtProt PhosphoSitePlus Signor | 16314523 | |
| Q9Y6E0 (STK24) | T190 | score4 | neXtProt PhosphoSitePlus Signor UniProt | 17046825, 17657516 |
Proteoforms
| PRO ID (Short Label) | Sites | PTM Enzyme | Source | PMID | |
|---|---|---|---|---|---|
| PR:000036617 (hSTK24/iso:2/Phos:1) | pS4 | PRO | 18691976 |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| K38 | T38 | Biomuta | DOID:9256 / colorectal cancer [ cosmic, icgc ] | |
| S46 | F46 | Biomuta | DOID:4159 / skin cancer [ cosmic, icgc, tcga ] | |
| C89 | Y89 | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
| T178 | A178 | Biomuta | DOID:363 / uterine cancer [ cosmic ] | |
| T182 | K182 | Biomuta | DOID:10283 / prostate cancer [ cosmic, icgc ] | |
| T190 | A190 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] | |
| S294 | F294 | Biomuta | [ cosmic ] DOID:4159 / skin cancer [ cosmic ] | |
| S303 | L303 | Biomuta | DOID:4606 / bile duct cancer [ cosmic ] | |
| S303 | F303 | Biomuta | DOID:4159 / skin cancer [ icgc ] | |
| S305 | F305 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
| S315 | L315 | Biomuta | DOID:4606 / bile duct cancer [ cosmic ] | |
| S317 | F317 | Biomuta | DOID:4159 / skin cancer [ cosmic, icgc ] | |
| K347 | N347 | Biomuta | DOID:363 / uterine cancer [ icgc ] | |
| K390 | R390 | Biomuta | DOID:263 / kidney cancer [ cosmic ] | |
| S434 | F434 | Biomuta | DOID:263 / kidney cancer [ cosmic ] |
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