iPTMnet Report for Q9Y6D5 (ARFGEF2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9Y6D5 / BIG2_HUMAN
Protein Name Brefeldin A-inhibited guanine nucleotide-exchange protein 2
Gene Name Name: ARFGEF2
Synonyms:ARFGEP2,BIG2;
Organism Homo sapiens (Human)

PRO ID PR:Q9Y6D5
DAG View
PRO Name brefeldin A-inhibited guanine nucleotide-exchange protein 2 (human)
Definition A brefeldin A-inhibited guanine nucleotide-exchange protein 2 that is encoded in the genome of human.
Short Label hARFGEF2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9Y6D5 (ARFGEF2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 22814378
S4 O-Glycosylation GlyGen 30379171
K17 Acetylation PhosphoSitePlus
K22 Acetylation PhosphoSitePlus
K22 Ubiquitination PhosphoSitePlus
K25 Acetylation PhosphoSitePlus
K59 Ubiquitination PhosphoSitePlus
T101 Phosphorylation PhosphoSitePlus
S107 Phosphorylation PhosphoSitePlus
S214 Phosphorylation HPRD   PhosphoSitePlus   UniProt 24275569, 20068231
S218 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18691976, 21406692, 19413330, ...17081983, 19651622, 24275569, 20068231
S227 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 21406692, 23186163, ...17081983, 18691976, 19664994, 19651622, 24275569, 19690332, 20068231
S236 Phosphorylation HPRD 20068231
S240 Phosphorylation HPRD   PhosphoSitePlus 19651622
T243 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 19651622, 18669648, 17081983, ...20068231
T244 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19651622, 18691976, 23186163
S260 Phosphorylation PhosphoSitePlus
S276 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18691976, 19664995, 18452278, ...19651622, 18669648, 20068231
S277 Phosphorylation HPRD   PhosphoSitePlus   UniProt 17322306, 23186163, 18767875, ...19664994, 19007248, 18452278, 19651622, 19690332, 20068231
S279 Phosphorylation PhosphoSitePlus
T281 Phosphorylation HPRD 18691976
K302 Ubiquitination PhosphoSitePlus
S346 Phosphorylation HPRD   PhosphoSitePlus 18691976
S348 Phosphorylation HPRD   PhosphoSitePlus 18691976
S349 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18691976, 23186163
K383 Acetylation PhosphoSitePlus
T424 Phosphorylation PhosphoSitePlus
S569 Phosphorylation PhosphoSitePlus
T589 Phosphorylation PhosphoSitePlus
S590 Phosphorylation PhosphoSitePlus
S614 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18691976, 18669648
T616 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18691976, 18669648
S617 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
S620 Phosphorylation HPRD   phospho.ELM 18691976, 18669648
T621 Phosphorylation HPRD   PhosphoSitePlus 18691976
S690 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 15302935, 20068231
T691 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 15302935
S700 Phosphorylation HPRD   PhosphoSitePlus   UniProt 20068231, 24275569
C718 Methylation IEDB 31844290
K741 Ubiquitination PhosphoSitePlus
K794 Acetylation PhosphoSitePlus
Y797 Phosphorylation PhosphoSitePlus
K808 Ubiquitination PhosphoSitePlus
K840 Ubiquitination PhosphoSitePlus
T866 Phosphorylation PhosphoSitePlus
S875 Phosphorylation PhosphoSitePlus
T882 Phosphorylation PhosphoSitePlus
S883 Phosphorylation PhosphoSitePlus
T885 Phosphorylation PhosphoSitePlus
C933 Methylation IEDB 31844290
T1007 Phosphorylation PhosphoSitePlus
K1010 Ubiquitination PhosphoSitePlus
S1015 Phosphorylation PhosphoSitePlus
S1024 Phosphorylation PhosphoSitePlus
T1029 Phosphorylation PhosphoSitePlus
S1064 Phosphorylation PhosphoSitePlus
S1067 Phosphorylation PhosphoSitePlus
S1079 Phosphorylation PhosphoSitePlus
K1167 Ubiquitination PhosphoSitePlus
K1171 Ubiquitination PhosphoSitePlus
K1181 Ubiquitination PhosphoSitePlus
S1498 Phosphorylation PhosphoSitePlus
S1499 Phosphorylation PhosphoSitePlus
S1511 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19651622, 23186163, 17081983, ...18691976, 17322306, 20068231
S1513 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18691976, 18669648, 17081983, ...20068231
S1514 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18691976, 17081983, 17322306, ...18669648, 20068231
K1517 Ubiquitination PhosphoSitePlus
S1520 Phosphorylation PhosphoSitePlus
S1525 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18691976, 17525332, 23186163, ...17081983, 19651622, 19690332
S1528 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18691976, 17525332, 23186163, ...17081983, 19369195, 18767875, 19664994, 19691289, 19651622, 17322306, 19690332, 20068231
T1531 Phosphorylation PhosphoSitePlus
S1534 Phosphorylation PhosphoSitePlus
K1536 Ubiquitination PhosphoSitePlus
Y1540 Phosphorylation PhosphoSitePlus
Y1632 Phosphorylation PhosphoSitePlus
K1727 Ubiquitination PhosphoSitePlus
S1782 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18691976, 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K17 N17 Biomuta DOID:1612 / breast cancer [ cosmic ]
S218 F218 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]
T243 A243 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S260 F260 Biomuta DOID:4159 / skin cancer [ cosmic ]
S279 * Biomuta DOID:4159 / skin cancer [ cosmic ]
T281 A281 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
T281 I281 Biomuta DOID:1324 / lung cancer [ cosmic ]
S346 Y346 Biomuta DOID:1324 / lung cancer [ cosmic ]
S346 F346 Biomuta DOID:4159 / skin cancer [ cosmic ]
S569 C569 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S569 F569 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:4159 / skin cancer [ cosmic ]
T589 I589 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S590 C590 Biomuta DOID:1324 / lung cancer [ cosmic ]
S690 F690 Biomuta DOID:4159 / skin cancer [ cosmic ]
S690 Y690 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
S700 G700 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
C718 Y718 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
K741 N741 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ] DOID:1324 / lung cancer [ cosmic, icgc ]
K794 E794 Biomuta DOID:1612 / breast cancer [ cosmic ]
K794 T794 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
Y797 * Biomuta DOID:263 / kidney cancer [ cosmic ]
K840 T840 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
T882 A882 Biomuta DOID:363 / uterine cancer [ icgc ]
T882 I882 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
T1007 I1007 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1498 * Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S1511 F1511 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1513 N1513 Biomuta [ cosmic ]
S1520 C1520 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:1612 / breast cancer [ cosmic, icgc ] DOID:11934 / head and neck cancer [ icgc ]
S1534 C1534 Biomuta DOID:1324 / lung cancer [ cosmic ]
K1727 R1727 Biomuta DOID:9256 / colorectal cancer [ cosmic ]